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| 1 | Is nasopharyngeal cancer really a “Cantonese cancer”?显示文摘Nasopharyngeal cancer(NPC) is endemic in Southern China,with Guandong province and Hong Kong reporting some of the highest incidences in the world.The journal Science has called it a 'Cantonese cancer'.We propose that in fact NPC is a cancer that originated in the Bai-Yue('proto-Tai-Kadai' or 'proto-Austronesian' or 'proto-Zhuang') peoples and was transmitted to the Han Chinese in southern China through intermarriage.However,the work by John Ho raised the profile of NPC,and because of the high incidence of NPC in Hong Kong and Guangzhou,NPC became known as a Cantonese cancer.We searched historical articles,articles cited in PubMed,Google,monographs,books and Internet articles relating to genetics of the peoples with high populations of NPC.The migration history of these various peoples was extensively researched,and where possible,their genetic fingerprint identified to corroborate with historical accounts.Genetic and anthropological evidence suggest there are a lot of similarities between the Bai-Yue and the aboriginal peoples of Borneo and Northeast India;between Inuit of Greenland,Austronesian Mayalo-Polynesians of Southeast Asia and Polynesians of Oceania,suggesting some common ancestry.Genetic studies also suggest the present Cantonese,Minnans and Hakkas are probably an admixture of northern Han and southern Bai-Yue.All these populations have a high incidence of NPC.Very early contact between southern Chinese and peoples of East Africa and Arabia can also account for the intermediate incidence of NPC in these regions. | Joseph Tien Seng Wee Tam Cam Ha Susan Li Er Loong Chao-Nan Qian | 2010 | Chinese Journal of Cancer2010，29，5： | 37 |
| 2 | Associations of lifestyle and diet with the risk of nasopharyngeal carcinoma in Singapore:a case–control study显示文摘Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean population.Methods: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning practices.Results: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P < 0.001) and 2.52(95% CI 1.54–4.12; P < 0.001), respectively. Those who consumed salted vegetables at least once a week also showed a significantly increased risk of NPC than those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC. | Sook Kwin Yong Tam Cam Ha Ming Chert Richard Yeo Valerie Gaborieau James D.McKay Joseph Wee | 2017 | Chinese Journal of Cancer2017，36，2： | 12 |
| 3 | Viral genotype and hepatitis B virus DNA levels are correlated with histological liver damage in HBeAg-negative chronic hepatitis B virus infection显示文摘 | Henry Lik-Yuen Chan Steven Woon-Choi Tsang Chook-Tiew Liew Chi-Hang Tse May-Ling Wong Jessica Yuet-Ling Ching Nancy Wai-Yee Leung John Siu-Lun Tam Joseph Jao-Yiu Sung | 2002 | The American Journal of Gastroenterology2002，，2： | 1 |
| 4 | Mea- suring Overall Efficiency and Effectiveness Using DEA 显示文摘 | Mette Asmild Joseph Paradi C David Reese N Fai Tam | 2007 | European Journal of Operational Research2007，178，1： | 1 |
| 5 | Measuring overall efficiency and effectiveness using DEA 显示文摘 | Mette Asmild Joseph Paradi C David Reese N Fai Tam | 2007 | European Journal of Operational Research2007，178，1： | 1 |
| 6 | Late toxicities after conventional radiation therapy alone for nasopharyngeal carcinoma显示文摘 | Jeffrey Kit Loong Tuan Tam Cam Ha Whee Sze Ong Tian Rui Siow Ivan Weng Keong Tham Swee Peng Yap Terence Wee Kiat Tan Eu Tiong Chua Kam Weng Fong Joseph Tien Seng Wee | 2012 | Radiotherapy and Oncology2012，，3： | 1 |
| 7 | Peripheral Cannabinoid-I Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance显示文摘 | Joseph Tam Resat Cinar Jie Liu | 2012 | Cell Metab2012，16，02： | 1 |
| 8 | 新加坡的生活方式和饮食习惯与鼻咽癌风险的关系:一项病例对照研究显示文摘背景与目的鼻咽癌(nasopharyngeal carcinoma,NPC)是东南亚地区一种常见的癌症。许多研究已经对NPC的风险因素进行了研究,但一些风险因素的作用仍无定论。本研究旨在探讨新加坡人可改变的生活方式因素与NPC风险之间的关系。方法我们在新加坡进行了一项病例对照研究,在2008年至2012年期间招募了300例患者和310例对照。根据性别、种族和年龄(±5岁)对各例对照进行选择并分别与每一例患者匹配。共有290对病例和对照成功匹配。我们对多个生活方式因素,如吸烟、饮酒、各种腌制和罐头食品消费以及断奶习惯进行了研究。结果调整协变量后多因素分析显示,现行吸烟者和有既往吸烟史的参与者比从未吸烟的参与者患NPC的风险更高,优势比(odds ratios,ORs)分别为4.50 [95%置信区间(confidence interval,CI):2.58–7.86;P <0.001]和2.52(95%CI:1.54–4.12;P <0.001)。每周至少吃1次腌制蔬菜的人也比那些从不或很少食用腌制蔬菜的人表现出NPC风险显著增加,OR值为4.18(95%CI:1.69–10.38;P=0.002)。结论吸烟(现行和经常吸食)和每周1次或多次食用腌制蔬菜是NPC的生活方式风险因素,戒除这些不良因素可以降低NPC的风险。 | Sook Kwin Yong Tam Cam Ha Ming Chert Richard Yeo Valerie Gaborieau James D.McKay Joseph Wee | 2018 | 癌症2018，37，11： | 1 |
| 9 | Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection显示文摘 | Henry Lik-Yuen Chan Steven Woon-Choi Tsang Nancy Wai-Yee Leung Chi-Hang Tse Yui Hui John Siu-Lun Tam Francis Ka-Leung Chan Joseph Jao-Yiu Sung | 2002 | The American Journal of Gastroenterology2002，，5： | 1 |
| 10 | Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats显示文摘 | Julia Barsony Michaele B. Manigrasso Qin Xu Helen Tam Joseph G. Verbalis | 2013 | AGE2013，，2： | 1 |
| 11 | 脑瘤诱发的组织变化和皮层脑电图分析(英文)显示文摘健康组织和肿瘤组织具有不同的代谢,结构和热力学特性.脑瘤的代谢和结构无序性导致其有较高的熵产生.两种组织不同的熵产生决定了熵由癌流向健康组织.脑瘤和正常细胞在熵和能量方面的差异诱发皮层不同的脑电信号.研究了28个脑瘤患者的脑电图并和健康人进行比较,观察到脑瘤患者脑电图频率的降低.多数情况中慢a lpha和theta波出现在肿瘤投影区,此可能与其高熵产生和向外的熵流有关.研究认为,脑瘤的持续高熵产生和热耗散及其它物理效应使得皮层电产生慢化,从而使肿瘤及其邻近的脑组织显示出频率较低的电活性. | Járdánházy Anett Járdánházy Tamás LUO Liao-fu Molnár Joseph | 2007 | 内蒙古大学学报(自然科学版)2007，38，4： | 1 |
| 12 | Effects of omega-3 supplementation on components of the endocannabinoid system and metabolic and inflammatory responses in adipose and liver of peripartum dairy cows显示文摘Background:Dietary supplementation of omega-3 fatty acids can reduce the activation of the endocannabinoid system(ECS)by decreasing the availability of arachidonic acid,thus lowering endocannabinoids(e CBs)levels.The ECS is a modulator of energy metabolism,stress response and inflammation in mammals,yet there is little information on the roles of the ECS in transition dairy cows.During the periparturient period,the adipose tissue and liver are the main metabolic organs that participate in the adaptations of dairy cows to onset of lactation;however,exceeded adipose tissue lipolysis and accumulation of lipids in the liver have adverse effects on cows'physiology.Here we aimed to examine whether omega-3 supplementation during the transition period will modulate ECS activation and affect metabolic and inflammatory indices in postpartum dairy cows,by supplementing twenty-eight transition Holstein dairy cows with either saturated fat(CTL)or encapsulated flaxseed oil(FLX).Components of the ECS,metabolic and inflammatory markers were measured in blood,liver,and subcutaneous adipose tissue.Results:FLX supplementation reduced feed intake by 8.1%(P<0.01)and reduced plasma levels of arachidonic acid(by 44.2%;P=0.02)and anandamide(by 49.7%;P=0.03)postpartum compared to CTL.The m RNA transcription levels of the cannabinoid receptor 1(CNR1/CB1)tended to be lower(2.5 folds)in white blood cells of FLX than in CTL(P=0.10),and protein abundance of ECS enzyme monoacylglycerol lipase was higher in peripheral blood mononuclear cells of FLX than in CTL(P=0.04).In adipose tissue,palmitoylethanolamide levels were lower in FLX than in CTL(by 61.5%;P=0.02),relative m RNA transcription of lipogenic genes were higher,and the protein abundance of cannabinoid receptor 2(P=0.08)and monoacylglycerol lipase(P=0.10)tended to be higher in FLX compared to CTL.Hepatic 2-arachidonoylglycerol tended to be higher(by 73.1%;P=0.07),and interlukin-6 m RNA transcription level was 1.5 folds lower in liver of FLX than in CTL(P=0.03).Conclusions:Nutritional supplementation of omega-3 fatty acids seems to partly modulate ECS activation,which could be related to lower feed intake.The altered ECS components in blood,adipose tissue and liver are associated with moderate modulations in lipid metabolism in the adipose and inflammation in liver of peripartum dairy cows. | Gitit Kra Jayasimha Rayalu Daddam Uzi Moallem Hadar Kamer Radka Kočvarova Alina Nemirovski GAndres Contreras Joseph Tam Maya Zachut | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 13 | High incidence of nasopharyngeal cancer: similarity for 60% of mitochondrial DNA signatures between the Bidayuhs of Borneo and the Bai-yue of Southern China显示文摘Populations in Southern China (Bai-yue) and Borneo (Bidayuh) with high incidence of nasopharyngeal cancer (NPC) share similar mitochondrial DNA signatures, supporting the hypothesis that these two populations may share the same genetic predisposition for NPC, which may have first appeared in a common ancestral reference population before the sea levels rose after the last ice age. | Joseph Wee Tam Cam Ha Susan Loong Chao-Nan Qian | 2012 | Chinese Journal of Cancer2012，31，9： | 0 |
| 14 | 摄影作品欣赏显示文摘 | | 2018 | 复印报刊资料(当代文萃)2018，0，5： | 0 |
| 15 | A proposed modulatory role of the endocannabinoid system on adipose tissue metabolism and appetite in periparturient dairy cows显示文摘To sustain the nutrient demands of rapid fetal growth,parturition,and milk synthesis,periparturient dairy cows mobilize adipose tissue fatty acid stores through lipolysis.This process induces an inflammatory response within AT that is resolved as lactation progresses;however,excessive and protracted lipolysis compounds the risk for metabolic and inflammatory diseases.The suppression of lipolytic action and inflammation,along with amplification of adipogenesis and lipogenesis,serve as prospective therapeutic targets for improving the health of periparturient dairy cows.Generally,the activation of cannabinoid receptors by endocannabinoids enhances adipogenesis and lipogenesis,suppresses lipolysis,and increases appetite in mammals.These biological effects of activating the endocannabinoid system open the possibility of harnessing the endocannabinoid system through nutritional intervention in dairy herds as a potential tool to improve dairy cows’health,although much is still to be revealed in this context.This review summarizes the current knowledge surrounding the components of the endocannabinoid system,elaborates on the metabolic effects of its activation,and explores the potential to modulate its activity in periparturient dairy cows. | Madison N.Myers Maya Zachut Joseph Tam G.Andres Contreras | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 0 |
| 16 | Heat Transfer and Fluid Flow of Nanofluids in Laminar Radial Flow Cooling Systems显示文摘Nanofluids 被认为选择同样有趣到常规冷却剂。传统的液体限制了热转移能力,是众所周知的什么时候与普通金属相比。在传统的液体在暂停放的极其好的金属性的粒子的小数量将更加增加他们的热转移表演,因此是相当想得到的。数字调查进有在内的推迟的金属性的 nanoparticles 的冷却剂的热转移改进能力一光线, laminar 流动冷却配置被介绍。温度依赖 nanofluid 性质从在最近的文学可得到的试验性的数据被评估。结果显示可观的热转移增加与 nanoparticles 的相对小的体积部分的使用是可能的。然而,通常,这些被墙砍压力的可观的增加伴随。结果也证明与温度变量 nanofluid 性质获得的预言产出更大的热转移能力和更低的墙砍当时,强调与用经常的性质的预言相比。关键词 nanofluids - nanoparticles - 热转移 - laminar 流动 - 限制光线的流动 CLC 数字 TK | Gilles ROY Samy Joseph PALM Cong Tam NGUYEN | 2005 | Journal of Thermal Science2005，14，4： | 0 |
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