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| 1 | Role of penehyclidine in acute organophosphorus pesticide poisoning显示文摘BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone. | Shi-yuan Yu Yan-xia Gao Joseph Walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li | 2020 | World Journal of Emergency Medicine2020，11，1： | 18 |
| 2 | Venous thromboembolism in the emergency department:A survey of current best practice awareness in physicians and nurses in China显示文摘BACKGROUND: For emergency department(ED) patients, risk assessment, prophylaxis, early diagnosis and appropriate treatment of venous thromboembolism(VTE) are essential for preventing morbidity and mortality. This study aimes to investigate knowledge amongst emergency medical staff in the management of VTE. METHODS: We designed a questionnaire based on multiple scales. The questionnaire was distributed to the medical and nursing clinical staff in the large urban ED of a medical center in Northern China. Data was described with percentages and the Kruskal-Wallis test was used to compare ranked data between different groups. The statistical analysis was done using the SPSS 22.0 software.RESULTS: In this survey, 180 questionnaires were distributed and 174 valid responses(response rate of 96.67%) were collected and analyzed. In scores of VTE knowledge, no signifi cant differences were found with respect to job(doctor vs. nurse), the number of years working in clinical medicine, education level, and current position, previous hospital experience and nurses' current work location within the ED. However, in pair wise comparison, we found participants who worked in ED for more than 5 years(n=83) scored signifi cantly higher on the questionnaire than those under 5 years(n=91)(95.75 vs. 79.97, P=0.039). There was a signifi cant difference in some questions based on gender, age, job, and nurse work location, number of working years, education level, and different ED working lifetime.CONCLUSION: Our survey has shown defi ciencies among ED medical staff in knowledge and awareness of the management of VTE. We recommend several changes be considered, such as the introduction of an interdisciplinary workshop for medical staff; the introduction of a standardized VTE protocol; a mandatory study module on VTE for new physicians and nurses; the introduction of a mandatory reporting system for adverse events(including VTE). | Wen-hua Zhou Jian-qiang He Shi-gong Guo Joseph Walline Xiao-ying Liu Li-yuan Tian Hua-dong Zhu Xue-zhong Yu Yi Li | 2019 | World Journal of Emergency Medicine2019，10，1： | 8 |
| 3 | Hemodynamic characteristics in preeclampsia women during cesarean delivery after spinal anesthesia with ropivacaine显示文摘BACKGROUND Very few studies have been published on the hemodynamic changes associated with spinal anesthesia induced with ropivacaine during cesarean deliveries in preeclamptic women.AIM To record and analyze hemodynamic data in women with preeclampsia undergoing cesarean delivery after spinal anesthesia induced with ropivacaine.METHODS Ten eligible women with preeclampsia were enrolled in this prospective observational study.Spinal anesthesia was performed with 2.4 mL of 0.5%ropivacaine.Hemodynamic changes were then analyzed at multiple time points.The hemodynamic responses to vasopressor interventions and uterotonic agents,as well as maternal and neonatal outcomes were also recorded.RESULTS Stable hemodynamic trends were observed in this study.Cardiac output(CO)and stroke volume increased mildly during surgery.In contrast,mean arterial pressure and systemic vascular resistance showed a moderate decrease from induction until the end of surgery.Central venous pressure dramatically increased after delivery.Oxytocin administration was associated with the most significant hemodynamic fluctuations during surgery,namely,an increase in CO and heart rate.Phenylephrine intervention was only required in three patients,and caused an increase in mean arterial pressure and systemic vascular resistance along with a decrease in heart rate,stroke volume,and CO.No maternal and neonatal complications were observed during this study,except transient episodes of hypotension.CONCLUSION Spinal anesthesia for caesarian delivery with ropivacaine in women with preeclampsia is linked to modest hemodynamic changes of no clinical significance in this study.Careful cardiovascular monitoring is still recommended,particularly after the delivery of the fetus or the use of oxytocin. | Na Zhao Jin Xu Xiao-Guang Li Joseph Harold Walline Yi-Chong Li Lin Wang Guo-Sheng Zhao Ming-Jun Xu | 2020 | World Journal of Clinical Cases2020，8，8： | 4 |
| 4 | 系统性红斑狼疮患者急诊就诊的主诉症状显示文摘目的总结急诊就诊的系统性红斑狼疮(systemic lupus erythematosus,SLE)患者的主诉症状及特点。方法采用回顾性分析的方法对本院急诊科2009年9月至2013年1月留观的200例SLE患者主诉症状数目、常见症状分布、初治患者主诉症状分布、发热的病因等方面情况进行统计分析。结果 SLE患者急诊就诊时主诉症状以两种症状为多见(47.5%,95/200),发热是最常见症状(58%,116/200);中枢神经系统(38.5%,20/52)、呼吸系统(23.1%,12/52)和消化系统(19.2%,10/52)受累易伴发热;初治SLE患者发热病因多为狼疮活动(78.8%,26/33),非初治SLE患者发热病因多为继发感染(69.9%,58/83);感染性发热患者最常见的感染部位为肺部(81.5%,53/65)。结论急诊就诊的SLE患者主诉症状有一定的特点,了解其规律可最大程度避免误诊和漏诊。 | 韩红 于学忠 李毅 徐盛勇 须晋 Joseph Walline | 2013 | 协和医学杂志2013，4，3： | 2 |
| 5 | A survey of ventilation strategies during cardiopulmonary resuscitation显示文摘BACKGROUND:Many controversies still exist regarding ventilator parameters during cardiopulmonary resuscitation(CPR).This study aimed to investigate the CPR ventilation strategies currently being used among physicians in Chinese tertiary hospitals.METHODS:A survey was conducted among the cardiac arrest team physicians of 500 tertiary hospitals in China in August,2018.Surveyed data included physician and hospital information,and preferred ventilation strategy during CPR.RESULTS:A total of 438(88%)hospitals completed the survey,including hospitals from all 31 Chinese mainland provinces.About 41.1%of respondents chose delayed or no ventilation during CPR,with delayed ventilations all starting within 12 minutes.Of all the respondents who provided ventilation,83.0%chose to strictly follow the 30:2 strategy,while 17.0%chose ventilations concurrently with uninterrupted compressions.Only 38.3%respondents chose to intubate after initiating CPR,while 61.7%chose to intubate immediately when resuscitation began.During bagvalve-mask ventilation,only 51.4%of respondents delivered a frequency of 10 breaths per minute.In terms of ventilator settings,the majority of respondents chose volume control(VC)mode(75.2%),tidal volume of 6–7 mL/kg(72.1%),PEEP of 0–5 cmH2O(69.9%),and an FiO2 of 100%(66.9%).However,62.0%of respondents had mistriggers after setting the ventilator,and 51.8%had high pressure alarms.CONCLUSION:There is a great amount of variability in CPR ventilation strategies among cardiac arrest team physicians in Chinese tertiary hospitals.Guidelines are needed with specific recommendations on ventilation during CPR. | Ye-cheng Liu Yan-meng Qi Hui Zhang Joseph Walline Hua-dong Zhu | 2019 | World Journal of Emergency Medicine2019，10，4： | 2 |
| 6 | Tension hydropneumothorax in a Boerhaave syndrome patient:A case report显示文摘Dear editor,Boerhaave syndrome,firstly described by Hermann Boerhaave in 1724,is a rare and life-threatening condition characterized by spontaneous transmural tear of the oesophagus.[1]The early diagnosis of Boerhaave syndrome is extremely important since a delay in the diagnosis can increase the mortality rate.[2]Here,we reported a Boerhaave syndrome patient combined with tension hydropneumothorax. | Chun-ting Wang Hui Jiang Joseph Walline Yan Li Jian Wang Jun Xu Hua-dong Zhu | 2021 | World Journal of Emergency Medicine2021，12，3： | 1 |
| 7 | Is rosuvastatin protective against sepsis-associated encephalopathy? A secondary analysis of the SAILS trial显示文摘BACKGROUND:Sepsis is a common cause of death in emergency departments and sepsis-associated encephalopathy(SAE)is a major complication.Rosuvastatin may play a neuroprotective role due to its protective effects on the vascular endothelium and its anti-inflammatory functions.Our study aimed to explore the potential protective function of rosuvastatin against SAE.METHODS:Sepsis patients without any neurological dysfunction on admission were prospectively enrolled in the“Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome”study(SAILS trial,ClinicalTrials.gov number:NCT00979121).Patients were divided into rosuvastatin and placebo groups.This is a secondary analysis of the SAILS dataset.Baseline characteristics,therapy outcomes,and adverse drug events were compared between groups.RESULTS:A total of 86 patients were eligible for our study.Of these patients,51 were treated with rosuvastatin.There were significantly fewer cases of SAE in the rosuvastatin group than in the placebo group(32.1%vs.57.1%,P=0.028).However,creatine kinase levels were significantly higher in the rosuvastatin group than in the placebo group(233[22-689]U/L vs.79[12-206]U/L,P=0.034).CONCLUSION:Rosuvastatin appears to have a protective role against SAE but may result in a higher incidence of adverse events. | Shi-yuan Yu Zeng-zheng Ge Jun Xiang Yan-xia Gao Xin Lu Joseph Harold Walline Mu-bing Qin Hua-dong Zhu Yi Li | 2022 | World Journal of Emergency Medicine2022，13，5： | 1 |
| 8 | The Current State of Corneal Reshaping显示文摘 | Jeffrey J. Walline Brien A. Holden Mark A. Bullimore Marjorie J. Rah Penny A. Asbell Joseph T. Barr Patrick J. Caroline H Dwight Cavanagh Nick Despotidis Fonn Desmond Bruce H. Koffler Kevin Reeder Helen A. Swarbrick Lisa G. Wohl | 2005 | Eye & Contact Lens: Science & Clinical Practice2005，，5： | 1 |
| 9 | Do corticosteroids have a role in treating Ebola virus disease?显示文摘Dear Editor,Humans have been fighting Ebola virus disease(EVD)since its first outbreak in 1976 in Yambuku village in the Democratic Republic of the Congo(previously Zaire).EVD is part of the Filoviridae family of viruses that includes Ebola and Marburg viruses.To date,EVD,one of the most deadly communicable diseases known to humans,has had15 outbreaks in Africa.In 2014,the most severe and complicated outbreak yet swept through the West African countries of Guinea,Liberia,Nigeria,Senegal and Sierra Leone, | XU Jun TAN DingYu FU YangYang WALLINE Joseph YU XueZhong | 2015 | Science China(Life Sciences)2015，58，1： | 1 |
| 10 | What does H7N9 mean and how can we be prepared for the next flu pandemic?显示文摘In early 2013,the novel H7N9 influenza virus was identified as a human-infecting virus in China.The virus causes pneumonia,respiratory failure,acute respiratory distress syndrome,multi-organ failure and death[1].As of 27 May2013,130 known cases of H7N9 infection were confirmed for China's Mainland.Of these cases,36 resulted in death,while 57 patients have recovered according to the Chinese National Health and Family Planning Commission.At the commencement of the H7N9 outbreak,health care providers worldwide,especially those in front-line clinical areas such as emergency rooms and outpatient clinics,began to | XU Jun YU XueZhong WALLINE Joseph | 2013 | Science China(Life Sciences)2013，56，11： | 1 |
| 11 | Treatment of hyperkalemic emergencies显示文摘Hyperkalemic emergency(HE)refers to life-threatening hyperkalemia consisting of a high serum potassium level with severe complications(e.g.,dysrhythmias,cardiac arrest,or myopathy).^([1])Hyperkalemic emergencies(HEs)are commonly encountered(2%–3%)in the emergency department(ED).^([2,3]) | Yao Wu Yang-yang Fu Hua-dong Zhu Jun Xu Joseph Harold Walline | 2022 | World Journal of Emergency Medicine2022，13，3： | 0 |
| 12 | 糖皮质激素在埃博拉病毒病治疗中可能的作用及应用前景显示文摘埃博拉病毒病(Ebola virus disease,EVD),过去称为埃博拉出血热,是一种由埃博拉病毒(Ebola virus,EBOV)引起的严重的、高病死率的流行性出血热.1976年,EVD第一次出现在中部非洲的扎依尔(现为刚果民主共和国)和南苏丹.此后的40多年里,非洲发生不同规模的埃博拉疫情共24次,导致1590人死亡,总体病死率高达66.61%. | 谈定玉 徐军 付阳阳 Joseph Walline 于学忠 | 2015 | 中国科学:生命科学2015，45，1： | 0 |
| 13 | Morbidity and mortality risk factors in emergency department patients with Acinetobacter baumannii bacteremia显示文摘BACKGROUND:Acinetobacter baumannii(AB)bacteremia is an increasingly common and often fatal nosocomial infection.Identification of morbidity and mortality risk factors for AB bacteremia in emergency department(ED)patients may provide ways to improve the clinical outcomes of these patients.METHODS:The records for 51 patients with AB bacteremia and 51 patients without AB infection were collected and matched in a retrospective case-control study between 2013 and 2015 in a singlecenter ED.Risk factors were analyzed by Chi-square and multivariate logistic regression statistical models.RESULTS:A significant risk factor for morbidity was the presence of a central venous catheter(CVC)(P<0.001).The mortality rate for the 51 patients with AB bacteremia was 68.6%.Risk factors for mortality were the presence of a CVC(P=0.021)and an ED stay longer than two weeks(P=0.015).CONCLUSION:AB infections lead to high morbidity and mortality.The presence of a CVC was associated with higher morbidity and mortality in patients with AB bacteremia.Avoiding CVC insertions may improve outcomes in ED patients with AB bacteremia. | Rui-xue Sun Priscilla Song Joseph Walline He Wang Ying-chun Xu Hua-dong Zhu Xue-zhong Yu Jun Xu | 2020 | World Journal of Emergency Medicine2020，11，3： | 0 |
| 14 | Adenovirus sneak attacks during the H7N9 flu season显示文摘The H7N9 influenza virus made headlines recently, with outbreaks in Chinese urban centers. These infections continue a recent trend of novel virus outbreaks, such as those involving SARS coronavirus and the H1N1 influenza virus. These outbreaks have been likened to tropical storms, and like prior ’viral storms’ the latest H7N9 influenza virus | XU Jun LI Chen WALLINE Joseph YU XueZhong | 2013 | Science China(Life Sciences)2013，56，9： | 0 |
| 15 | My mother is looking blue显示文摘Dear editor,A 76-year-old Chinese female presented by ambulance to the Emergency Department complaining of dizziness,headache and fatigue.Her son claimed that the patient“turned blue”three hours prior to onset of the patient’s symptoms.Paramedics noted the patient’s SpO2 was 83%on room air with no improvement with a nonrebreather mask.Past medical history was signifi cant for diabetes and hypertension.Family,social and medication history were non-contributory. | Howard Tat Chun Chan Anselm Wang Hei Hui Colin Graham Joseph Walline | 2019 | World Journal of Emergency Medicine2019，10，4： | 0 |
| 16 | A novel predictor of unsustained return of spontaneous circulation in cardiac arrest patients through a combination of capnography and pulse oximetry: a multicenter observational study显示文摘BACKGROUND:Unsustained return of spontaneous circulation(ROSC)is a critical barrier to survival in cardiac arrest patients.This study examined whether end-tidal carbon dioxide(ETCO_(2))and pulse oximetry photoplethysmogram(POP)parameters can be used to identify unsustained ROSC.METHODS:We conducted a multicenter observational prospective cohort study of consecutive patients with cardiac arrest from 2013 to 2014.Patients’general information,ETCO_(2),and POP parameters were collected and statistically analyzed.RESULTS:The included 105 ROSC episodes(from 80 cardiac arrest patients)comprised 51 sustained ROSC episodes and 54 unsustained ROSC episodes.The 24-hour survival rate was significantly higher in the sustained ROSC group than in the unsustained ROSC group(29.2%vs.9.4%,P<0.05).The logistic regression analysis showed that the difference between after and before ROSC in ETCO_(2)(ΔETCO_(2))and the difference between after and before ROCS in area under the curve of POP(ΔAUCp)were independently associated with sustained ROSC(odds ratio[OR]=0.931,95%confi dence interval[95%CI]0.881-0.984,P=0.011 and OR=0.998,95%CI 0.997-0.999,P<0.001).The area under the receiver operating characteristic curve ofΔETCO_(2),ΔAUCp,and the combination of both to predict unsustained ROSC were 0.752(95%CI 0.660-0.844),0.883(95%CI 0.818-0.948),and 0.902(95%CI 0.842-0.962),respectively.CONCLUSION:Patients with unsustained ROSC have a poor prognosis.The combination ofΔETCO_(2) andΔAUCp showed signifi cant predictive value for unsustained ROSC. | Jing Yang Hanqi Tang Shihuan Shao Feng Xu Yangyang Fu Shengyong Xu Chen Li Yan Li Yang Liu Joseph Harold Walline Huadong Zhu Yuguo Chen Xuezhong Yu Jun Xu | 2024 | World Journal of Emergency Medicine2024，15，1： | 0 |
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