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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Isoflavonoids from the heartwood of Pterocarpus marsupium 显示文摘 | Mitra J Joshi T | 1983 | Phytochemistry1983，22，10： | 3 |
| 3 | A systemic granulomatous response to Schistosoma mansoni eggs alters responsiveness of bone- marrow-derived macrophages to Toll-like receptor agonists 显示文摘 | Joshi AD Raymond T Coelho AL | 2008 | J Leukoc Biol2008，83，2： | 1 |
| 4 | Present and prospective role of bioenergy in regional energy system显示文摘 | Ramachandra T V Joshi N V Subramanian D K | 2000 | Renewable Sustainable Energy Rev2000，4，4： | 1 |
| 5 | Harmonic coordinates for character articulation 显示文摘 | JOSHI P MEYER M DEROSE T et nl | 2007 | AGM Trans on Graphic2007，26，3： | 1 |
| 6 | A survey of defense mechanisms against distributed denial of service ( DDoS ) flooding attacks 显示文摘 | ZARGAR S T JOSHI J TIPPER D | 2013 | IEEE Communications Surveys & Tutorials2013，15，4： | 1 |
| 7 | Image restoration by ma-tching gradient distributions显示文摘 | Cho T S Zitnick C L Joshi N | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，4： | 1 |
| 8 | Solid state interfacial reactions of Ti3Al with Si3N4 and SiC显示文摘 | Chou T C Joshi A | 1992 | J Mater Res1992，7，： | 1 |
| 9 | Radioprotective-A pharmacological intervention for protection against ionizing radiations: A review 显示文摘 | Joshi Y Jadhav T Kadam V | 2007 | Oncol Rep2007，17，5： | 1 |
| 10 | A novel role of in-terleukin-13 receptor alpha2 in pancreatic cancer invasion andmetastasis显示文摘 | Fujisawa T Joshi B Nakajima A | 2009 | Cancer Res2009，69，： | 1 |
| 11 | Mechanical and thermal properties of poplar wood polyacrylonitrile composites 显示文摘 | Joshi T K Zaidi M G H Sah P L | 2005 | Poly- mer International2005，54，1： | 1 |
| 12 | IL-13 regulates cancer inva-sion and metastasis through IL-13Ralpha2 via ERK/AP-1pathway in mouse model of human ovarian cancer显示文摘 | Fujisawa T Joshi BH Puri RK | 2012 | Int JCancer2012，131，： | 1 |
| 13 | Influence of Ⅰ- anions on the formation and stabilization of copper nanoparticles显示文摘 | S Kapoor R Joshi T Mukherjee | 2002 | Chemical Physics Letter2002，354，： | 1 |
| 14 | Are natural fiber composites environmentally superior to glass fiber reinforced composites显示文摘 | Joshi S V Drzal L T Mohanty A K | 2004 | Composites Part A: Applied Science and Manufacturing2004，35，3： | 1 |
| 15 | Presurgical intravenous parecoxibsodium and follow-up oral vajdecoxib for pain management after laparoacop ic cholecystectomy surgery reduces op ioid requirements andop ioid-related adverse effects显示文摘 | Gan T J Joshi G P Zhao S Z | | 0，，09： | 1 |
| 16 | Catalytic epoxidation of α-pinene over bifunctional mesoporous molecular sieves 显示文摘 | On D T Kapoor M P Joshi P N | 1997 | CatalLett1997，44，34： | 1 |
| 17 | A survey of defensemechanisms against distributed denial of service ( DDoS )flooding attacks 显示文摘 | ZARGAR S T JOSHI J TIPPER D | 2013 | Communications Surveys & Tutori-als IEEE2013，15，4： | 1 |
| 18 | Analyzing social networks on the semantic web 显示文摘 | Ding L Finin T Joshi A | 2005 | IEEE Intelligent Systems2005，9，1： | 1 |
| 19 | The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokines显示文摘 | RodaJM Joshi T ButcharJP | 2007 | Clin Cancer Res2007，13，21： | 1 |
| 20 | Atrial taehycardia originating from the left coronary cusp near the aorto-mitral junction: anatomie con- siderations 显示文摘 | Shehata M Liu T Joshi N | 2010 | Heart Rhythm2010，7，： | 1 |
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