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| 1 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 2 | Helical blade versus sliding hip screw for treatment of unstable intertrochanteric hip fractures: A biomechanical evaluation显示文摘 | Eric Strauss Joshua Frank Jason Lee Frederick J. Kummer Nirmal Tejwani | 2006 | Injury2006，，10： | 3 |
| 3 | Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis显示文摘 | Tsung-Cheng Chang Erik A. Wentzel Oliver A. Kent Kalyani Ramachandran Michael Mullendore Kwang Hyuck Lee Georg Feldmann Munekazu Yamakuchi Marcella Ferlito Charles J. Lowenstein Dan E. Arking Michael A. Beer Anirban Maitra Joshua T. Mendell | 2007 | Molecular Cell2007，，： | 2 |
| 4 | A Resonant Micromachined Electrostatic Charge Sensor显示文摘 | Yong Zhu Joshua E-Y Lee Ashwin A Seshia | 2008 | IEEE Sensor Journal2008，8，9： | 1 |
| 5 | Helical blade versus sliding hip screw for treatment of unstable intertrochanteric hip fractures: A biomechanical evaluation显示文摘 | Eric Strauss Joshua Frank Jason Lee Frederick J. Kummer Nirmal Tejwani | 2006 | Injury2006，，10： | 1 |
| 6 | ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac Surgery:a report of the American college of cardiology/American heart association task force on practice guidelines (writing committee to revise the 2002 guidelines on periopera tive cardiovascular evaluation for noncardiac Surgery)显示文摘 | Lee A Fleisher Joshua A | 2007 | J Am Coll Cardiol2007，50，： | 1 |
| 7 | Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches显示文摘 | Robert Machold Shigemi Hayashi Michael Rutlin Mandar D Muzumdar Susana Nery Joshua G Corbin Amel Gritli-Linde Tammy Dellovade Jeffery A Porter Lee L Rubin Henryk Dudek Andrew P McMahon Gord Fishell | 2003 | Neuron2003，，1： | 1 |
| 8 | Delivery of Tea Polyphenols to the Oral Cavity by Green Tea Leaves and Black Tea Extract 显示文摘 | Mao - Jung Lee Joshua D Limber | 2004 | Cancer Epidemiology Biomarkers & Prevention2004，13，： | 1 |
| 9 | miR-335 and miR-363 regulation of neuroblastoma tumorigenesis and metastasis显示文摘 | Jingbo Qiao Sora Lee Pritha Paul Lauren Theiss Joshua Tiao Lan Qiao Andrew Kong Dai H. Chung | 2013 | Surgery2013，，： | 1 |
| 10 | Acute traumatic spinal epidural hematoma: imaging and neurologic outcome显示文摘 | D. Lee Bennett Michael J. George Kenjirou Ohashi Georges Y. El-Khoury Joshua J. Lucas Matthew C. Peterson | 2005 | Emergency Radiology2005，，3： | 1 |
| 11 | Delivery of Tea Polyphenols to the Oral Cavity by Green Tea Leaves and Black Tea Extract 显示文摘 | Mao-Jung Lee Joshua D Limber | 2004 | Cancer Epidemiology Biomarkers&Prevention2004，13，： | 1 |
| 12 | ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: Executive Summary显示文摘 | Lee A. Fleisher Joshua A. Beckman Kenneth A. Brown Hugh Calkins Elliott Chaikof Kirsten E. Fleischmann William K. Freeman James B. Froehlich Edward K. Kasper Judy R. Kersten Barbara Riegel John F. Robb | 2007 | Journal of the American College of Cardiology2007，，17： | 1 |
| 13 | Totally Laparoscopic Gastric Resection with Extended Lymphadenectomy for Gastric Adenocarcinoma显示文摘 | Eduardo A. Guzman Alessio Pigazzi Byrne Lee Perry A. Soriano Rebecca A. Nelson I. Benjamin Paz Vijay Trisal Joseph Kim Joshua D. I. Ellenhorn | 2009 | Annals of Surgical Oncology2009，，8： | 1 |
| 14 | Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer显示文摘 | Sergey Ivanov Shu-Yuan Liao Alla Ivanova Alla Danilkovitch-Miagkova Nadezhda Tarasova Gregor Weirich Marsha J. Merrill Martin A. Proescholdt Edward H. Oldfield Joshua Lee Jan Zavada Abdul Waheed William Sly Michael I. Lerman Eric J. Stanbridge | 2001 | The American Journal of Pathology2001，，3： | 1 |
| 15 | Management of recurrent and persistent metastatic lymph nodes in well‐differentiated thyroid cancer: A multifactorial decision‐making guide for the thyroid cancer care collaborative显示文摘 | Mark L. Urken Mira Milas Gregory W. Randolph Ralph Tufano Donald Bergman Victor Bernet Elise M. Brett James D. Brierley Rhoda Cobin Gerard Doherty Joshua Klopper Stephanie Lee Josef Machac Jeffrey I. Mechanick Lisa A. Orloff Douglas Ross Robert C. Smallri | 2015 | Head Neck2015，，4： | 1 |
| 16 | 2009 ACCF/AHA Focused Update on Perioperative Beta Blockade Incorporated Into the ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery显示文摘 | Lee A. Fleisher Joshua A. Beckman Kenneth A. Brown Hugh Calkins Elliot L. Chaikof Kirsten E. Fleischmann William K. Freeman James B. Froehlich Edward K. Kasper Judy R. Kersten Barbara Riegel John F. Robb | 2009 | Journal of the American College of Cardiology2009，，22： | 1 |
| 17 | Development of sensitive direct and indirect enzyme-linked immunosorbent assays (ELISAs) for monitoring bisphenol-A in canned foods and beverages显示文摘 | Yang Lu Joshua Peterson John Gooding Nanju Lee | 2012 | Analytical and Bioanalytical Chemistry2012，，6： | 1 |
| 18 | A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells显示文摘 | Nasun Hah Charles G. Danko Leighton Core Joshua J. Waterfall Adam Siepel John T. Lis W. Lee Kraus | 2011 | Cell2011，，4： | 1 |
| 19 | On Credibility of Simulation Studies of Telecommunication Networks显示文摘 | PAWLIKOWSKI K JOSHUA JEONG H D RUTH LEE J S | 2002 | IEEE Communications Magazine2002，，40： | 1 |
| 20 | Diagnosis and Treatment of Fetal Cardiac Disease: A Scientific Statement From the American Heart Association显示文摘 | Mary T. Donofrio Anita J. Moon-Grady Lisa K. Hornberger Joshua A. Copel Mark S. Sklansky Alfred Abuhamad Bettina F. Cuneo James C. Huhta Richard A. Jonas Anita Krishnan Stephanie Lacey Wesley Lee Erik C. Michelfelder Gwen R. Rempel Norman H. Silverman Tho | 2014 | Circulation2014，，21： | 1 |
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