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1篇 您的检索式：作者名="Joshua William Boyle"

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		题名	作者	年代	出处	被引量
	1	Aurone derivatives as Vps34 inhibitors that modulate autophagy显示文摘We report in this study the identification of a natural product-like antagonist(1a) of Vps34 as a potent autophagy modulator via structure-based virtual screening. Aurone derivative 1a strongly inhibited Vps34 activity in cell-free and cell-based assays. Significantly, 1a prevents autophagy in human cells induced either by starvation or by an mT OR inhibitor. In silico modeling and kinetic data revealed that 1a could function as an ATP-competitive inhibitor of Vps34. Moreover, it suppressed autophagy in vivo and without inducing heart or liver damage in mice. 1a could be utilized as a new motif for more selective and efficacious antagonists of Vps34 for the potential treatment of autophagy-related human diseases.	Guodong Li Joshua William Boyle Chung-Nga Ko Wu Zeng Vincent Kam Wai Wong Jian-Bo Wan Philip Wai Hong Chan Dik-Lung Ma Chung-Hang Leung	2019	Acta Pharmaceutica Sinica B2019，9，3：	1

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