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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Potentiality of Pr3+- and Pr3++Ce3+- doped crystals for tunable UV upconversion lasers 显示文摘 | Nicolas S Descroix E Joubert M F | 2003 | Opt Mater2003，22，： | 2 |
| 3 | Influence of 2-methoxyestradiol on cell mor- phology and Cdc2 Kinase activity in WHC03 esophageal carcino- ma cells显示文摘 | Joubert A Marais S | 2007 | Biomed Res2007，28，1： | 1 |
| 4 | Surface patterning of micron-sized aluminum flakes by seeded dispersion polymerization: Towards waterborne colored pigments by gold nanoparticles adsorption显示文摘 | JOUBERT M SAVE M MORNET S | 2014 | Polymer2014，55，3： | 1 |
| 5 | The effect of Alzheimer's disease and Parkinson's disease on olfaction : a meta-analysis 显示文摘 | Rahayel S Frasnelli J Joubert S | 2012 | Behav Brain Res2012，231，1： | 1 |
| 6 | Atrial natriuretic peptide-de- pendent photolabeling of a regulatory ATP-binding site on the natriuretic peptide receptor-A 显示文摘 | Joubert S Jossart C McNicoll N | 2005 | FEBS J2005，272，21： | 1 |
| 7 | Job demands,job resources,burnout and work engagement of managers at a platinum mine in the North West Province显示文摘 | S ROTHMANN JOUBERT J H M | 2007 | South African Journal Of Business Management2007，38，3： | 1 |
| 8 | 显示文摘 | Ram S Joubert J C | 1992 | Appl Phys Lett1992，61，5： | 1 |
| 9 | CCR3 expression and function in asthmatic airway smooth muscle cells显示文摘 | Joubert P Lajoie-Kadoch S Labonte I | | 0，，： | 1 |
| 10 | The effect of Alzheimer's disease and Parkinson's disease on olfactory: A meta-analysis显示文摘 | Rahayel S Frasnelli J Joubert S | 2012 | Behavioural Brain Research2012，231，： | 1 |
| 11 | Identification bymass spectrometry of two-dimensional gel electrophoresis-separated proteins extracted from lager brewing yeast显示文摘 | Joubert R Strub J M Zugmeyer S | 2001 | Electrophoresis2001，22，14： | 1 |
| 12 | CCR3 expression and function in asthmatic airway smooth muscle cells 显示文摘 | Joubert P Lajoie-Kadoch S Laborite I | 2005 | J Immunol2005，175，4： | 1 |
| 13 | TNF-α and IFN-γ inversely modulate expression of the IL-17E receptor in airway smooth muscle cells显示文摘 | Lajoie-Kadoch S Joubert P Letuve S | 2006 | J Physiol Lung Cell Mol Physio2006，1290，： | 1 |
| 14 | Impaired configurational processing in a case of progressive prosopagnosia associated with predominant right temporal lobe atrophy显示文摘 | Joubert S Felician O Barbeau E | 2003 | Brain2003，126，： | 1 |
| 15 | CCR3 expression and function in asthmatic airwary smooth muscle cells显示文摘 | Joubert P Lajoie-Kadoch S Labonte I | 2005 | Immunol2005，175，4： | 1 |
| 16 | Preteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4显示文摘 | Gagnon D Joubert S Sénéchal H | 2009 | J Virol2009，83，9： | 1 |
| 17 | Proteasomal deg- radation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4显示文摘 | Gagnon D Joubert S S6n6chal H | 2009 | J Virol2009，83，9： | 1 |
| 18 | Potentiality of Pr3+-and Pr3+ +Ce3+-doped crystals for tunable UV upconversion lasers显示文摘 | Nicolas S Descroix E Joubert M F | | 0，，： | 1 |
| 19 | Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4 显示文摘 | GAGNON D JOUBERT S SENECHAL H | 2009 | J Virol2009，83，9： | 1 |
| 20 | Literature review on mango weevil:Stemochetus mangiferae (Fabricius) (Coleoptera:Curculionidae)显示文摘 | GrovéT Joubert P H M S de Beer | | 0，，： | 1 |
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