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| 1 | The mini player with diverse functions:extracellular vesicles in cell biology,disease,and therapeutics显示文摘Extracellular vesicles(EVs)are tiny biological nanovesicles ranging from approximately 30–1000 nm in diameter that are released into the extracellular matrix of most cell types and in biofluids.The classification of EVs includes exosomes,microvesicles,and apoptotic bodies,dependent on various factors such as size,markers,and biogenesis pathways.The transition of EV relevance from that of being assumed as a trash bag to be a key player in critical physiological and pathological conditions has been revolutionary in many ways.EVs have been recently revealed to play a crucial role in stem cell biology and cancer progression via intercellular communication,contributing to organ development and the progression of cancer.This review focuses on the significant research progress made so far in the role of the crosstalk between EVs and stem cells and their niche,and cellular communication among different germ layers in developmental biology.In addition,it discusses the role of EVs in cancer progression and their application as therapeutic agents or drug delivery vehicles.All such discoveries have been facilitated by tremendous technological advancements in EV-associated research,especially the microfluidics systems.Their pros and cons in the context of characterization of EVs are also extensively discussed in this review.This review also deliberates the role of EVs in normal cell processes and disease conditions,and their application as a diagnostic and therapeutic tool.Finally,we propose future perspectives for EV-related research in stem cell and cancer biology. | Abhimanyu Thakur Xiaoshan Ke Ya-Wen Chen Pedram Motallebnejad Kui Zhang Qizhou Lian Huanhuan Joyce Chen | 2022 | Protein & Cell2022，13，9： | 3 |
| 2 | Incorporating the patient perspective: a critical review of clinical practice guidelines for im- plantable cardioverter defibrillator therapy 显示文摘 | Joyce KE Lord S Matloek DD | 2013 | J Interv Card Elec- trophysiol2013，36，2： | 1 |
| 3 | Incorporating the patient perspective: a critical review of clinical practice guidelines for implantable cardioverter defibrillator therapy显示文摘 | Joyce KE Lord S Matlock DD | 2013 | J Interv Card Electr ophysiol2013，36，2： | 1 |
| 4 | Risk factors for pediatric invasive pneumococcal disease in the Intermountain West, 1996-2002 显示文摘 | Haddad MB Porucznik CA Joyce KE | 2008 | Ann Epidemiol2008，18，2： | 1 |
| 5 | LY320135,a novel cannabinoid CB1 receptor antagonist,unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation显示文摘 | Felder CC Joyce KE Briley EM | 1998 | J Pharmacol Exp Ther1998，284，1： | 1 |
| 6 | LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation 显示文摘 | Felder CC Joyce KE Briley EM | 1998 | Pharmacol Exp Ther1998，284，1： | 1 |
| 7 | Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus 显示文摘 | Liao HX Lynch R Zhou T Gao F Alam SM Boyd SD Fire AZ Roskin KM Schramm CA Zhang Z ZhuJ Sha- piro L NISC Comparative Sequencing Program Mullikin JC Gnanakaran S Hraber P Wiehe K Kelsoe G Yang G Xia SM Montefiori DC Parks R Lloyd KE Scearce RM Soderberg KA Cohen M Kamanga G Louder MK Tran LM Chen Y Cai F Chen S Moquin S Du X Joyce MG Srivatsan S Zhang B Zheng A Shaw GM Hahn BH Kepler TB Korber BT Kwong PD Mascola JR Haynes BF | 2013 | Nature2013，496，7446： | 1 |
| 8 | False positive head-up tilt:显示文摘 | Fabio M Leonelli Ke Wang Joyce M Evans Abhijit R Patwardhan Michael G Ziegler Andrea Natale Charles S Kim Kathleen Rajikovich Charles F Knapp | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 9 | Incorporating the patient erspective:a critical review of clinical practice guidelines for im-plantable cardioverter defibrillator therapy显示文摘 | Joyce KE Lord S Matlock DD | 2013 | J Interv Card Elec-trophysiol2013，36，2： | 1 |
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