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| 1 | 奶牛业中霉菌和霉菌毒素的问题(一)显示文摘霉菌毒素是由真菌(霉菌)产生的毒性次级代谢产物,当动物采食了被污染的饲料,或者接触或吸人霉菌时,可引起不良影响(霉菌中毒),其生物学影响包括肝和肾的中毒、中枢神经系统与雌激素的影响等。只有部分霉菌产生霉菌毒素,称为产毒霉菌。霉菌毒素的化学变化多,这也代表化学家族的多样性——分子量范围约200~500。 | 王银东 L W Whitlow W M Hagler Jr | 2010 | 中国畜牧杂志2010，46，2： | 5 |
| 2 | The endoscopic assessment of esophagitis: A progress report on observer agreement显示文摘 | D Armstrong JR Bennett AL Blum J Dent FT De Dombal JP Galmiche L Lundell M Margulies JE Richter SJ Spechler GN Tytgat L Wallin | 1996 | Gastroenterology1996，，1： | 2 |
| 3 | Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer显示文摘 | Timothy L Cover Richard M Peek Jr | 2013 | Gut Microbes2013，，： | 2 |
| 4 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 5 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 6 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 7 | Serum levels of follicl-stimulating hormone during the bovine estrous cycle 显示文摘 | Akbar A M Reichert L E Jr Dunn T G Jr | 1974 | J Anim Sci1974，39，： | 1 |
| 8 | Effect of fermented soya beans on diarrhoea and feed efficiency in weaned piglets显示文摘 | Kiers J L Meijer J C Nout M JR | 2003 | Journal of App lied Microbiology2003，95，3： | 1 |
| 9 | Comparing seeded organic-fiber mat with direct soil seeding for warm-season turf grass establishment显示文摘 | Hensler K L Baldwin B S Goatley J M Jr | 2001 | Hort Technology2001，11，2： | 1 |
| 10 | Resistance to cusp fracture in endodonticallytreated teeth 显示文摘 | Wendt S L Jr Harris B M Hunt T E | 1987 | Dent Mater1987，3，5： | 1 |
| 11 | Correlation between the surface chemistry of annealed IF steel and the growth of a galvanneal coating显示文摘 | Feliu S Jr Perez-Revenga M L | 2005 | Acta Materilia2005，53，9： | 1 |
| 12 | Time-domain modeling, characterization,and measurements of anechoic and semi-anechoic electromagnetic test chambers显示文摘 | Holloway C L McKenna P M Dalke R A Perala R A and Devor C L Jr | 2002 | Electromagnetic Compatibility IEEE Transactions on2002，44，： | 1 |
| 13 | Etiology of prurit- '显示文摘 | Resneck JS Jr Van Beek M Furmanski L | 2004 | JAMA2004，292，21： | 1 |
| 14 | A simple reversed phase high-performance liquid chromatography method polysorbate 80 quantitation in monoclonal antibody drug products显示文摘 | ADAMO M DICK L W Jr QIU D F | 2010 | J Chromatogr B Analyt Technol Biomed Life Sci2010，878，21： | 1 |
| 15 | Wrist Ganglion Treatment: Systematic Review and Meta-Analysis显示文摘 | Head L Gencarelli JR Allen M | 2015 | J Hand Surg Am2015，40，3： | 1 |
| 16 | Optimization algorithm for fault location in transmission lines considering current trans- formers saturation显示文摘 | PEREIRA C E M Jr ZANETTA L C | 2005 | IEEE Trans on Power Delivery2005，20，2： | 1 |
| 17 | Odor control research at the Montgomery County regional composting facility显示文摘 | Hentz Jr L H Murray C M Thompson J L | 1992 | Water Environ Res1992，64，1： | 1 |
| 18 | To treat or not to treat? A meta-analysis of the use of cholinesterase inhibitors in mild cognitive impairment for delaying progression to Alzheimer's disease显示文摘 | Diniz B S Pinto J A Jr Gonzaga M L | 2009 | Eur Arch Psychiatry Clin Neurosci2009，259，： | 1 |
| 19 | The effect of buffered propionic acid-based additives alone or combined with microbial inoculation on the fermentation of high moisture corn and whole crop barley显示文摘 | Kung L Jr Myers C L Neylon J M | 2004 | Journal of Dairy Science2004，87，5： | 1 |
| 20 | Comparative uptake of plutonium from soils by Brassica juncea and Helianthus annuus 显示文摘 | LEE J H HOSSNER L R ATTREP M Jr | 2002 | Environment Pollution2002，120，2： | 1 |
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