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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | 质子泵抑制剂治疗急性反流性食管炎的系统回顾显示文摘 | Edwards SJ Tind T Lundell L 钟捷 | 2002 | 中华消化杂志2002，22，8： | 21 |
| 3 | Systematic review:Laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors显示文摘AIM:To assess laparoscopic fundoplication(LF)in partial responders to proton pump inhibitors(PPIs)for gastroesophageal reflux disease(GERD).METHODS:We systematically searched PubMed and Embase(1966-Dec 2011)for articles reporting data on LF efficacy in partial responders.Due to a lack of randomized controlled trials,observational studies were included.Of 558 articles screened,17 were eligible for inclusion.Prevalence data for individual symptoms were collated across studies according to mutually compatible time points(before and/or after LF).Where suitable,prevalence data were presented as percentage of patients reporting symptoms of any frequency or severity.RESULTS:Due to a lack of standardized reporting of symptoms,the proportion of patients experiencing symptoms was recorded across studies where possible.After LF,the proportion of partial responders with heartburn was reduced from 93.1%(5 studies)to 3.8%(5 studies),with similar results observed for regurgitation[from 78.4%(4 studies)to 1.9%(4 studies)].However,10 years after LF,35.8%(2 studies)of partial responders reported heartburn and 29.1%(1 study)reported regurgitation.The proportion using acidsuppressive medication also increased,from 8.8%(4studies)in the year after LF to 18.2%(2 studies)at 10years.In the only study comparing partial responders to PPI therapy with complete responders,higher symptom scores and more frequent acid-suppressive medication use were seen in partial responders after LF.CONCLUSION:GERD symptoms improve after LF,but subsequently recur,and acid-suppressive medication use increases.LF may be less effective in partial responders than in complete responders. | Lars Lundell Martin Bell Magnus Ruth | 2014 | World Journal of Gastroenterology2014，20，3： | 10 |
| 4 | Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus显示文摘AIM To determine the impact of upwards titration of proton pump inhibition(PPI) on acid reflux, symptom scores and histology, compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE) patients were studied. In group 1(n = 24), increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization. At each assessment, ambulatory 24 h p H recording, endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire, GERD/HRLQ) were performed. Group 2(n = 30) consisted of patients with a previous fundoplication. RESULTS In group 1, acid reflux normalized in 23 of 24 patients, resulting in improved GERD/HRQL scores(P = 0.001), which were most pronounced after the starting dose of PPI(P < 0.001). PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P = 0.5). Normalization of acid reflux in both groups was associated with reduction in papillary length, basal cell layer thickness, intercellular space dilatation, and acute and chronic inflammation of squamous epithelium. CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients, especially after the first dose of PPI, reaching the same level as after a successful fundoplication. Minor changes were found among GERD markers at the morphological level. | Francisco Baldaque-Silva Michael Vieth Mumen Debel Bengt Hakanson Anders Thorell Nuno Lunet Huan Song Miguel Mascarenhas-Saraiva Gisela Pereira Lars Lundell Hanns-Ulrich Marschall | 2017 | World Journal of Gastroenterology2017，23，17： | 3 |
| 5 | The Development and Validation of an Endoscopic Grading System for Barrett’s Esophagus: The Prague C & M Criteria显示文摘 | Prateek Sharma John Dent David Armstrong Jacques J.G.H.M. Bergman Liebwin Gossner Yoshio Hoshihara Janusz A. Jankowski Ola Junghard Lars Lundell Guido N.J. Tytgat Michael Vieth | 2006 | Gastroenterology2006，，5： | 3 |
| 6 | The endoscopic assessment of esophagitis: A progress report on observer agreement显示文摘 | D Armstrong JR Bennett AL Blum J Dent FT De Dombal JP Galmiche L Lundell M Margulies JE Richter SJ Spechler GN Tytgat L Wallin | 1996 | Gastroenterology1996，，1： | 2 |
| 7 | Extent of lymphadenectomy has no impact on postoperative complications after gastric cancer surgery in Sweden显示文摘Objective: Curative gastric cancer surgery entails removal of the primary tumor with adequate margins including regional lymph nodes. European randomized controlled trials with recruitment in the 1990's reported increased morbidity and mortality for D2 compared to D1. Here, we examined the extent of lymphadenectomy during gastric cancer surgery and the associated risk for postoperative complications and mortality using the strengths of a population-based study.Methods: A prospective nationwide study conducted within the National Register of Esophageal and Gastric Cancer. All patients in Sweden from 2006 to 2013 who underwent gastric cancer resections with curative intent were included. Patients were categorized into D0, D1, or D1+/D2, and analyzed regarding postoperative morbidity and mortality using multivariable logistic regression.Results: In total, 349(31.7%) patients had a D0, 494(44.9%) D1, and 258(23.4%) D1+/D2 lymphadenectomy.The 30-d postoperative complication rates were 25.5%, 25.1% and 32.2%(D0, D1 and D1+/D2, respectively), and 90-d mortality rates were 8.3%, 4.3% and 5.8%. After adjustment for confounders, in multivariable analysis, there were no significant differences in risk for postoperative complications between the lymphadenectomy groups. For90-d mortality, there was a lower risk for D1 vs. D0.Conclusions: The majority of gastric cancer resections in Sweden have included only a limited lymphadenectomy(D0 and D1). More extensive lymphadenectomy(D1+/D2) seemed to have no impact on postoperative morbidity or mortality. | chih-han kung huan song weimin ye magnus nilsson jan johansson ioannis rouvelas tomoyuki irino lars lundell jon a tsai mats lindblad | 2017 | Chinese Journal of Cancer Research2017，29，4： | 2 |
| 8 | Chicken neuropeptide yfamily receptor Y4:a receptor with equal affinity for pancreatic polypeptide, neuropeptide Y and peptide Y Y显示文摘 | Lundell I Boswell T Larhammar D | 2002 | J Mol Endoerinol2002，28，： | 1 |
| 9 | The effect of antireflux operation on lower oesophageal sphincter tone and postprandial symptoms显示文摘 | Lundell L Myer JC Jamieson G | 1993 | Scand J Gastroenterol1993，28，6： | 1 |
| 10 | Theoretical study of decomposition pathway for HArF and HKrF显示文摘 | CHABAN G M LUNDELL J GERBER R B | 2002 | J Chem Phys Lett2002，364，： | 1 |
| 11 | WHIPS Volvo's whiplash protection study显示文摘 | JAKOBSSON L LUNDELL B NORIN H | 2000 | Accid Analysis Prev2000，21，： | 1 |
| 12 | Pancreas-sparing Duodenectomy : Technique and Indications 显示文摘 | Lundell L Hyltander A Liedman B | 2002 | Eur J Surg2002，168，2： | 1 |
| 13 | Does earlyadministration of thyroxine reduce the development of Graves' oph- thalmopathy after radioiodine treatment? 显示文摘 | TALLSTEDT L LUNDELL G BLOMGREN H | 1994 | Eur J Endocrinol1994，130，5： | 1 |
| 14 | Advances in the treatment of patients with gastric adenoeareinoma 显示文摘 | Foukakis T Lundell L GubanskiM | 2007 | Acta Oncol2007，46，3： | 1 |
| 15 | Upper gastrointestinal hemorrhage - surgical aspects 显示文摘 | Lundell L | 2003 | Dig Dis2003，21，1： | 1 |
| 16 | The effect of prophylactic transpapillary pancreatic stent insertion on clinically significant leak rate following distal pancreatectomy:results of a prospective controlled clinical trial显示文摘 | Frozanpor F Lundell L Segersvard R | | 0，，06： | 1 |
| 17 | Posttraumatic stress among woman after induced abortion:a Swedish multi-centre cohort study显示文摘 | Inger Wallin Lundell Susanne Georgss Ohman Orjan Frans | 2013 | BMC Women''s Health2013，13，52： | 1 |
| 18 | Etiology and risk factors for esophageal carcinoma显示文摘 | Lundell L R | 2010 | Dig Dis2010，28，45： | 1 |
| 19 | Aspiration biopsy cytology in diagnosis of thyroid cancer 显示文摘 | Lowhagen T Willems JS Lundell G Sundblad R Granberg PO | 1981 | World J Surg1981，5，1： | 1 |
| 20 | Systematic review of proton pump inhibitors for the acute treatment of reflux exophagitis显示文摘 | Edwards SJ Lind T Lundell L | 2001 | Aliment pharmacol ther2001，15，11： | 1 |
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