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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 3 | Rapid recovery protocol for pefi - operative care of total hip and total hip knee arthroplasty patients 显示文摘 | BEREND K R LOMBARDI A V Jr MALLOPY T H | 2004 | Surg technol Int2004，13，： | 1 |
| 4 | Siliclatic sequence stratigraphy in well logs,cores,and outcrops:concepts for high-resolution correlation of time and facies 显示文摘 | Wagoner J C V Mitchun R M Compion K M Jr | 1990 | AAPG1990，74，9： | 1 |
| 5 | Constructed wetlands for livestock wastewater management显示文摘 | Knight R L Payne Jr V W E Borer R E | 2000 | Ecological Engineering2000，15，： | 1 |
| 6 | Leksell Gamma Knife lesioning of the rat hippocampus: the relationship between radiation dose and functional and structural damage显示文摘 | Liscak R Vladyka V Novotny J Jr | 2002 | J Neurosurg2002，97，5： | 1 |
| 7 | A closed-loop logistics model for remanufacturing显示文摘 | JANYARAMAN V GUIDER V Jr SRIVASTAVA R | 1999 | Journal of the Operational Research Society1999，50，5： | 1 |
| 8 | A closed loop logistics model for remanufacturing显示文摘 | Jayaraman V Guide V D R Jr Sricastava R | 1999 | Journal of Operational Research Society1999，，50： | 1 |
| 9 | Thermal stability, of LiPF6 salt and Li-ion battery electrolytes eontaining LiPF6 显示文摘 | YANG H ZHUANG G V JR P N R | 2006 | J Power Sources2006，161，1： | 1 |
| 10 | A novel function for apolipoprotein B:lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice显示文摘 | Farese R V Jr Cases S Ruland S L | 1996 | J Lipid Res1996，37，2： | 1 |
| 11 | Fast pattern matching in strings 显示文摘 | KNUTH D E MORRIS JR J H PRATT V R | 1977 | SIAM Journal on Computing1977，6，2： | 1 |
| 12 | Electrochemical studies on LaNi5-xSnx metal hydride alloys显示文摘 | Ratnakumar B V Witham C Bowman R C Jr Hightower A Fultz B | | 0，，： | 1 |
| 13 | Information loss over time defines the memory defect of propofol:a comparative response with thiopental and dexmedetomidine显示文摘 | Veselis R A Reinsel R A Feshchenko V A Johnson R Jr | 2004 | Anesthesiology2004，101，4： | 1 |
| 14 | Purification,properties and regulation of glutamic dehydrogenase of Bacillus licheniformis显示文摘 | PHIBBS P V Jr BERNLOHR R W | 1971 | Journal of Bacteriology1971，106，2： | 1 |
| 15 | Production of high solids acrylic coating resin with t - amyl peroxides: a new way to meet VOC requirements 显示文摘 | V R Kamath J D Sargent Jr | 1987 | Journal of Coatings Technology1987，59，746： | 1 |
| 16 | Seizure outcome after surgery for epilepsy due to focal cortical dysplastie lesions 显示文摘 | Alexandre V Jr Walz R Bianchin M M | 2006 | Seizure2006，15，6： | 1 |
| 17 | Radiation tol- erance of functioning pituitary tissue in gamma knife sur- gery for pituitary adenomas显示文摘 | Vladyka V Liscdk R Novotny J Jr | 2003 | Neurosurgery2003，52，2： | 1 |
| 18 | The role of warm-up in muscular injury prevention显示文摘 | SAFRAN M R GARRETT W E Jr SEABER A V | 1988 | Am J Sports Med1988，16，： | 1 |
| 19 | A closed-loop lo- gistics model for remanufacturing显示文摘 | Jayaraman V Guide Jr V Srivastava R | 1999 | Journal of the Opera- tional Research Society1999，50，5： | 1 |
| 20 | Production planning and control for remanufacturing: Industry practice and research needs显示文摘 | Daniel V R Guide Jr | 2000 | J of Operations Management2000，18，4： | 1 |
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