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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 3 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 4 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 5 | Molecular cloning, expression and phylogenetic analyses of parvalbumin in tilapia, Oreochromis mossambicus显示文摘 | Lee S J Ju C C Chu S L | 2007 | J Exp Zool2007，307，1： | 1 |
| 6 | Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum显示文摘 | Gomez B Jr Ardakani S Ju J | 1995 | Clin Chem1995，4111，： | 1 |
| 7 | Metallurgical analyses of fracture characteristics in weldHeat-affected Zones of cryogenic steel (Ⅰ)-Evaluation of local brittle zone phenomena using synthetic CGHAZ Specimens 显示文摘 | JANG J JU J-B | 2000 | Journal of Korean Institute of Metal and Materials2000，，7： | 1 |
| 8 | Characterization of UV-cured polyester acrylate films containing acrylate functional polydimethylsiloxane显示文摘 | Kim H K Ju H T Hong J W | 2003 | European Polymer Journal2003，39，11： | 1 |
| 9 | Two flaps andZ-plasty technique for correction of longitudinal era lobe cleft显示文摘 | JU H S RHIE J W | 2005 | Br J Plast Surg2005，58，4： | 1 |
| 10 | Effective Elastic Moduli of Two-Phase Composites Containing Randomly Dispersed Spherical Inhomogeneities显示文摘 | Chen T M | 1994 | Acta Mechanica1994，103，： | 1 |
| 11 | Enhanced sensor capability of juxtaposed fi-eyclodextrin rings in TiO2 ultrathin matrix as determined by cyclic surface-polarization impedance measurement 显示文摘 | Yang DH Ju M J Maeda A | 2008 | Sensors and Materials2008，20，4： | 1 |
| 12 | Thermomechanical cracking due to moving frictional loads显示文摘 | HUANG J H JU F D | 1985 | Wear1985，102，12： | 1 |
| 13 | Prediction methodol- ogy for ground vibration induced by passing trains on bridge structures 显示文摘 | Chen Y J Ju S H Ni S H | 2007 | Journal of Sound and Vibration2007，302，45： | 1 |
| 14 | Gel chromatography of oligosaccharides up to 60 显示文摘 | MIC HAEL J JU RGEN S | 1982 | J Chromatogr1982，247，： | 1 |
| 15 | On energy-based coupled elastoplastic damage theories:constitutive modeling and computational aspects显示文摘 | JU J W | 1989 | International Journal of Solids Structures1989，25，7： | 1 |
| 16 | Impurity bound polaron in a magnetic field in quantum-well structure显示文摘 | Liu Z X Shi J J Ju G X | 1997 | Superlattices Microstruct1997，22，3： | 1 |
| 17 | Skeletal muscle respiratory uncoupling prevents diet induced obesity and insulin resistance in mice显示文摘 | Li B Nolte L A Ju J S | 2000 | Nat Med2000，6，： | 1 |
| 18 | 显示文摘 | Ding S J Ju C P Lin J H C | 2000 | Journal of Materials Science:Materials in Medicine2000，11，1： | 1 |
| 19 | Flavonoids as superoxide scavengers and antioxidants显示文摘 | CHEN Y T ZHENG R L JIA Z J JU Y | 1990 | Free Radical Biology and Medicine1990，9，1： | 1 |
| 20 | Gaussian Mixture Discriminant Analysis and Sub-pixel Land Cover Characterization in Remote Sensing 显示文摘 | JU J C KOLACZYK E D GOPAL S | 2003 | Remote Sensing Environment2003，84，： | 1 |
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