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| 1 | Constraint-induced movement therapy in treatment of acute and sub-acute stroke: a meta-analysis of 16 randomized controlled trials显示文摘OBJECTIVE: The aim of this meta-analysis was to evaluate the clinical efficacy of constraint-induced movement therapy in acute and sub-acute stroke.DATA SOURCES: The key words were stroke, cerebrovascular accident, constraint-induced therapy, forced use, and randomized controlled trial. The databases, including China National Knowledge Infrastructure, Wan Fang, Weipu Information Resources System, Chinese Biomedical Literature Database, Pub Med, Medline, Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews, were searched for studies on randomized controlled trials for treating acute or sub-acute stroke published before March 2016. DATA SELECTION: We retrieved relevant randomized controlled trials that compared constraint-induced movement therapy in treatment of acute or sub-acute stroke with traditional rehabilitation therapy(traditional occupational therapy). Patients were older than 18 years, had disease courses less than 6 months, and were evaluated with at least one upper extremity function scale. Study quality was evaluated, and data that met the criteria were extracted. Stata 11.0 software was used for the meta-analysis. OUTCOME MEASURES: Fugl-Meyer motor assessment of the arm, the action research-arm test, a motor activity log for amount of use and quality of movement, the Wolf motor function test, and a modified Barthel index.RESULTS: A total of 16 prospective randomized controlled trials(379 patients in the constraint-induced movement-therapy group and 359 in the control group) met inclusion criteria. Analysis showed significant mean differences in favor of constraint-induced movement therapy for the Fugl–Meyer motor assessment of the arm(weighted mean difference(WMD) = 10.822; 95% confidence intervals(95% CI): 7.419–14.226), the action research-arm test(WMD = 10.718; 95% CI: 5.704–15.733), the motor activity log for amount of use and quality of movement(WMD = 0.812; 95% CI: 0.331–1.293) and the modified Barthel index(WMD = 10.706; 95% CI: 4.417–16.966). CONCLUSION: Constraint-induced movement therapy may be more beneficial than traditional rehabilitation therapy for improving upper limb function after acute or sub-acute stroke. | Xi-hua Liu Juan Huai Jie Gao Yang Zhang Shou-wei Yue | 2017 | Neural Regeneration Research2017，12，9： | 9 |
| 2 | Investigation on the applicability of turbulent- Prandtl-number models for liquid lead-bismuth euteetie 显示文摘 | CHEN Fei HUAI Xiulan CAI Juan | 2013 | Nuclear Engineering and Design2013，257，： | 1 |
| 3 | Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS显示文摘The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering technique.This imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum transfers.To satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 atm.It uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 m2.The detector works in air,which is separated from the vacuum environment to facilitate installation and maintenance.The characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental measurements.The results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam experiment.The detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event rate.Observations of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully. | Lin Zhu Jian‑Rong Zhou Yuan‑Guang Xia Liang Xiao Hong Luo Xiao‑Juan Zhou Wen‑Qin Yang Bei‑Ju Guan Xing‑Fen Jiang Yan‑Feng Wang Hong Xu Hai‑Yun Teng Li‑Xin Zeng Jia‑Jie Li Lei Hu Ke Zhou Yong‑Xiang Qiu Pei‑Xun Shen Jun Xu Li‑Jiang Liao Xiao‑Zhuang Wang Gui‑An Yang Huai‑Chan Chen Ju‑Ping Xu Zhi‑Duo Li Song‑Lin Wang Jian Zhuang Yu‑Bin Zhao Jun‑Rong Zhang Wen Yin Zhi‑Jia Sun Yuan‑Bo Chen | 2023 | Nuclear Science and Techniques2023，34，1： | 0 |
| 4 | Influence of terminal alkyl chain length on helical twisting property of chiral 1,2-propanediol derivatives显示文摘在这研究,有不同终端烷基链长度的 chiral 1,2-propanediol 衍生物的一个新奇系列被英尺红外综合并且描绘, 1 H NMR 和 DSC。在做了进一位 nematic 液体水晶主人以后,所有 chiral 掺杂物导致了与温度变化展出螺旋倒置的 chiral nematic 液体晶体。结果显示那终端烷基链长度在 chiral 掺杂物的螺旋状的扭动的性质上有突出的影响。与增加终端烷基链长度,分子的扭动力量增加,螺旋倒置温度当阶段转变温度减少时,稍微变化。odd–甚至效果可以在 chiral 掺杂物的分子的扭动力量存在。 | Wei Huang Guang Da Yang Zhen Yu Bian Xiao Juan Wu Guo Jing Ma Qi Huang Huai Yang | 2009 | Chinese Chemical Letters2009，20，12： | 0 |
| 5 | Increased gene and protein expressions of the transient receptor potential vanilloid receptor 4 following sustained pure mechanical pressure on rat dorsal root ganglion neurons显示文摘Dorsal root ganglion(DRG) neurons from newborn Wistar rats cultured in vitro were pressurized with 20,40,80 or 120 mm Hg compressive loadings(1 mm Hg = 0.133 kPa) for 12,24,48 or 72 hours,respectively.The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide test showed that pressures less than 80 mm Hg had no obvious impact on the activity of DRG neurons.The protein expression levels of transient receptor potential vanilloid receptor 4(TRPV4),transient receptor potential vanilloid receptor 1,transient receptor potential channel of melastatin type 8,and transient receptor potential subtype ankyrin 1 were assessed by western blot analysis.The mRNA expression of TRPV4 was assessed by real-time PCR.The results showed that sustained mechanical compression up-regulated TRPV4 mRNA and protein expression in the rat DRG neurons,in a time-dependent fashion.Similar changes were not found in the protein expression of transient receptor potential vanilloid receptor 1,transient receptor potential channel of melastatin type 8,and transient receptor potential subtype ankyrin 1.Images of cells using a laser scanning confocal microscope showed that the sustained mechanical pressure increased the number of responsive DRG neurons and was synergistic on the enhanced Ca2+ responses to the TRPV4 phorbol ester agonist 4α-phorbol 12,13-didecanoate and hypotonic solutions.These findings demonstrate that sustained mechanical compressive loading in vitro increases the expression of TRPV4 mRNA and protein in DRG neurons and sensitizes TRPV4 Ca2+ signals.Mechanical compression does not impact other ion channels in the transient receptor potential family. | Yang Zhang Juan Huai Yonghui Wang Yanqin Wang Shouwei Yue | 2011 | Neural Regeneration Research2011，6，35： | 0 |
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