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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese显示文摘 | Judith Aron-Wisnewsky Caroline Minville Joan Tordjman Patrick Lévy Jean-Luc Bouillot Arnaud Basdevant Pierre Bedossa Karine Clément Jean-Louis Pépin | 2011 | Journal of Hepatology2011，，1： | 2 |
| 3 | Characterization and photo- Fenton treatment of used tires leachate 显示文摘 | Judith S Tomas L Ormad P | 2006 | Journal of Hazardous Materials2006，136，1： | 1 |
| 4 | Mir451 regulates zebrafish erythroid maturation in vivo via its target gata2显示文摘 | LUKE P JUDITH E L WIGARD P K | 2009 | Blood2009，113，： | 1 |
| 5 | A comparison of in situ hybridisation, reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ-RT-PCR for the detection of canine distemper virus RNA in Paget’s disease显示文摘 | Judith A Hoyland Janet A Dixon Jacqueline L Berry Michael Davies Peter L Selby Andrew P Mee | 2003 | Journal of Virological Methods2003，，2： | 1 |
| 6 | The analysis of cell images显示文摘 | JUDITH M S P MENDELSOHN M L | 1966 | Annals of the New York Academy of Sciences1966，128，1： | 1 |
| 7 | Characterization and photo-Fenton treatment of used tires leaehate显示文摘 | I Judith S Tomas L Ormad P | 2006 | Journal of Hazanlous Materials2006，136，87： | 1 |
| 8 | DNA probe for identification of larvae of the commercial surfclam (Spisula solidissima)显示文摘 | Janice L Bel Judith P Grassle A | 1998 | Mol Mar Biol Biotechnol1998，7，2： | 1 |
| 9 | The Magnetization of γ Fe4N: Theory vs Experiment 显示文摘 | Eitel L P B Judith D Niels E C | 2009 | Phys Status Solidi B2009，246，5： | 1 |
| 10 | Receptor and ligands implicated in hunman T cell costimulatory process显示文摘 | JUDITH L KATHARINA G P PETER S | | 0，，02： | 1 |
| 11 | Structural bases of hydrogen tunneling in enzymes: progress and puzzles 显示文摘 | Zhao X L Judith P K | 2004 | Curr Opin Struct Biol2004，14，6： | 1 |
| 12 | Arctic ground squirrel neuronal progenitor cells resist oxygen and glucose deprivation-induced death显示文摘AIM: To investigate the influence of ischemia/reperfusion on arctic ground squirrel(AGS) neuronal progenitor cells(NPCs), we subjected these cultured cells to oxygen and glucose deprivation.METHODS: AGS NPCs were expanded and differentiated into NPCs and as an ischemia vulnerable control, commercially available human NPCs(hNPCs) were seeded from thawed NPCs. NPCs, identified by expression of TUJ1 were seen at 14-21 d in vitro(DIV). Cultures were exposed to control conditions, hypoxia, oxygen and glucose deprivation or glucose deprivation alone or following return to normal conditions to model reperfusion. Cell viability and death were assessed from loss of ATP as well as from measures of alamarB lue~ and lactate dehydrogenase in the media and from counts of TUJ1 positive cells using immunocytochemistry. Dividing cells were identified by expression of Ki67 and phenotyped by double labeling with GFAP, MAP2 ab or TUJ1. RESULTS: We report that when cultured in NeuraLife^(TM), AGS cells remain viable out to 21 DIV, continue to express TUJ1 and begin to express MAP2 ab. Viability of hN PCs assessed by fluorescence alamarB lue(arbitrary units) depends on both glucose and oxygen availability [viability of hNPCs after 24 h oxygen glucose deprivation(OGD) with return of oxygen and glucose decreased from 48151 ± 4551 in control cultures to 43481 ± 2413 after OGD, P < 0.05]. By contrast, when AGS NPCs are exposed to the same OGD with reperfusion at 14 DIV, cell viability assessed by alamar Blue increased from 165305 ± 11719 in control cultures to 196054 ± 13977 after OGD. Likewise AGS NPCs recovered ATP(92766 ± 6089 in control and 92907 ± 4290 after modeled reperfusion; arbitrary luminescence units), and doubled in the ratio of TUJ1 expressing neurons to total dividing cells(0.11 ± 0.04 in control cultures vs 0.22 ± 0.2 after modeled reperfusion, P < 0.05). Maintaining AGS NPCs for a longer time in culture lowered resistance to injury, however, did not impair proliferation of NPCs relative to other cell lineages after oxygen deprivation followed by re-oxygenation.CONCLUSION: Ischemic-like insults decrease viability and increase cell death in cultures of human NPCs. Similar conditions have less affect on cell death and promote proliferation in AGS NPCs. | Kelly L Drew Matthew Wells Rebecca McGee Austin P Ross Judith Kelleher-Andersson | 2016 | World Journal of Biological Chemistry2016，7，1： | 1 |
| 13 | Receptor and ligands implicated in hunman T cell costimulatory process显示文摘 | Judith L Katharina G P Peter S | 2010 | Immunol Lett2010，128，2： | 1 |
| 14 | Receptor and ligands implicated human T cell costimulatory process显示文摘 | Judith L Katharina G P Peter S | 2010 | Immunol Lett2010，128，2： | 1 |
| 15 | Synergy effect in the photocatalytic degradation of textile dyeing waste water by using microwave combustion synthesized zinc oxide supported activated carbon显示文摘 | SURESH P JUDITH VIJAYA J JOHN KENNEDY L | 2014 | Reaction Kinetic Mechanism and Catalysis2014，114，： | 1 |
| 16 | Two stage-two step activation process for the fabrication of micro-mesoporous carbons from rice husk显示文摘 | SURESH P JUDITH VIJAYA J JOHN KENNEDY L THINESH KUMAR R | 2013 | Journal of Bioprocess Engineering and Biorefinery2013，2，： | 1 |
| 17 | Hormone therapy: Physiological complexity belies therapeutic simplicity显示文摘 | Judith L T Donald P M Kathryn A M | 2004 | Science2004，304，5675： | 1 |
| 18 | Understanding Authority in Classrooms: A Review of Theory, Ideology and Research 显示文摘 | Judith L P Hemmings A | 2007 | Review of Educational Research2007，，4： | 1 |
| 19 | AMulti institutionalquality improvement initiative totransformEducation for chronic illness carein resident continuity practices显示文摘 | David P Judith L Bowen | 2010 | J Gen InternMed2010，25，4： | 1 |
| 20 | Validity of a verbally administered numeric rating scale to measure cancer pain intensity显示文摘 | Judith A P Cohen L F | 1997 | Cancer Nursing1997，20，2： | 1 |
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