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5篇 您的检索式：作者名="Judith Mak"

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		题名	作者	年代	出处	被引量
	1	Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease显示文摘	Peter J Barnes Maria G Belvisi Judith C.W. Mak El-Bdaoui Haddad Brian O’Connor	1995	Life Sciences1995，，11：	1
	2	Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer显示文摘	Yuan-yuan Li Sze-kwan Lam Judith Choi-wo Mak Chun-yan Zheng James Chung-man Ho	2013	Lung Cancer2013，，：	1
	3	Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries 显示文摘	Calvin K Y Chan Judith Mak Gao Yuan-sheung	2011	Am J Physiol-Heart C2011，301，6：	1
	4	Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer显示文摘	Yuan-yuan Li Sze-kwan Lam Judith Choi-wo Mak Chun-yan Zheng James Chung-man Ho	2013	Lung Cancer2013，，：	1
	5	Reducing systemic absorption and macrophages clearance of genistein by lipid-coated nanocrystals for pulmonary delivery显示文摘Pulmonary delivery is an effective drug delivery strategy for the treatment of local respiratory diseases.However,the rapid systemic absorption through the lung due to the thin barrier and persistent lung clearances influence the drug retention in the lung.In this study,we designed a lipid-coated genistein nanocrystals(Lipo-NCs)formulation to achieve enhanced efficiency of local pulmonary delivery.The LipoNCs were fabricated by modifying genistein nanocrystals(NCs)with phospholipid membrane through thin film hydration following the homogenization method.The prepared Lipo-NCs exhibited a decreased drug release rate compared with the naked NCs.Our results demonstrated that intracellular uptake and transcellular transport of NCs by the Calu-3 epithelial layer were reduced after lipid coating.Furthermore,the macrophages clearance was also impeded by this Lipo-NCs formulation.In vivo lung retention and distribution revealed that more genistein was retained in the lung after intratracheal administration of Lipo-NCs.The pharmacokinetic study displayed that the AUC((0-t))values of Lipo-NCs were 1.59-fold lesser than those of the NCs group,indicating a reduced systemic absorption.In conclusion,this research indicated that Lipo-NCs could be a suitable formulation for reducing systemic absorption and macrophages clearance,and thus enhancing drug concentration in lung by pulmonary delivery.	Yuan He Chang Liu Run Han Yingmin Liang Judith Choi Wo Mak Yinghao Zhu Haifeng Li Ying Zheng	2023	Chinese Chemical Letters2023，34，1：	0

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