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| 1 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 2 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 3 | Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery显示文摘 | Jaya Mishra Catherine Dent Ridwan Tarabishi Mark M Mitsnefes Qing Ma Caitlin Kelly Stacey M Ruff Kamyar Zahedi Mingyuan Shao Judy Bean Kiyoshi Mori Jonathan Barasch Prasad Devarajan | 2005 | The Lancet . 2005 (9466)2005，，： | 2 |
| 4 | Applying virtual reality techniques to the interactive stress analysis of a tractor lift arm 显示文摘 | Michael J Ryken Judy M Vance | 2000 | Finite Elements in Analysis and Design 352000，，： | 2 |
| 5 | Identification of an immunodominant CD4+ T cell epitope in the VP6 protein of rotavirus following intranasal immunization of BALB/C mice显示文摘 | Monica M M Mitali B Judy A B | 2007 | Virology2007，363，2： | 1 |
| 6 | Global E&P Briefs显示文摘 | Judy M | 2003 | Offshore2003，63，1： | 1 |
| 7 | Parr, 'Language-learning strategies: theory and per- ception' Jour, ELT显示文摘 | Carol Griffiths and Judy M | 2001 | 2001，，： | 1 |
| 8 | Identification of an immunodominant CD4^+ T cell epitope in the VP6 protein of rotavirus following intranasal immunization of BALB/c mice 显示文摘 | McNeal M M Basu M Judy A | 2007 | Virology2007，363，2： | 1 |
| 9 | Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs显示文摘 | Christopher R Woodman Judy M Muller M | 1997 | Am J Physiol1997，273，： | 1 |
| 10 | Postnatal depression and the quality of mother-infant interactions during the second year of life显示文摘 | Alison M Cornish Catherine McMahon Judy A Ungerer | 2008 | Australian Journal of Psychology2008，60，3： | 1 |
| 11 | Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection显示文摘 | Richard J Michelle C Judy M | 1997 | Infect Immun1997，65，5： | 1 |
| 12 | Electrostaticcomb drive of lateral polysilicon resonantors显示文摘 | Tang W C Nguyen T C H Judy M W | 1990 | Sensors and Actuators1990，，： | 1 |
| 13 | Bisphenol Ais released from used polycarbonate animal cages into water atroom temperature 显示文摘 | Howdeshell K L Peterman P H Judy B M | 2003 | Environmental Health Perspectives2003，111，9： | 1 |
| 14 | An interfaculty pain curriculum:Lessons learned from six years experience显示文摘 | Judith H Judy WW Michael M | 2008 | Pain2008，7，： | 1 |
| 15 | The Australian national workplace health project:design and baseline findings显示文摘 | Judy M Brian O Neville O | 2000 | Preventive Medicine2000，，31： | 1 |
| 16 | Thyroid incidentaloma显示文摘 | JUDY J Christopher R M | 2012 | Best Pract Res Clin Endocrinol Metab2012，26，1： | 1 |
| 17 | Ambrisentan for the management of pulmonary arterial hypertension显示文摘 | JUDY W M CHENG B S | 2008 | Clin The2008，30，5： | 1 |
| 18 | 显示文摘 | Chang C Sivertsen J M Judy J H | 1987 | IEEE Trans Magn1987，23，5： | 1 |
| 19 | Nonlinear signal-spe- cific ADC for efficient neural recording in brain-machine interfaces 显示文摘 | Judy M Sodagar A M Lotfi R | 2014 | IEEE Transactions on Biomedical Circuits and Systems2014，8，3： | 1 |
| 20 | Echocardiographic assessment of ischemic mitral regurgitation显示文摘 | David M Dudzinski and Judy Hung | 2014 | Cardiovasc Ultrasound2014，12，： | 1 |
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