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| 1 | XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks显示文摘 | Julie K Horton Mary Watson Donna F Stefanick Daniel T Shaughnessy Jack A Taylor Samuel H Wilson | 2008 | Cell Research2008，18，1： | 17 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 4 | Mediation of transforming growth factor-β1 -stimulated matrix contraction by fibroblasts 显示文摘 | Julie T Gregory S Timothy D | 2003 | Am J Pathol2003，163，： | 1 |
| 5 | Involvement of receptor activator of nuclear factor-κB ligand osteoclast differentiation factor in osteoclastogenesis from synoviocytes inrheumatoid arthritis显示文摘 | Takayanagi H Lizuka H Juli T | 2000 | Arthritis Rhem2000，43，2： | 1 |
| 6 | Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin显示文摘 | Zellweger T Miyake H July LV | 2001 | Neoplasia2001，3，4： | 1 |
| 7 | Quantifying the pH 'vital effect' in the temperate zooxanthellate coral Cladocora caespitosa: Validation of the boron seawater pH proxy显示文摘 | JULIE T PAOLO M MALCOLM M C | 2011 | Earth Planet Selett2011，303，： | 1 |
| 8 | Mouse cardiac surgery: Comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies显示文摘 | OLEG T JULIE R M MARTINA S | 2004 | Physiol Genomies2004，16，1： | 1 |
| 9 | Maintenance of genomic imprinting at the Arabidopsis medea locus requires zygotic DDM1 activity显示文摘 | JEAN-PHILIPPE VIELLE-CALZADA JULIE T CHARLES S | 1999 | Genes and Development1999，13，： | 1 |
| 10 | Photodynamic ther- apy: an innovative approach to the treatment of keloid dis- ease evaluated using subjective and objective non-invasive tools显示文摘 | SARA UD GRACE T JULIE M | 2013 | Arch Dermatol Res April2013，305，3： | 1 |
| 11 | Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy显示文摘 | July L V Akbari M Zellweger T | 2002 | Prostate2002，50，3： | 1 |
| 12 | Distribution and speciation of ambient selenium in contrasted soils, from mineral to organic rich显示文摘 | Julie Tolu Yves Thiry Ma?té Bueno Claudy Jolivet Martine Potin-Gautier Isabelle Le Hécho | 2014 | Science of the Total Environment2014，，： | 1 |
| 13 | Influence of notch severity on the iMPact fracture behavior of aluminum alloy 7055 显示文摘 | Julie Champlin J Zakrajsek T S Srivatsan | 1999 | Materials and Design1999，20，2： | 1 |
| 14 | Children's Experi- ences of Living With Juvenile Idiopathic Arthritis: A The- matic Synthesis of Qualitative Studies 显示文摘 | Allison T Julie J Jinathan C C | 2012 | Arthritis Care & Research2012，64，9： | 1 |
| 15 | Steric Stabiliza- tion of Lipid/Polymer Particle Assemblies by Poly ( ethylene gly- col) -Lipids 显示文摘 | JULIE T ANNE-LISE T LAURENT D | 2007 | Biomacromolecules2007，8，11： | 1 |
| 16 | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation显示文摘BACKGROUND Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity(CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors(TLRs), which play a central role in innate immunity.AIM To understand the mechanisms between early life event paradigm on intestinal permeability, fecal microbiota composition and CHS development in mice with TLRs expression in colonocytes.METHODS Maternal separation model(NMS) CHS model, which mimics deleterious events in childhood that can induce a wide range of chronic disorders during adulthood were used. Colonic sensitivity of NMS mice was evaluated by colorectal distension(CRD) coupled with intracolonic pressure variation(IPV) measurement. Fecal microbiota composition was analyzed by 16S rRNA sequencing from weaning to CRD periods. TLR mRNA expression was evaluated in colonocytes.Additionally, the effect of acute intrarectal instillation of the TLR5 agonist flagellin(FliC) on CHS in adult naive wildtype mice was analyzed.RESULTS Around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis, characterized by a significant decrease of species richness, an alteration of the core fecal microbiota and a specific increased relative abundance of flagellated bacteria. Only TLR5mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of FliC induced transient increase of IPV, reflecting transient CHS appearance.CONCLUSION Altogether, these data suggest a pathophysiological continuum between intestinal dysbiosis and CHS, with a role for TLR5. | Geoffroy Mallaret Amandine Lashermes Mathieu Meleine Ludivine Boudieu Julie Barbier Youssef Aissouni Agathe Gelot Benoit Chassaing Andrew T Gewirtz Denis Ardid Frederic Antonio Carvalho | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 17 | Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy显示文摘 | July LV Akbari M Zellweger T | 2002 | Prostate2002，50，3： | 1 |
| 18 | A very early rehabilitation trial for stroke (AVERT) phase II safety and feasibility显示文摘 | Julie B Helen D Amanda T Pet at al | 2008 | Stroke2008，39，： | 1 |
| 19 | Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis显示文摘 | Pierre Blanchard Anne Lee Sophie Marguet Julie Leclercq Wai Tong Ng Jun Ma Anthony T C Chan Pei-Yu Huang Ellen Benhamou Guopei Zhu Daniel T T Chua Yong Chen Hai-Qiang Mai Dora L W Kwong Shie Lee Cheah James Moon Yuk Tung Kwan-Hwa Chi George Fountzilas Li | 2015 | The Lancet Oncology2015，，： | 1 |
| 20 | Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gane clusterin显示文摘 | Zellweger T Miyake H July LV | 2001 | Neoplasia2001，3，4： | 1 |
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