|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Recovery from respiratory failure after decompression laparotomy for severe acute pancreatitis显示文摘We present three cases of patients (at the age of 56 years, 49 years and 74 years respectively) with severe acute pancreatitis (SAP), complicated by intra-abdominal compartment syndrome (ACS) and respiratory insufficiency with limitations of mechanical ventilation. The respiratory situation of the patients was significantly improved after decompression laparotomy (DL) and lung protective ventilation was re-achieved. ACS was discussed followed by a short review of the literature. Our cases show that DL may help patients with SAP to recover from severe respiratory failure. | Sylvia Siebig Igors Iesalnieks Tanja Bruennler Christine Dierkes Julia Langgartner Juergen Schoelmerich Christian E Wrede | 2008 | World Journal of Gastroenterology2008，14，35： | 7 |
| 3 | Organochlorine pesticide and heavy metal residues in some edible biota collected from Quanzhou Bay and Xinghua Bay,Southeast China显示文摘In order to assess the contamination of edible marine organisms in Quanzhou and Xinghua Bays,Fujian Province,China,concentrations of organochlorine pesticides(hexachlorocyclohexane isomers or HCHs and dichlorodiphenyltrichloroethane isomers/derivatives or DDTs) and heavy metals(Cu,Pb,Zn,As,Cr,Cd,Ni and Hg) in 13 species collected from different sites in the bays were analyzed by GC-ECD and ICP-MS.The concentration of the sum of DDTs exceeded that the sum of HCHs in the samples.Most of the organisms showed higher levels of DDTs than the first level criterion(10 ng/g) for marine biological quality in China(GB 18421-2001) but conformed to the first level criterion(20 ng/g) for HCHs.The estimated mean daily uptake of pesticides was below the level for minimal risk to the consumers.The levels of Cd,As and Pb in most organisms from both bays were markedly elevated and above the recommended legal limits for human consumption.Our results showed the need for routine monitoring of marine species contamination to ensure public and environmental health. | Mangala Yatawara Odhiambo Joshua Owago Julia E Burnet | 2010 | Journal of Environmental Sciences2010，22，2： | 7 |
| 4 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 5 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 6 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
| 7 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 8 | Axlinary thoraeotomy versus videothoraeoscopy for the treatment of primary spontaneous pneumothorax 显示文摘 | FREIXINET JL CANALIS E JULIA G | 2004 | Ann Thorac Surg2004，7，8： | 1 |
| 9 | A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis显示文摘 | Stephen H Caldwell Elizabeth E Hespenheide Jan A Redick Julia C Iezzoni Emily H Battle Bonnie L Sheppard | 2001 | The American Journal of Gastroenterology2001，，2： | 1 |
| 10 | Pre-bomb Delta 14 C variability and the Sues effect in Cariaco Basin surface waters as recorded in hermatypic corals显示文摘 | Thomas P Cole Julia E Southon John R | 2005 | Radiocarbon2005，47，： | 1 |
| 11 | Collective responsibility for learning and its effects on gains in achievement for early secondary school students显示文摘 | Julia B Smith | 1996 | American Journal of Education1996，2，104： | 1 |
| 12 | Impact of DNA extraction method on bacterial community composition measured by denaturing gradient gel electrophoresis显示文摘 | Julia R Christiane E | 2004 | Soil Biology & Biochemistry2004，36，： | 1 |
| 13 | Dietary Intake of Methionine, Cysteine, ,and Protein and Urinary Arsenic Excretion in Bangladesh 显示文摘 | Julia E Heck Jeri W | 2009 | Environ Health Perspect2009，1，1： | 1 |
| 14 | Aquatic birds as bioindicators of trophic changes and ecosystem deterioration in the Mar Menor Lagoon (SE Spain)显示文摘 | Julia M F Miguel A E S Francisco RA | 2005 | Hydrobiologia2005，550，： | 1 |
| 15 | Embryonic stem cells显示文摘 | Bishop A E Lee D K Julia M P | 2002 | J Pathol2002，197，： | 1 |
| 16 | On the numerical solution of non-linear Black-Scholes equations 显示文摘 | A JULIA E MATTHIAS | 2008 | Computers and Mathemat-ics with Applications2008，56，3： | 1 |
| 17 | Seasonal and Inter-Annual Relationships Between Vegetation and Climate in Central New Mexico, USA显示文摘 | JEREMY L W DAVIDS S G JULIA E A | 2004 | Journal of Arid Environments2004，57，4： | 1 |
| 18 | Compressive mod-ulus of ferrite containing polymer gels显示文摘 | Furukawa K Juliae E | 2002 | International Jour-nal of Modern Physics B2002，16，： | 1 |
| 19 | Bioproduction of Conjugated Linoleic Acid by ProbioticBacteria Occurs In Vitro and In Vivo in Mice 显示文摘 | JULIA B E JOHN W W HUGO D | 1996 | A-meriean Society for Nutrition J Nutr1996，，136： | 1 |
| 20 | The influence of hemorrhagic shock on propofol: a pharmacokinetic and pharmacodynamic analysis显示文摘 | Talmage E Steven K Julia W | 2003 | Anesthesiology2003，99，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员