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| 1 | Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle显示文摘Background: Exercise promotes numerous phenotypic adaptations in skeletal muscle that contribute to improved function and metabolic capacity. An emerging body of evidence suggests that skeletal muscle also releases a myriad of factors during exercise, termed 'myokines'. The purpose of this study was to examine the effects of high-intensity interval training(HIIT) on the acute regulation of the mRNA expression of several myokines, including the prototypical myokine interleukin-6(IL-6), and recently identified myokines fibronectin type III domain-containing protein 5(FNDC5)(irisin) and meteorin-like protein(METRNL).Methods: Both before and after a 20-day period of twice-daily high-volume HIIT, 9 healthy males(20.5 ± 1.5 years performed a standardized bout of high-intensity interval exercise(HIIE; 5 × 4 min at ~80% pretraining peak power output) with skeletal muscle biopsy samples(vastus lateralis) obtained at rest, immediately following exercise, and at 3 h recovery.Results: Before training, a single bout of HIIE increased IL-6(p < 0.05) and METRNL(p < 0.05) mRNA expression measured at 3 h recovery when compared to rest. Following 20 days of HIIT, IL-6 and FNDC5 mRNA were increased at 3 h recovery from the standardized HIIE bout when compared to rest(both p < 0.05). Resting METRNL and FNDC5 mRNA expression were higher following training(p < 0.05), and there was an overall increase in FNDC5 mRNA post-training(main effect of training, p < 0.05).Conclusion: In human skeletal muscle(1) an acute bout of HIIE can induce upregulation of skeletal muscle IL-6 mRNA both before and after a period of intensified HIIT;(2) Resting and overall FNDC5 mRNA expression is increased by 20 days of HIIT; and(3) METRNL mRNA expression is responsive to both acute HIIE and short-term intense HIIT. Future studies are needed to confirm these findings at the protein and secretion level in humans. | Malcolm Eaton Cesare Granata Julianne Barry Adeel Safdar David Bishop Jonathan P.Little | 2018 | Journal of Sport and Health Science2018，7，2： | 15 |
| 2 | Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury显示文摘Inducible heat shock protein 70 kD (HSP-70i) has been shown to protect cells, tissues, and organs from harmful assaults in in vivo and in vitro experimental models. Hemorrhagic shock followed by resuscitation is the principal cause of death among trauma patients and soldiers in the battlefield. Although the underlying mechanisms are still not fully understood, it has been shown that nitric oxide (NO) overproduction and inducible nitric oxide synthase (iNOS) overexpression play important roles in producing injury caused by hemorrhagic shock including increases in polymorphonuclear neutrophils (PMN) infiltration to injured tissues and leukotriene B4 (LTB4) generation. Moreover, transcription factors responsible for iNOS expression are also altered by hemorrhage and resuscitation. It has been evident that either up-regulation of HSP-70i or down-regulation of iNOS can limit tissue injury caused by ischemia/reperfusion or hemorrhage/resuscitation. In our laboratory, geldanamycin, a member of ansamycin family, has been shown to induce HSP-70i overexpression and then subsequently to inhibit iNOS expression, to reduce cellular caspase-3 activity, and to preserve cellular ATP levels. HSP-70i is found to couple to iNOS and its transcription factor. Therefore, the complex formation between HSP-70i and iNOS may be a novel mechanism for protection from hemorrhage/resuscitation-in-duced injury. | Juliann G.KIANG | 2004 | Cell Research2004，14，6： | 7 |
| 3 | 【特刊综述】睾酮和雌二醇检测方法面临的挑战和取得的进展显示文摘在患者护理、公共卫生、科学研究过程中类固醇激素的检测方法需要正确而精准,因为这些检测的标准可以保证所有的临床机构和研究机构的结果具有可比性。本文陈述了目前有关检验结果易变的主要问题以及最近美国疾病预防控制中心(CDc)针对提升检验效果所做的工作。目前,睾酮和雌二醇的检测方法还无法达到高度的正确性和精准性。虽然类固醇激素检测方法已经有了长足的进步,但是实验室内部和实验室之间的检测差异仍然未能得到相应的改善。检测标准和特异性的差异被认为是测量精度变异性的来源。最终认为,类固醇激素检测的不准确性似乎是由综合因素造成的,其中不一致的检验标准和缺乏特异性被认为是产生结果变异的两个主要因素。目前,同一批次内的化验结果也变异较大,特别是在样本浓度低的情况下。2007至2011年间的质谱分析法和CDC参考方法之间的平均绝对偏差下降了50%,由此可以看出CDC激素标准化测试程序正在提高临床化验的准确性。这种测试程序可以为CDC参考方法提供追朔源头的途径,从而减少产生测量结果变异的因素。 | Hubert W Vesper Julianne C Botelho Yuesong Wang | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 4 | Convenient synthesis of nucleoside 5'-(α-P-thio)triphosphates and phosphorothioate nucleic acids(DNA and RNA)显示文摘Modified deoxy-and ribo-nucleoside triphosphates are chemically synthesized in multiple steps due to the protection and deprotection of the nucleoside functionalities.To conveniently synthesize the S-modified triphosphates for enzymatically preparing phosphorothioate DNAs and RNAs(PS-DNA and PS-RNA) as potential therapeutics,herein we report a one-pot strategy to synthesize the deoxy-and ribo-nucleoside 5'-(α-P-thio)triphosphates(dNTPαS and NTPαS) without protecting any nucleoside functionalities.This facile synthesis is achieved by treating the nucleosides with a mild phosphitylating reagent,reacting selectively with the 5'-hydroxyl group of each unprotected nucleoside,followed by sulfurization and hydrolysis to afford the crude dNTPαS and NTPαS analogs(mixtures of Sp and Rp diastereomers).We also demonstrated that after just simple precipitation(without HPLC and ion-exchange purification),the quality of the synthesized dNTPαS and NTPαS analogs is excellent for direct DNA polymerization and RNA transcription,respectively.Since Klenow DNA polymerase and T7 RNA polymerase accept the Sp diastereomers of dNTPαS and NTPαS analogs,respectively,while the Rp diastereomers are neither substrates nor inhibitors,the diastereomerically-pure PS-DNAs and PS-RNAs can be conveniently synthesized enzymatically. | CATON-WILLIAMS Julianne FIAZ Bilal HOXHAJ Rudiona SMITH Matthew | 2012 | Science China Chemistry2012，55，1： | 3 |
| 5 | Pain management in the trauma setting显示文摘 | Mirjana L Fayez K Julianne 5 | 2005 | Semin Anesth2005，24，1： | 1 |
| 6 | An improved method for the transformation of Lactobacillus strains using electroporation显示文摘 | Ming-Qian Wei Catherine M Rush Julianne M Norman | 1995 | Journal of Microbiological Methods1995，21，1： | 1 |
| 7 | A weighted-GCV method for Lanczos-Hybrid regularization显示文摘 | Chung Julianne Nagy G J | 2008 | Electronic Transactions on Numerical Analysis2008，28，： | 1 |
| 8 | Mast cell degranulation mediates compound 48/80-induced hyperalgesia in mice显示文摘 | Devavani Chatterjea Abigail Wetzel Madison Mack Camilla Engblom Juliann Allen Carolina Mora-Solano Luisa Paredes Evelyn Balsells Tijana Martinov | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 9 | Observations on the ecology and reproduction of the sipunculan Phascolion cryptus in the Indian River Lagoon显示文摘 | MARY E RICE JULIANNE PIRANO HUGH F REICHARDT | 1983 | Florida Scientist1983，46，34： | 1 |
| 10 | Adaptive Redox Response of Mesenchymal Stromal Cells to Stimulation with Lipopolysaccharide Inflammagen: Mechanisms of Remodeling of Tissue Barriers in Sepsis显示文摘 | Nikolai V. Gorbunov Bradley R. Garrison Dennis P. McDaniel Min Zhai Pei-Jyun Liao Dilber Nurmemet Juliann G. Kiang Sumitra Miriyala | 2013 | Oxidative Medicine and Cellular Longevity2013，，： | 1 |
| 11 | Should we follow AT LSR guidelines for the management of traumaticpul monary contusion: theroleofnon-invasive ventilatory suppor 显示文摘 | Kim V Julianne K Michael P | 2002 | Resuscitatiaon2002，52，2： | 1 |
| 12 | Heat shock protein 70kDa:molecular biology,biochemistry and physiology显示文摘 | George C T | 1998 | Pharmacol Ther1998，80，2： | 1 |
| 13 | Heat shock protein 70 kDa: Molecular biology, bioche mistry and physiology 显示文摘 | JULIANN G K GEORGE C T | 1998 | Pharmaeol Ther1998，80，2： | 1 |
| 14 | Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance显示文摘 | Elizabeth R. Glaze Amy L. Lambert Adaline C. Smith John G. Page William D. Johnson David L. McCormick Alan P. Brown Barry S. Levine Joseph M. Covey Merrill J. Egorin Julie L. Eiseman Julianne L. Holleran Edward A. Sausville Joseph E. Tomaszewski | 2005 | Cancer Chemotherapy and Pharmacology2005，，6： | 1 |
| 15 | Heat shock protein 70 kDa:Molecular biology,bioche mistry and physiology 显示文摘 | JULIANN G K GEORGE C T | 1998 | Pharmacol Ther1998，80，2： | 1 |
| 16 | Open repair of pectus excavatum and carinatum deformities with minimal cartilage resection 显示文摘 | Eric W Fonkalsrud M D* Julianne Mendoza M D | 2006 | The American Journal of Surgery (S0002-9210)2006，191，6： | 1 |
| 17 | Heat shock protein 70 kDa:Molecular biology,biochemistry and physiology显示文摘 | Juliann G K George C T | 1998 | Pharmacology and Therapeutics1998，80，2： | 1 |
| 18 | Should we follow AT LSR guidelines for the management of traumaticpul monary contusion: theroleofnon-invasive ventilatory suppor 显示文摘 | Kim V Julianne K Michael P | 2002 | Resuscitatiaon2002，52，2： | 1 |
| 19 | Decomposition dynamics of aquatic macrophytes in the lower Atchafalaya, a large floodplain river显示文摘 | Juliann M. Battle Timothy B. Mihuc | 2000 | Hydrobiologia2000，，1： | 1 |
| 20 | Should we follow ATLSR guidelines for the management of traumatic pulmonary contusion:the role of non-invasive ventilatory support显示文摘 | Kim V Julianne K Michael P | 2002 | Resuscitatiaon2002，52，2： | 1 |
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