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| 1 | 光激酶C基因突变导致的大头精子畸形是阿尔及利亚男性不育症的最常见遗传因素显示文摘克氏综合征和Y染色体微缺失是过去针对男性不育症仅有的两项基因检测分析技术。北非男性经常出现两种罕见的畸形精子症:大头和圆头精子畸形,推荐进行AURKC和DPYl9L2基因检测。对阿尔及利亚男性不育患者进行以上基因检测,评估两种畸形精子症的患病率,并与克氏综合征和Y染色体微缺失的频率进行比较。我们对阿尔及利亚君士坦丁市的IbnRochd医院辅助生殖中心进行不育症咨询的599名患者进行了回顾性研究,其中404人存在精液参数异常现象。14人和7人分别患有典型的大头精子畸形或圆头精子畸形,进而对这些患者进行了AURKC和DPYl9L2基因分析显示,11名大头精子畸形患者存在4URKC基因突变(79%),相当于所有精液异常人群的2.7%。而5名圆头精子畸形患者,相当于1.2%的不育症患者,均存在DPYl9L2基因缺失。通过比较,我们预测该人群中克氏综合症和Y染色体微缺失的患病率分别是1.6%和0.23%。我们的研究表明AURKC基因突变较克氏综合症更常见,它是导致北非男性不育的主要遗传因素。此外,本文也预测了AURKC和DP"觋2基因缺陷发生率分别是Y染色体微缺失发生率的10倍和5倍。 | Leyla Ounis Abdelali Zoghmar Charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez Ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray | 2015 | Asian Journal of Andrology2015，17，1： | 5 |
| 2 | Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial显示文摘 | David Laharie Arnaud Bourreille Julien Branche Matthieu Allez Yoram Bouhnik Jerome Filippi Frank Zerbib Guillaume Savoye Maria Nachury Jacques Moreau Jean-Charles Delchier Jacques Cosnes Elena Ricart Olivier Dewit Antonio Lopez-Sanroman Jean-Louis Dupas F | 2012 | The Lancet2012，，9857： | 2 |
| 3 | Benzophenone glycosides from Gnidia involucrata显示文摘 | JULIEN F CHRISTIAN T SEVSEN S | 2000 | Phytochemistry2000，54，： | 1 |
| 4 | Optimized electrochemical performance of LiFePO4 at 60℃ with purity controlled by SQUID magnetometry 显示文摘 | ZAGHIB K RAVET N GAUTHIER M GENDRON F MAUGER A GOODENOUGH J B JULIEN C M | 2006 | Journal of Power Sources2006，163，： | 1 |
| 5 | CBI cannabinoid receptor antagonism:a new strategy for the treatment of liver fibrosis显示文摘 | Teixeira-Clerc F Julien B Grenard P | | 0，，： | 1 |
| 6 | A PSO-based global MPPT technique for distributed PV power generation显示文摘 | Hugues R Fabrizio D Julien F | 2015 | IEEE Transactions on Industrial Electronics2015，62，2： | 1 |
| 7 | Lipoprotein lipase and endothelial lipase expression in mouse brain:regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia 显示文摘 | Paradis E Clavel S Julien P Murthy MRV de Bilbao F Arsenijevic D | 2004 | Neurobiol Disease2004，15，2： | 1 |
| 8 | Antifibrogenic role of the cannabinoid receptor CB2 in the liver显示文摘 | Julien B Grenard P Teixeira-Clerc F | | 0，，3： | 1 |
| 9 | Structural, magnetic and electrochemical properties of lithium iron orthosilicate 显示文摘 | ZAGHIB K AIT SALAH A RAVET N MAUGER A GENDRON F JULIEN C M | 2006 | J Power Sources2006，160，： | 1 |
| 10 | Potential geographical distribution of alligator weed and its biological control by Agasicles hygrophila显示文摘 | Julien M H Skarratt B Maywald G F | 1995 | Journal of Aquatic Plant Management1995，33，： | 1 |
| 11 | CB2 receptors as new therapeutic targets for liver diseases显示文摘 | Lotersztajn S Teixeira-Clerc F Julien B | | 0，，2： | 1 |
| 12 | Assessing the risks of exposures to multiple chemicals with a common mechanism of toxicity: how to cumulate? 显示文摘 | Wilkinson C F Christoph G R Julien E | 2000 | Regulatory Toxicology and Pharmacology2000，31，1： | 1 |
| 13 | Neural modulation of cephalexin intestinal absorption through the di-and tripeptide brush border transporter of rat jejunum in vivo显示文摘 | Berlioz F Julien S Tsocas A | 1999 | J Pharmacol Exp Ther1999，288，： | 1 |
| 14 | Neural modulation of cephalexin intestinal absorption through the di-and tri-peptide brush transporter of rat jejunum in vivo显示文摘 | Berlioz F Julien S Tsocas A | 1999 | J Pharmacol Exp Ther1999，288，3： | 1 |
| 15 | CB1 cannabinoid receptor antagonism:a new strategy for the treatment of liver fibrosis显示文摘 | Teixeira-Clerc F Julien B Grenard P | 2006 | Nat Med2006，12，6： | 1 |
| 16 | Two-dimen sional simulations of extreme floods on a large watershed显示文摘 | ENGLAND J F VELLEUX M L JULIEN P Y | 2007 | Journal of Hydrology2007，347，： | 1 |
| 17 | Direct Evidence of Cementite Dissolution in Drawn Pearlitic Steels Observed by Tomographic Atom Probe显示文摘 | Danoix F Julien D Sauvage X | | 0，，01： | 1 |
| 18 | TREX:Spa- tially distributed model to assess watershed contaminant transport and fate 显示文摘 | VELLEUX M L ENGLAND J F JULIEN P Y | 2008 | Science of the Total Environment2008，404，： | 1 |
| 19 | Hepatic fibrosis: molecular mechanisms and drug targets 显示文摘 | Lotersztajn S Julien B Teixeira-Clerc F | 2005 | Annu Rev Pharmacol2005，45，： | 1 |
| 20 | Lactate and veno-arterial carbon dioxide difference/arterial -venous oxygen difference ratio, but not central venous oxygen saturation, predict Increase in oxygen consumption in fluid responders显示文摘 | Monnet X Julien F Ait-Hamou N | 2013 | Crit Care Med2013，41，6： | 1 |
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