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| 1 | A Regulatory Module Controlling CA-Mediated Endosperm Cell Expansion Is Critical for Seed Germination in Arabidopsis显示文摘A key component of seed germination is the interplay of mechanical forces governing embryo growth and the surrounding restraining endosperm tissue.Endosperm cell separation is therefore thought to play a critical role in the control of this developmental transition.Here we demonstrate that in Arabidopsis thaliana seeds,endosperm cell expansion is a key component of germination.Endosperm cells expand to accommodate embryo growth prior to germination.We show that this is an actively regulated process supported by spatiotemporal control of the cell expansion gene EXPANSIN 2 (EXPA2).The NAC transcription factors NAC25 and NACIL were identified as upstream regulators of EXPA2 expression,gibbereliinmediated endosperm expansion,and seed germination.The DELLA protein RGL2 repressed activation of the EXPA2 promoter by NAC25/NACIL.Taken together,our findings uncover a key role of the GA/ DELLA-NAC25/NACIL-EXPA2 network in regulating endosperm cell expansion to control the seed-toseedling transition. | Rocio Sanchez-Montesino Laura Bouza-Morcillo Julietta Marquez Melania Ghita Salva Duran-Nebreda Luis Gomez Michael J.Holdsworth George Bassel Luis Onate-Sanchez | 2019 | Molecular Plant2019，12，1： | 11 |
| 2 | Modification of titanium surface via Ag-,Sr-and Si-containing micro-arc calcium phosphate coating显示文摘The current research is devoted to the study of the modification of the titanium implants by the micro-arc oxidation with bioactive calcium phosphate coatings containing Ag or Sr and Si elements.The coatings’microstructure,phase composition,morphology,physicochemical and biological properties were examined by scanning electron microscopy(SEM),transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy(EDX)and X-ray diffraction(XRD).Ag-containing and Sr-Si-incorporated coatings were formed in alkaline and acid electrolytes,respectively.The formation of the coatings occurred at different ranges of the applied voltages,which led to the significant difference in the coatings properties.The trace elements Ag,Sr and Si participated intensively in the plasma-chemical reactions of the micro-arc coatings formation.Ag-containing coatings demonstrated strong antibacterial effect against Staphylococcus aureus AТСС6538-P.MTT in vitro test with 3T3-L1 fibroblasts showed no cytotoxicity appearance on Sr-Si-incorporated coatings. | Mariya B.Sedelnikova Ekaterina G.Komarova Yurii P.Sharkeev Anna V.Ugodchikova Tatiana V.Tolkacheva Julietta V.Rau Evgeny E.Buyko Vladimir V.Ivanov Vladimir V.Sheikin | 2019 | Bioactive Materials2019，4，1： | 6 |
| 3 | Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy显示文摘Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure rate.To address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on titanium.Coatings morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is shown.Antimicrobial efficacy is investigated against four Gram positive and Gram negative bacterial strains and against C.albicans fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of silver.Then,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also tested.Results indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical properties.Biological studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell adhesion.No cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of silver.Instead,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when silver-substituted.These findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications. | Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi Marco Fosca Enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola Baldini Julietta V.Rau | 2021 | Bioactive Materials2021，6，8： | 2 |
| 4 | Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests显示文摘 | Richard F A Logan Julietta Patnick Claire Nickerson Lynn Coleman Matt D Rutter Christian von Wagner | 2012 | Gut2012，，10： | 2 |
| 5 | On brain activity mapping: Insights and lessons from Brain Decoding Project to map memory patterns in the hippocampus显示文摘The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research. | TSIEN Joe Z. LI Meng OSAN Remus CHEN GuiFen LIN LongNian WANG Phillip Lei FREY Sabine FREY Julietta ZHU DaJiang LIU TianMing ZHAO Fang KUANG Hui | 2013 | Science China(Life Sciences)2013，56，9： | 1 |
| 6 | Open-label study of ultra low-dose mifepristone for the treatment of uterine leiomyomata显示文摘 | Steve H.Eisinger Julietta Fiscella Thomas Bonfiglio | | 0，，： | 1 |
| 7 | A review on current research status of the surface modification of Zn-based biodegradable metals显示文摘Recently,zinc and its alloys have been proposed as promising candidates for biodegradable metals(BMs),owning to their preferable corrosion behavior and acceptable biocompatibility in cardiovascular,bone and gastrointestinal environments,together with Mg-based and Fe-based BMs.However,there is the desire for surface treatment for Zn-based BMs to better control their biodegradation behavior.Firstly,the implantation of some Zn-based BMs in cardiovascular environment exhibited intimal activation with mild inflammation.Secondly,for orthopedic applications,the biodegradation rates of Zn-based BMs are relatively slow,resulting in a long-term retention after fulfilling their mission.Meanwhile,excessive Zn2+release during degradation will cause in vitro cytotoxicity and in vivo delayed osseointegration.In this review,we firstly summarized the current surface modification methods of Zn-based alloys for the industrial applications.Then we comprehensively summarized the recent progress of biomedical bulk Zn-based BMs as well as the corresponding surface modification strategies.Last but not least,the future perspectives towards the design of surface bio-functionalized coatings on Zn-based BMs for orthopedic and cardiovascular applications were also briefly proposed. | Wei Yuan Dandan Xia Shuilin Wu Yufeng Zheng Zhenpeng Guan Julietta V.Rau | 2022 | Bioactive Materials2022，7，1： | 1 |
| 8 | Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests显示文摘 | Richard F A Logan Julietta Patnick Claire Nickerson Lynn Coleman Matt D Rutter Christian von Wagner | 2012 | Gut2012，，10： | 1 |
| 9 | In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration显示文摘New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous tissues.Taking inspiration from basic composition of the mammalian bones,composed of collagen,apatite and a number of substitution ions,among them magnesium(Mg2+),in this work,novel composite scaffolds composed of collagen(10%)-hydroxyapatite(HAp)(90%)and collagen(10%)-HAp(80%)-Mg(10%)were developed.The lyophilization was used for composites preparation.An insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive X-Ray.The HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen fibrils.The samples were tested for degradation in Simulated Body Fluid(SBF)solution by soaking for up to 28 days.The release of Mg from collagen(10%)-HAp(80%)-Mg(10%)composite during the period of up to 21 days was attested,this composite being characterized by a decreased degradation rate with respect to the composite without Mg.The developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration. | Iulian V.Antoniac Aurora Antoniac Eugeniu Vasile Camelia Tecu Marco Fosca Viktoriya G.Yankova Julietta V.Rau | 2021 | Bioactive Materials2021，6，10： | 1 |
| 10 | Risk factors for adverse events related to polypectomy in the English Bowel Cancer Screening Programme显示文摘 | Matthew Rutter Claire Nickerson Colin Rees Julietta Patnick Roger Blanks | 2014 | Endoscopy2014，，02： | 1 |
| 11 | High glucosinolate broccoli:a delivery system for sulforaphane显示文摘 | Golge Sarikamis Julietta Marquez | 2006 | Mol Breeding2006，18，： | 1 |
| 12 | 癌症一级预防的环境与职业干预:一个跨部门的政策框架显示文摘[背景]每年,全球新发癌症近1300万例,癌症死亡760万例;63%的癌症死亡病例发生在中、低收入国家。有相当比例的癌症是由环境和工作场所中致癌物暴露所致。[目的]为环境和职业性癌症的一级预防制定基于循证的全球愿景和战略。[方法]通过在PubMed中组合使用'环境的'、'职业的'、'暴露'、'癌症'、'一级预防'和'干预'这些搜索词,确定相关研究。为补充文献综述,于2011年3月17—18日在西班牙阿斯图里斯亚召开了'癌症的环境与职业决定因素:一级预防干预'国际会议,该会议由世界卫生组织主办。[讨论]很多由环境和职业引起的癌症都是可以预防的。一级预防政策通过减少或消除非自愿暴露于确认或潜在致癌物质,可最有效地实现预防目的。根据现有的知识,这些策略直接且经济有效,还具有附带效益,即通过减少共同风险因素的暴露,协同降低其他非传染性疾病的风险。[结论]通过整合环境和职业性致癌物初级干预来重振全球癌症控制政策是可能的。 | Carolina Espina Miquel Porta Joachim Schüz Ildefonso Hernández Aguado Robert V.Percival Carlos Dora Terry Slevin Julietta Rodriguez Guzman Tim Meredith Philip J.Landrigan Maria Neira 汪源 何蓉 金泰廙 | 2013 | 环境与职业医学2013，30，10： | 0 |
| 13 | Exploring challenges ahead of nanotechnology for biomedicine显示文摘This special issue is dedicated to the selected papers of the 1st biennial International Conference BioMaH-BioMaterials for Healthcare“Biomaterials for Tissue and Genetic Engineering and the Role of Nanotechnology”held in Rome(Italy)in October 17-20,2016.The special issue is focused on the new frontiers of bioactive materials facing challenges and embracing opportunities in the field of tissue regeneration and repair.The focus includes a wide range of chemical,physical,and biological aspects,with the scope of exploring emerging technologies for a large variety of engineered materials,their combinations,and interfaces with specific biofunctionality. | Julietta V.Rau Roberto De Santis Gianni Ciofani | 2017 | Bioactive Materials2017，2，3： | 0 |
| 14 | Factors influencing the drug release from calcium phosphate cements显示文摘Thanks to their biocompatibility,biodegradability,injectability and self-setting properties,calcium phosphate cements(CPCs)have been the most economical and effective biomaterials of choice for use as bone void fillers.They have also been extensively used as drug delivery carriers owing to their ability to provide for a steady release of various organic molecules aiding the regeneration of defective bone,including primarily antibiotics and growth factors.This review provides a systematic compilation of studies that reported on the controlled release of drugs from CPCs in the last 25 years.The chemical,compositional and microstructural characteristics of these systems through which the control of the release rates and mechanisms could be achieved have been discussed.In doing so,the effects of(i)the chemistry of the matrix,(ii)porosity,(iii)additives,(iv)drug types,(v)drug concentrations,(vi)drug loading methods and(vii)release media have been distinguished and discussed individually.Kinetic specificities of in vivo release of drugs from CPCs have been reviewed,too.Understanding the kinetic and mechanistic correlations between the CPC properties and the drug release is a prerequisite for the design of bone void fillers with drug release profiles precisely tailored to the application area and the clinical picture.The goal of this review has been to shed light on these fundamental correlations. | Marco Fosca Julietta V.Rau Vuk Uskokovi | 2022 | Bioactive Materials2022，7，1： | 0 |
| 15 | Quality control methods in musculoskeletal tissue engineering:from imaging to biosensors显示文摘Tissue engineering is rapidly progressing toward clinical application.In the musculoskeletal field,there has been an increasing necessity for bone and cartilage replacement.Despite the promising translational potential of tissue engineering approaches,careful attention should be given to the quality of developed constructs to increase the real applicability to patients.After a general introduction to musculoskeletal tissue engineering,this narrative review aims to offer an overview of methods,starting from classical techniques,such as gene expression analysis and histology,to less common methods,such as Raman spectroscopy,microcomputed tomography,and biosensors,that can be employed to assess the quality of constructs in terms of viability,morphology,or matrix deposition.A particular emphasis is given to standards and good practices(GXP),which can be applicable in different sectors.Moreover,a classification of the methods into destructive,noninvasive,or conservative based on the possible further development of a preimplant quality monitoring system is proposed.Biosensors in musculoskeletal tissue engineering have not yet been used but have been proposed as a novel technology that can be exploited with numerous advantages,including minimal invasiveness,making them suitable for the development of preimplant quality control systems. | Daniele Zuncheddu Elena Della Bella Andrea Schwab Dalila Petta Gaia Rocchitta Silvia Generelli Felix Kurth Annapaola Parrilli Sophie Verrier Julietta V.Rau Marco Fosca Margherita Maioli Pier Andrea Serra Mauro Alini Heinz Redl Sibylle Grad Valentina Basoli | 2021 | Bone Research2021，9，4： | 0 |
| 16 | 从烤汉堡的小伙计到麦当劳的掌门人显示文摘今年4月19日,全球餐饮业巨无霸——走当劳60岁的董事长兼CEO 坎塔卢渡突发心脏病去世,公司董事会紧急任命43岁的澳大利亚人查利·贝尔出任新老总。这是麦当劳首位非美籍掌门人。贝尔从15岁在悉尼附近的金斯格罗夫麦当劳餐厅打工到今天坐镇美国芝加哥可谓平步青云。这位昔日在麦当劳扫厕所的新总裁在接受媒体采访时总是提起当年的情景,他希望麦当劳的厕所比其他所有快餐店的厕所都干净,可能正是此种精神成就了他的今天。 | Julietta Jameson Anna Cock 陈树培 | 2004 | 英语文摘2004，0，6： | 0 |
| 17 | Endoscopic management of post-bariatric surgery complications显示文摘Understanding the technical constructs of bariatric surgery is important to the treating endoscopist to maximize effective endoluminal therapy. Post-operative complication rates vary widely based on the complication of interest, and have been reported to be as high as 68% following adjustable gastric banding. Similarly, there is a wide range of presenting symptoms for post-operative bariatric complications, including abdominal pain, nausea and vomiting, dysphagia, gastrointestinal hemorrhage, and weight regain, all of which may provoke an endoscopic assessment. Bleeding and anastomotic leak are considered to be early(< 30 d) complications, whereas strictures, marginal ulcers, band erosions, and weight loss failure or weight recidivism are typically considered late(> 30 d) complications. Treatment of complications in the immediate post-operative period may require unique considerations. Endoluminal therapies serve as adjuncts to surgical and radiographic procedures. This review aims to summarize the spectrum and efficacy of endoscopic management of post-operative bariatric complications. | Mena Boules Julietta Chang Ivy N Haskins Gautam Sharma Dvir Froylich Kevin El-Hayek John Rodriguez Matthew Kroh | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 0 |
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