|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 4 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 5 | Population structure and genetic diversity in insular populations of Nasutitermes takasagoensis (Isoptera Termitidae ) analyzed by AFLP markers 显示文摘 | JULIO G KIYOTO M TORU M | 2002 | Zoological Science2002，19，： | 1 |
| 6 | Determination of Tryptophan by High-performance Liquid Chromatography of Alkaline Hydrolysates With Spectrophotometric Detection 显示文摘 | Maria M Y Justo P Julio G C etal | 2004 | Food Chemistry(S0308-8146)2004，85，2： | 1 |
| 7 | Immobilization ofFe, Mn and Co tetraphenylporphyrin complexes in MCM-41 and their catalytic activity in cyclohexene oxidationreaction by hydrogen peroxide 显示文摘 | Costa A A Grace F G Julio L ei al | 2008 | J Mol Catal A:Chemical2008，282，： | 1 |
| 8 | Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats显示文摘 | CARLA G JULIO R MANUEL G | 2006 | Journal of Ethnopharmacology2006，103，： | 1 |
| 9 | Plasma and tissue glutamine response to acute and chronic supplementation with L-glutamine and L-alanyl-L-glutamine in rats 显示文摘 | Marcelo M R Julio T Rogerio G P | 2004 | Nutrition Res2004，24，4： | 1 |
| 10 | Variation in soil micro-organisms and nutrients underneath and outside the canopy of Adesmia bedwellii (Papilionaceae) shrubs in arid coastal Chile following drought and above average rainfall显示文摘 | LORGIO E A JULIO R G PETER L M | 1999 | Journal of Arid Environments1999，42，： | 1 |
| 11 | Modeling changes of sensory attributes for individual and mixed fresh-cut leafy vegetables显示文摘 | Andrea M P Julio C M Daniel R G | 2005 | Postharvest Biology and Technology2005，，3： | 1 |
| 12 | Processing of spent platinum-based catalysts via fusion with potassium hydrogenosulfate显示文摘 | Sebastiao G Batista J Julio C A | 2010 | Journal of Hazardous Materials2010，184，13： | 1 |
| 13 | Fermentation of cellobiose to ethanol by industrial Saccharomyces strains carrying theβ-glucosidase gene (BGL1) from Saccharomycopsis fibuligera显示文摘 | Leontina G I (A)lvaro L Julio P Julia M N | | 0，，： | 1 |
| 14 | Cerebral white matter is highly vulnerable to ischemia显示文摘 | Julio H G Jorge A G | 1996 | Stroke1996，27，9： | 1 |
| 15 | A monitoring system for intensive agriculture based on mesh networks and the Android system 显示文摘 | Francisco G Montoya Julio G6mez Alejandro Cama | 2013 | Computers and Elec- tronics in Agriculture2013，99，： | 1 |
| 16 | A convenient method to prepare emulsified polyacrylate nanoparticles from for drug delivery applications显示文摘 | Julio C G J Edward T | 2011 | Bioorganic&Medicinal Chemistry Letters2011，21，15： | 1 |
| 17 | Heat shock reduces browning of fresh-cut celery petioles显示文摘 | Julio G L V Mary E Mangrich Reinaldo Campos-Vargas | 2003 | Postharvest Biology and Technology2003，，27： | 1 |
| 18 | Use and application of stem cells in toxicology 显示文摘 | JULIO C GABRIELA G | 2004 | Toxicol Sci2004，79，2： | 1 |
| 19 | Heat shock reduces browning of fresh-cut celery petioles 显示文摘 | JULIO G LOAIZA V MARY E | 2006 | Postharvest Biology and Technology2006，27，： | 1 |
| 20 | Determination of partition and diffusion coefficients of components of two rubber adhesives in different multilayer materials显示文摘 | Nerin C Julio G Paula V | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员