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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 3 | Photochemical reaction involved in the total mineralization of 2,4-DbyFe3+/H20JUV显示文摘 | Sun Yunfu Joseph J P | 1993 | En- vironmental Science Technology1993，27，2： | 1 |
| 4 | Evidence for a surface dual dole -radical me chanism in the TiO2 photocatalytic oxidation of 2,4-Dichlorophenoxyacetic acid显示文摘 | Yunfu Sun Joseph J Pignatello | 1995 | Environ Sci Technol1995，29，8： | 1 |
| 5 | Synthesis, Structure, and Extraction Properties of paco-Calix[4]arene Crown-6 Ethers显示文摘 | Richard A. Sachleben Jeffrey C. Bryan Goutam Das Tanneguy Descazeaud Yunfu Sun Bruce A. Moyer | 2002 | Journal of Inclusion Phenomena and Macrocyclic Chemistry (-)2002，，1： | 1 |
| 6 | MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells显示文摘 | Junjie Xiao Dandan Liang Hong Zhang Ying Liu Dasheng Zhang Yi Liu Lei Pan Xiaoli Chen Pieter A. Doevendans Yunfu Sun Xingqun Liang Joost P.G. Sluijter Yi-Han Chen | 2012 | Journal of Molecular and Cellular Cardiology2012，，6： | 1 |
| 7 | Photochemical reaction involved in the total mineralization of 2,4 - D by Fe^3 +/H2O2/UV 显示文摘 | Sun Yunfu Joseph J P | 1993 | Environmental Science Technology1993，27，2： | 1 |
| 8 | Photochemical reactions involved in the total mineralization of 2,4-D by iron(3+)/hydrogen peroxide/UV显示文摘 | SUN Yunfu PIGNATELLO J J | 1993 | Environmental Science&Technology1993，27，2： | 1 |
| 9 | Photochemical reaction involved in the total mineralization of 2,4-D by Fe3+/H2O2/UV显示文摘 | Sun Yunfu Pignatello Joseph J | 1993 | Environ Sci Technol1993，27，2： | 1 |
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