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| 1 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 2 | Effect of angiotensin Ⅱ type 1 receptor blocker and angiotensin converting enzyme inhibitor on the intraocular growth factors and their receptors in streptozotocin-induced diabetic rats显示文摘AIM: To investigate the effect of angiotensinⅡ type 1 receptor blocker(ARB) and angiotensin converting enzyme inhibitor(ACEI) on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats. METHODS: Forty Sprague-Dawley rats were divided into 4 groups: control, diabetes mellitus(DM), candesartantreated DM, and enalapril-treated DM(each group, n=10). After the induction of DM by streptozotocin, candesartan [ARB, 5 mg/(kg·d)] and enalapril [ACEI, 10 mg/(kg·d)] were administered to rats orally for 4wk. Vascular endothelial growth factor(VEGF) and angiotensin Ⅱ(Ang Ⅱ) concentrations in the vitreous were measured using enzyme-linked immunosorbent assays, and VEGF receptor 2 and angiotensin II type 1 receptor(AT1R) levels were assessed at week 4 by Western blotting. RESULTS: Vitreous Ang Ⅱ levels were significantly higher in the DM group and candesartan-treated DM group than in the control(P=0.04 and 0.005, respectively). Vitreous AT1R increased significantly in DM compared to the other three groups(P<0.007). Candesartan-treated DM rats showed higher vitreal AT1R concentration than the enalapril-treated DM group and control(P<0.001 and P=0.005, respectively). No difference in vitreous Ang Ⅱ and AT1R concentration was found between the enalapriltreated DM group and control. VEGF and its receptor were below the minimum detection limit in all 4 groups.CONCLUSION: Increased Ang Ⅱ and AT1R in the hyperglycemic state indicate activated the intraocular renin-angiotensin system, which is inhibited more effectively by systemic ACEI than systemic ARB. | Ik Soo Byon Dong Hyun Lee Eun Sook Jun Min Kyu Shin Sung Who Park Ji Eun Lee | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 5 |
| 3 | Predictors of post-treatment stenosis in cervical esophageal cancer undergoing high-dose radiotherapy显示文摘AIM To evaluate toxicity and treatment outcome of highdose radiotherapy(RT) for cervical esophageal cancer(CEC).METHODS We reviewed a total of 62 consecutive patients who received definitive RT for stage Ⅰ to Ⅲ cervical esophageal cancer between 2001 and 2015. Patients who received < 45 Gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded. Treatment failures were divided into local(occurring within the RT field), outfield-esophageal, and regional [occurring in regional lymph node(s)] failures. Factors predictive of esophageal stenosis requiring endoscopic dilation were analyzed.RESULTS Grade 1, 2, and 3 esophagitis occurred in 19(30.6%), 39(62.9%), and 4 patients(6.5%), respectively, without grade ≥ 4 toxicities. Sixteen patients(25.8%) developed post-RT stenosis, of which 7 cases(43.8%) were malignant. Four patients(6.5%) developed tracheoesophageal fistula(TEF), of which 3(75%) cases were malignant. Factors significantly correlated with post-RT stenosis were stage T3/4(P = 0.001), complete circumference involvement(P < 0.0001), stenosis at diagnosis(P = 0.024), and endoscopic complete response(P = 0.017) in univariate analysis, while complete circumference involvement was significant in multivariate analysis(P = 0.003). A higher dose(≥ 60 Gy) was not associated with occurrence of postRT stenosis or TEF. With a median follow-up of 24.3(range, 3.4-152) mo, the 2 y local control, outfield esophageal control, progression-free survival, and overall survival(OS) rates were 78.9%, 90.2%, 49.6%, and 57.3%, respectively. Factors significantly correlated with OS were complete circumference involvement(P = 0.023), stenosis at diagnosis(P < 0.0001), and occurrence of post-RT stenosis or TEF(P < 0.001) in univariate analysis, while stenosis at diagnosis(P = 0.004) and occurrence of post-RT stenosis or TEF(P = 0.023) were significant in multivariate analysis. CONCLUSION Chemoradiation for CEC was well tolerated, and a higher dose was not associated with stenosis. Patients with complete circumferential involvement require close follow-up. | Jun Won Kim Tae Hyung Kim Jie-Hyun Kim Ik Jae Lee | 2018 | World Journal of Gastroenterology2018，24，7： | 3 |
| 4 | Porous hydroxyapatite scaffolds coated with bioactive apatite wollastonite glass ceramics 显示文摘 | Jun IK Song JH Choi WY | 2007 | Journal of the American Ceramic Society2007，90，： | 1 |
| 5 | Fabrication of poly (ε-caprolactone)/hydroxyapatite scaffold using rapid direct deposition显示文摘 | Koh YH Jun IK Kim HE | | 0，，10： | 1 |
| 6 | Porous hydroxyapatite scaffolds coated with bioaetive apatite?wollastonite glass?ceramics显示文摘 | Jun IK Song JH Choi WY | 2007 | J Am Ceram Soc2007，90，9： | 1 |
| 7 | Herogeneous liquid-phase lactonization of 1,4-butadiol using H3+xPMo12-xVxO40 (x = 0 - 3) catalyst immobilized on polyaniline显示文摘 | Seong Soo Lim Gyo Ik Park Jun Seon Choi | 2002 | Catalysis Today2002，74，： | 1 |
| 8 | Design for a simplified cochlear implant system 显示文摘 | Soon Kwan An Se - Ik park Sang Beom Jun | 2007 | IEEE Transactions on biomedical engineering2007，54，6： | 1 |
| 9 | Transmittance optimized nb-doped TiO 2 /Sn-doped In 2 O 3 multilayered photoelectrodes for dye-sensitized solar cells显示文摘 | Dong Hoe Kim Sangwook Lee Jong Hoon Park Jun Hong Noh Ik Jae Park Won Mo Seong Kug Sun Hong | 2011 | Solar Energy Materials and Solar Cells2011，，1： | 1 |
| 10 | Stercoral perfora- tion of the colon in sigmoid colostomy patients: Two case reports 显示文摘 | Young Wan Kim Hyun Jun Kwon Ik Yong Kim | 2013 | International Journal of Surgery Case Reports2013，4，11： | 1 |
| 11 | Detection of colorectal adenomas by routine chromoendoscopy with indigocarmine显示文摘 | Jun Haeng Lee Jeong Wook Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Eun Yoon Cho | 2003 | The American Journal of Gastroenterology2003，，6： | 1 |
| 12 | Riesz idempotent and Weyl's Theorem for w-hyponormal operators 显示文摘 | Han Young Min Lee Jun IK Wang Derming | 2005 | Integral Equations and Operator Theory2005，53，： | 1 |
| 13 | Phase II study of docetaxel,cisplatin,and 5 - FU inductionchemotherapy followed by chemoradiotherapy in locoregionailyadvanced nasopharyngealcancer 显示文摘 | Woo Kyun Bae Jun Eul Hwang Hyun Jeong Shim Sang Hee Cho Joon Kyoo Lee Sang - Chul Lim Woong - Ki Chung Ik - JooChung | 2010 | Cancer Chemotherapy andPharmacology2010，12，3： | 1 |
| 14 | A randomised clinical trial of 10-day concomitant therapy and standard triple therapy for Helicobacter pylori eradication显示文摘 | Jun Heo Seong Woo Jeon Jin Tae Jung Joong Goo Kwon Eun Young Kim Dong Wook Lee Hyang Eun Seo Chang Yoon Ha Hyun Jin Kim Eun Soo Kim Kyung Sik Park Kwang Bum Cho Si Hyung Lee Byung Ik Jang | 2014 | Digestive and Liver Disease2014，，11： | 1 |
| 15 | Effects of UCP2 and UCP3 variants on the manifestation of overweight in Korean children显示文摘 | Jun HS Kim IK Lee HJ | 2009 | Obesity2009，17，2： | 1 |
| 16 | Suppression of narrow-band inter- ference in DS- spread spectrum systems using adaptive IIR notch filter显示文摘 | Jun Won Choi Nam Ik Cho | 2002 | Signal Processing2002，82，2002： | 1 |
| 17 | Suppression of Narrow-Bandinterference in DS-Spreadspectrum Systems Using Adaptive IIR Notch Filter 显示文摘 | JUN WON CHOI NAM IK CHO | 2002 | Signal Processing2002，82，12： | 1 |
| 18 | 显示文摘 | Joo Ik Kim Yong Joo Jun | 2004 | Polymer2004，45，： | 1 |
| 19 | Renal outcomes in patients with type 2 diabetes with or without coexisting non-diabetic renal disease显示文摘 | Tae Ik Chang Jung Tak Park Jwa-kyung Kim Seung Jun Kim Hyung Jung Oh Dong Eun Yoo Seung Hyeok Han Tae-Hyun Yoo Shin-Wook Kang | 2011 | Diabetes Research and Clinical Practice2011，，2： | 1 |
| 20 | Effects of UCP2 and UCP3 variants on the manifestation of overweight in Korean children显示文摘 | Jun HS Kim IK Lee H J | 2009 | Obesity ( Silver Spring)2009，17，： | 1 |
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