|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis显示文摘AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients. | Soon Kyu Lee Myeong Jun Song Seok Hyun Kim Byung Seok Lee Tae Hee Lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae Soon Young Ko Jae Dong Lee | 2017 | World Journal of Gastroenterology2017，23，13： | 14 |
| 2 | Pancreatic stents for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis should be inserted up to the pancreatic body or tail显示文摘AIM To investigate the location to which a pancreatic stent should be inserted to prevent post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS Over a ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had a pancreatic stent inserted; this study included 147 patients who had ERCP performed primarily for biliary investigation and had a pancreatic stent inserted to prevent PEP. We dividedthese patients into two groups: 131 patients with a stent inserted into the pancreatic head(head group) and 16 patients with a stent inserted up to the pancreatic body or tail(body/tail group). Patient characteristics and ERCP factors were compared between the groups.RESULTS Pancreatic amylase isoenzyme(p-AMY) levels in the head group were significantly higher than those in the body/tail group [138.5(7.0-2086) vs 78.5(5.0-1266.5), P = 0.03] [median(range)]. No cases of PEP were detected in the body/tail group [head group, 12(9.2%)]. Of the risk factors for post-ERCP hyperamylasemia(≥ p-AMY median, 131 IU/L), procedure time ≥ 60 min [odds ratio(OR) 2.65, 95%CI: 1.17-6.02, P = 0.02) and stent insertion into the pancreatic head(OR 3.80, 95%CI: 1.12-12.9, P = 0.03) were identified as independent risk factors by multivariate analysis.CONCLUSION Stent insertion up to the pancreatic body or tail reduces the risk of post-ERCP hyperamylasemia and may reduce the risk of PEP. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto Hikichi Hiromasa Ohira | 2018 | World Journal of Gastroenterology2018，24，22： | 13 |
| 3 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 4 | Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading显示文摘AIM: To evaluate the efficacy of endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) for grading pancreatic neuroendocrine tumors(PNETs).METHODS: A total of 22 patients were diagnosed with PNET by EUS-FNA between October 2001 and December 2013 at Fukushima Medical University Hospital.Among these cases,we targeted 10 PNET patients who were evaluated according to the World Health Organization(WHO) 2010 classification.Surgery was performed in eight patients,and chemotherapy was performed in two patients due to multiple liver metastases.Specimens obtained by EUS-FNA were first stained with hematoxylin and eosin and then stained with chromogranin,synaptophysin,CD56,and Ki-67.The specimens were graded by the Ki-67 index according to the WHO 2010 classification.Specimens obtained by surgery were graded by the Ki-67 indexand mitotic count(WHO 2010 classification).For the eight specimens obtained by EUS-FNA,the Ki-67 index results were compared with those obtained by surgery.In the two cases treated with chemotherapy,the effects and prognoses were evaluated.RESULTS: The sampling rate for histological diagnosis by EUS-FNA was 100%.No adverse effects were observed.The concordance rate between specimens obtained by EUS-FNA and surgery was 87.5%(7/8).Fo r t h e t w o c a s e s t re a t e d w i t h c h e m o t h e ra p y,case 1 received somatostatin analog therapy and transcatheter arterial infusion(TAI) targeting multiple liver metastases.Subsequent treatment consisted of everolimus.During chemotherapy,the primary tumor remained unconfirmed,although the multiple liver metastases diminished dramatically.Case 2 was classified as neuroendocrine carcinoma(NEC) according to the Ki-67 index of a specimen obtained by EUS-FNA; therefore,cisplatin and irinotecan therapy was started.However,severe adverse effects,including renal failure and diarrhea,were observed,and the therapy regimen was changed to cisplatin and etoposide.TAI targeting multiple liver metastases was performed.Although the liver metastases diminished,the primary tumor remained unconfirmed.These chemotherapy regimens had immediate effects for both unresectable neuroendocrine tumor(NET) and NEC cases.These two subjects are still alive.CONCLUSION: EUS-FNA was effective for PNET diagnosis and Ki-67 index grading for WHO 2010 classification,enabling informed decisions on unresectable PNET treatment by identifying NET or NEC. | Mitsuru Sugimoto Tadayuki Takagi Takuto Hikichi Rei Suzuki Ko Watanabe Jun Nakamura Hitomi Kikuchi Naoki Konno Yuichi Waragai Hiroyuki Asama Mika Takasumi Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
| 5 | Efficacy and cost analysis of transrectal ultrasound-guided prostate biopsy under monitored anesthesia显示文摘镇静可以在指导的 transrectal 超声(TRUS ) 期间疼痛地导致减小前列腺活体检视。我们试图在在护理费用的指导 TRUS 的前列腺活体检视和相关增加期间评估 propofol 和 remifentanil 注入的联合的功效和安全。从 1 月到 2010 年 9 月,经历 transrectal 前列腺活体检视的 100 个人被使随机化进二个组。在组 1, 50 个病人收到了 propofol 和 remifentanil 的联合注入;在组 2, 50 个病人收到了 lidocaine 果冻。在指导 TRUS 的活体检视被执行以后,疼痛和耐心的满足被一个 10 点评估视觉模拟规模(管) ,和一张费用相关的耐心的满足问询表被所有病人完成。病人们也被问他们是否将愿意由一样的方法经历重复活体检视。在 1 看了显著地更低的管的组的病人在组 2 比那些得分(吝啬的管分数:0.9 ± 1.1 对 6.3 ± 2.5;P< 0.001 ) 。另外,耐心的满足规模在组 1 是显著地更高的(P=0.002 ) 。尽管全面费用在组 1 是显著地更高的(P=0.006 ) ,就费用而言的耐心的满足规模在这个组(P=0.009 ) 也是更高的。propofol 和 remifentanil 的联合在指导 TRUS 的前列腺活体检视期间是到减少病人疼痛和增加病人满足的一条安全、有效的路。尽管费用在收到了镇静,期望的组是更高的,病人展出了提高的满足和心甘情愿由一样的方法重复活体检视。 | Sung Gu Kang Bum Sik Tae Sam Hong Min Young Hwii Ko Seok Ho Kang Jeong Gu Lee Je Jong Kim Jun Cheon | 2011 | Asian Journal of Andrology2011，13，5： | 5 |
| 6 | An automated spring-loaded needle for endoscopic ultrasound-guided abdominal paracentesis in cancer patients显示文摘AIM: To evaluate the feasibility of using an automatedspring-loaded needle device for endoscopic ultrasound(EUS)-guided abdominal paracentesis(EUS-P) to see if this would make it easier to puncture the mobile and lax gastric wall for EUS-P.METHODS: The EUS database and electronic medical records at Fukushima Medical University Hospital were searched from January 2001 to April 2011. Patients with a history of cancer and who underwent EUS-P using an automated spring-loaded needle device with a 22-gauge puncture needle were included. The needle was passed through the instrument channel and advanced through the gastrointestinal wall under EUS guidance into the echo-free space in the abdominal cavity and ascitic fluid was collected. The confirmed diagnosis of malignant ascites included positive cytology and results from careful clinical observation for at least 6 mo in patients with negative cytology. The technical success rate, cytology results and complications were evaluated.RESULTS: We found 11 patients who underwent EUS-P with an automated spring-loaded needle device. In 4 cases, ascites was revealed only with EUS but not in other imaging modalities. EUS-P was done in 7 other cases because there was minimal ascitic fluid and no safe window for percutaneous abdominal aspiration. Ascitic fluid was obtained in all cases by EUS-P. The average amount aspirated was 14.1 mL(range 0.5-38 mL) and that was sent for cytological exam. The etiology of ascitic fluid was benign in 5 patients and malignant in 6. In all cases, ascitic fluid was obtained with the first needle pass. No procedure-related adverse effects occurred.CONCLUSION: EUS-P with an automated springloaded needle device is a feasible and safe method for ascites evaluation. | Rei Suzuki Atsushi Irisawa Manoop S Bhutani Takuto Hikichi Tadayuki Takagi Goro Shibukawa Ai Sato Masaki Sato Tsunehiko Ikeda Ko Watanabe Jun Nakamura Srinadh Annangi Kazuhiro Tasaki Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 3 |
| 7 | The biochemical efficacy of primary cryoablation combined with prolonged total androgen suppression compared with radiotherapy on high-risk prostate cancer: a 3-year pilot study显示文摘为了在高风险的前列腺癌症,联合本地治疗的一条综合途径和雄激素剥夺治疗(ADT ) 的管理获得有益的效果,被使用。我们比较了在与与 ADT 相结合的延长 ADT 和放射相结合的前列腺(CSAP ) 的主要 cryosurgical 脱离之间的生物化学的回答,它是在高风险的疾病的确定的形式。收到的 CSAP 在治疗以后与 ADT 相结合 3 个月在前并且直到 24 个月的 33 个高风险的病人的一个总数。这个耐心的组与另外一个被匹配为 ADT 与一样的协议经历了三维的保角的放射治疗(3D-CRT ) 的 33 个病人。生物化学的复发(BCR ) 被美国社会为治疗学的放射肿瘤学(ASTRO ) 估计 0.5 ng mL 的定义,菲尼克斯定义和前列腺特定的抗原(PSA ) 截止 ? 1。中部的后续是为 CSAP + ADT 的 11.9 个月组织的 61.0 卤和为 3D-CRT + ADT 的 15.8 个月组织的 86.0 卤。在 CSAP 组,包括 rectourethral 管和不能自制的主要复杂并发症没被注意。在 CSAP + ADT 组, 57.0% 用 ASTRO 定义有 BCR, 21.2% 使用菲尼克斯定义并且 54.5% 使用 0.5 ng mL 的 PSA 截止 ? 1。在 3D-CRT + ADT 组, 54.5% , 21.2% 和 54.5% 分别地用 ASTRO,菲尼克斯和 PSA 定义有 BCR。在 CSAP + ADT 组, BCR 免费的幸存(BRFS ) 是 54 卤用 ASTRO 定义的 10 个月, 65 卤用菲尼克斯定义的 5 个月和 51 卤用 0.5 ng mL 的 PSA 截止的 4 个月 ? 1。在 3D-CRT + ADT 组, BRFS 是 68 卤 12, 93 卤 19 和 70 卤分别地使用 ASTRO,菲尼克斯和 PSA 定义的 18 个月。由木头等级测试,为每个组的 BRFS 价值不是统计上不同的。这中间术语的结果显示与延长 ADT 相结合的主要 CSAP 在高风险的前列腺癌症与放射疗法相比提供平行生物化学的回答。 | Young Hwii Ko Seok Ho Kang Young Je Park Hong Seok Park Du Geon Moon Jeong Gu Lee Duck Ki Yoon Je Jong Kim Jun Cheon | 2010 | Asian Journal of Andrology2010，12，6： | 3 |
| 8 | A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro显示文摘Neuromodulation by ultrasound has recently received attention due to its noninvasive stimulation capability for treating brain diseases.Although there have been several studies related to ultrasonic neuromodulation,these studies have suffered from poor spatial resolution of the ultrasound and low repeatability with a fixed condition caused by conventional and commercialized ultrasound transducers.In addition,the underlying physics and mechanisms of ultrasonic neuromodulation are still unknown.To determine these mechanisms and accurately modulate neural circuits,researchers must have a precisely controllable ultrasound transducer to conduct experiments at the cellular level.Herein,we introduce a new MEMS ultrasound stimulation system for modulating neurons or brain slices with high spatial resolution.The piezoelectric micromachined ultrasonic transducers(pMUTs)with small membranes(submm membranes)generate enough power to stimulate neurons and enable precise modulation of neural circuits.We designed the ultrasound transducer as an array structure to enable localized modulation in the target region.In addition,we integrated a cell culture chamber with the system to make it compatible with conventional cell-based experiments,such as in vitro cell cultures and brain slices.In this work,we successfully demonstrated the functionality of the system by showing that the number of responding cells is proportional to the acoustic intensity of the applied ultrasound.We also demonstrated localized stimulation capability with high spatial resolution by conducting experiments in which cocultured cells responded only around a working transducer. | Jungpyo Lee Kyungmin Ko Hyogeun Shin Soo-Jin Oh CJustin Lee Namsun Chou Nakwon Choi Min Tack Oh Byung Chul Lee Seong Chan Jun Il-Joo Cho | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 9 | Predictive factors for the failure of endoscopic stent-instent self-expandable metallic stent placement to treat malignant hilar biliary obstruction显示文摘AIM To investigate the factors predictive of failure when placing a second biliary self-expandable metallic stents(SEMSs). METHODS This study evaluated 65 patients with an unresectable malignant hilar biliary obstruction who were examined in our hospital. Sixty-two of these patients were recruited to the study and divided into two groups: the success group, which consisted of patients in whom a stent-in-stent SEMS had been placed successfully, and the failure group, which consisted of patients in whom the stent-in-stent SEMS had not been placed successfully. We compared the characteristics of the patients, the stricture state of their biliary ducts, and the implemented endoscopic retrograde cholangiopancreatography(ERCP) procedures between the two groups.RESULTS The angle between the target biliary duct stricture and the first implanted SEMS was significantly larger in the failure group than in the success group. There were significantly fewer wire or dilation devices(ERCP catheter, dilator, or balloon catheter) passing the first SEMS cell in the failure group than in the success group. The cut-off value of the angle predicting stent-in-stent SEMS placement failure was 49.7 degrees according to the ROC curve(sensitivity 91.7%, specificity 61.2%). Furthermore, the angle was significantly smaller in patients with wire or dilation devices passing the first SEMS cell than in patients without wire or dilation devices passing the first SEMS cell. CONCLUSION A large angle was identified as a predictive factor for failure of stent-in-stent SEMS placement. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Yuki Sato Takuto Hikichi Hiromasa Ohira | 2017 | World Journal of Gastroenterology2017，23，34： | 3 |
| 10 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 11 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 12 | Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection:A 15-year observational study显示文摘BACKGROUND Surgical resection is one of the most widely used modalities for the treatment of hepatocellular carcinoma(HCC).Early extrahepatic recurrence(EHR)of HCC after surgical resection is considered to be closely associated with poor prognosis.However,data regarding risk factors and survival outcomes of early EHR after surgical resection remain scarce.AIM To investigate the clinical features and risk factors of early EHR and elucidate its association with survival outcomes.METHODS From January 2004 to December 2019,we enrolled treatment-naïve patients who were≥18 years and underwent surgical resection for HCC in two tertiary academic centers.After excluding patients with tumor types other than HCC and/or ineligible data,this retrospective study finally included 779 patients.Surgical resection of HCC was performed according to the physicians’decisions and the EHR was diagnosed based on contrast-enhanced computed tomography or magnetic resonance imaging,and pathologic confirmation was performed in selected patients.Multivariate Cox regression analysis was performed to identify the variables associated with EHR.RESULTS Early EHR within 2 years after surgery was diagnosed in 9.5%of patients during a median followup period of 4.4 years.The recurrence-free survival period was 5.2 mo,and the median time to EHR was 8.8 mo in patients with early EHR.In 52.7%of patients with early EHR,EHR occurred as the first recurrence of HCC after surgical resection.On multivariate analysis,serum albumin<4.0 g/dL,serum alkaline phosphatase>100 U/L,surgical margin involvement,venous and/or lymphatic involvement,satellite nodules,tumor necrosis detected by pathology,tumor size≥7 cm,and macrovascular invasion were determined as risk factors associated with early EHR.After sub-categorizing the patients according to the number of risk factors,the rates of both EHR and survival showed a significant correlation with the risk of early EHR.Furthermore,multivariate analysis revealed that early EHR was associated with substantially worse survival outcomes(Hazard ratio,6.77;95%confidence interval,4.81-9.52;P<0.001).CONCLUSION Early EHR significantly deteriorates the survival of patients with HCC,and our identified risk factors may predict the clinical outcomes and aid in postoperative strategies for improving survival. | Jae Hyun Yoon Sung Kyu Choi Sung Bum Cho Hee Joon Kim Yang Seok Ko Chung Hwan Jun | 2022 | World Journal of Gastroenterology2022，28，36： | 2 |
| 13 | Endoscopic therapy for esophageal hematoma with blue rubber bleb nevus syndrome显示文摘A 57-year-old woman previously diagnosed with blue rubber bleb nevus syndrome(BRBNS) reported hematemesis. BRBNS is a rare vascular anomaly syndrome consisting of multifocal hemangiomas of the skin and gastrointestinal(GI) tract but her GI tract had never been examined. An upper gastrointestinal endoscopy revealed a large bleeding esophageal hematoma positioned between the thoracic esophagus and the gastric cardia. An endoscopic injection of polidocanol was used to stop the hematoma from bleeding. The hematoma was incised using the injectionneedle to reduce the pressure within it. Finally, argon plasma coagulation(APC) was applied to the edge of the incision. The esophageal hematoma disappeared seven days later. Two months after the endoscopic the rapy, the eso phage alulcerhealed and the hemangioma did not relapse. This rare case of a large esophageal hematoma originating from a hemangioma with BRBNS was treated using a combination of endoscopic therapy with polidocanol injection, incision, and APC. | Mika Takasumi Takuto Hikichi Tadayuki Takagi Masaki Sato Rei Suzuki Ko Watanabe Jun Nakamura Mitsuru Sugimoto Yuichi Waragai Hitomi Kikuchi Naoki Konno Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 2 |
| 14 | Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue显示文摘在多细胞的有机体,控制预定和不对称的细胞部门(ACD ) 的程度为正确 patterning 是关键的。在在 Arabidopsis thaliana 的 embryonic 以后根开发期间,地面织物(GT ) 成熟包含内皮的另外的 ACD,它产生二不同纸巾:内皮(内部) 并且中间的外皮(外部) 。这被报导了 abscisic 酸(骆驼毛的织物) 和赤霉素(GA ) 小径涉及中间的外皮(MC ) 形成。然而,在 GT 成熟期间位于在骆驼毛的织物和 GA 之间的相互作用下面的分子的机制仍然保持大部分未知。通过 transcriptome 分析,我们识别了一以前 uncharacterized C 2 H 2-type 锌手指基因,其表情被 GA 和骆驼毛的织物调整,因此命名的 GAZ (GA- 和骆驼毛的织物应答的锌手指) 。幼苗宫外地 overexpressing GAZ (GAZ 公牛) 在 MC 形成期间对骆驼毛的织物和 GA 敏感,而 GAZ-SRDX 和 RNAi 幼苗显示了相反的显型。另外,我们的结果显示 GAZ 涉及骆驼毛的织物和 GA 动态平衡的 transcriptional 规定。与那件骆驼毛的织物和 GA 协调控制预定 MC 形成的以前的研究一致,我们也证实了在骆驼毛的织物和 GA 之间的唯一的相互影响并且识别了在 Arabidopsis 根的 GT 成熟期间衔接二条荷尔蒙小径的因素和规章的网络。 | Shin Ae Lee Sejeong Jang Eun Kyung Yoon Jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok Heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim | 2016 | Molecular Plant2016，9，6： | 2 |
| 15 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 16 | Preparation of size-controlled bovine serum albumin (BSA) nanoparticles by a modified desolvation method显示文摘 | Ji Yeon Jun Hoang Hai Nguyen Sae-Yeol-Rim Paik Hyang Sook Chun Byeong-Cheol Kang Sanghoon Ko | 2011 | Food Chemistry2011，，4： | 1 |
| 17 | High prevalence of antimicrobialresistance among clinical Streptococcus pneumoniae isolate in Asia显示文摘 | Song JH Jun SI Ko KS | | 0，，06： | 1 |
| 18 | Comparison of EGF with VEGF non-viral gene therapy for cutaneous wound healing of streptozotocin diabetic mice 显示文摘 | Ko J Jun H Chung H | 2011 | Diabetes Metab J2011，35，3： | 1 |
| 19 | Endovascular treatment of medically refractory cerebral vasospasm following aneurysmal subarachnoid hemorrhage显示文摘 | Jun P Ko NU English JD | 2010 | AJNR Am J Neuroradiol2010，31，10： | 1 |
| 20 | Changing pattern of antibiotic resistance of H elicobacter pylori in children during 20 years in J inju, S outh K orea显示文摘 | Ji‐Hyun Seo Jin‐Su Jun Jung Sook Yeom Ji Sook Park Hee‐Shang Youn Gyung‐Hyuck Ko Seung‐Chul Baik Woo‐Kon Lee Myung‐Je Cho Kwang‐Ho Rhee | 2013 | Pediatr Int2013，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员