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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 3 | Second-look endoscopy with prophylactic hemostasis is still effective after endoscopic submucosal dissection for gastric neoplasm显示文摘AIM: The clinical value of second-look endoscopy(SLE) after endoscopic submucosal dissection(ESD) has been doubted continuously. The aim of this study was to assess the effectiveness of SLE based on the risk of delayed bleeding after ESD. METHODS: A total of 310 lesions of gastric epithelial neoplasms treated by ESD were reviewed. The lesions were divided into two groups based on the risk of postprocedural bleeding estimated by Forrest classification. The high risk of rebleeding group(Forrest?Ⅰa,?Ⅰb and Ⅱa) required endoscopic treatment, while the low risk of rebleeding group(Forrest Ⅱb, Ⅱc and Ⅲ) did not. Delayed bleeding after ESD was investigated. RESULTS: Sixty-six lesions were included in the high risk of rebleeding group and 244 lesions in the low risk of rebleeding group. There were no significant differences in delayed bleeding between the high risk group(1/66) and the low risk group(1/244)(P = 0.38). The high risk of rebleeding group tended to be located more often in the mid-third and had higher appearance of flat or depressed shape than the low risk group(P = 0.004 and P = 0.006, respectively). CONCLUSION: SLE with pre-emptive prophylactic endoscopic treatment is still effective in preventing delayed bleeding after ESD. | Ji Hye Jung Beom Jin Kim Chang Hwan Choi Jae G Kim | 2015 | World Journal of Gastroenterology2015，21，48： | 3 |
| 4 | MR-arterioportography: A new technical approach for detection of liver lesions显示文摘AIM: To evaluate the benefit and effectiveness of MRarterioportography (MR-AP) to achieve the highest sensitivity for detection and evaluation of hepatocellular carcinoma (HCC). METHODS: Twenty liver cirrhosis patients with suspected HCC were included before transarterial chemoembolization. In all patients double-enhanced Magnetic resonance imaging (MRI) was performed. A bolus of 10 mL Magnevist was injected through a selectively placed catheter in the superior mesenteric artery and MRI of the liver was performed in arterioportographic phase. Two independent readers evaluated number, size and localization of detected lesions. Diagnostic quality was determined using a 4-point scale. Differences were analyzed for significance using a t -test. Interobserver variability was calculated. RESULTS: In all 20 patients (100%), MR-AP was feasible. Diagnostic quality was, in all cases, between 1 and2 for both modalities and readers. MR-AP detected significantly more lesions than double-enhanced MRI (102.5 vs 61, respectively, P < 0.0024). The inter-observer variability was 0.881 for MRI and 0.903 for MR-AP. CONCLUSION: Our study confirmed that the MR-AP as an additional modality for detection of HCC is beneficial, as significantly more lesions were detected compared to MRI with liver-specific contrast. | Janine Rennert Ernst-Michael Jung Andreas G Schreyer Patrick Hoffstetter Peter Heiss Stefan Feuerbach Niels Zorger | 2011 | World Journal of Gastroenterology2011，17，13： | 2 |
| 5 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 6 | Protective effect of an antioxidative peptide purified from gastrointestinal digests of oyster, Crassostrea gigas against free radical induced DNA damage显示文摘 | QIAN Z J JUNG W K BYUN H G | 2008 | Bioresouree Technology2008，99，9： | 1 |
| 7 | Low expression of p27(Kip1) in advanced mucoepidermoid carcinoma of head and neck显示文摘 | Choi G Jung KY | 2001 | Head Neck2001，23，4： | 1 |
| 8 | Surface Status and Size Influences of Nickel Nanoparticles on Sulfur Compound Adsorption 显示文摘 | Chang H K Jung G P Ji C P | 2007 | Applied Surface Science2007，253，13： | 1 |
| 9 | Force tracking impedance control of robot manipulators trader unknown environment 显示文摘 | JUNG S HSIA T C BONITZ R G | 2004 | IEEE Transactions on Control Systems Technology2004，12，3： | 1 |
| 10 | Analysis of fMRI data by blind separation into independent spatial components 显示文摘 | Mckeown M J Makelg S Brown G G Jung T P Kinderman S S Bell A J and Sejnowski T J | 1998 | Human Brain Mapping1998，6，： | 1 |
| 11 | CpG island methylation in premalignant stages of stages of gastric carcinoma显示文摘 | Kang G H Shim T H Jung H Y | 2001 | Cancer Res2001，61，7： | 1 |
| 12 | Low expression of p27 (Kipl) in advanced mucoepidermoid carcinomas of head and neck显示文摘 | Choi C S Choi G Jung K Y | 2001 | Head Neck2001，23，4： | 1 |
| 13 | Tissue ischemia time af-fects gene and protein expression patterns within minutes followingsurgical tumor excision显示文摘 | Spruessel A Steimann G Jung M | 2004 | Biotechniques2004，36，6： | 1 |
| 14 | Scanning Laser Radar Based Target Position Designation for Parking Aid System显示文摘 | JUNG H G CHOYH YOON P J | 2008 | Intelligent Transportation Systems2008，9，3： | 1 |
| 15 | High- performance graphene field-effect transistors with ex- tremely small access length using self-aligned source and drain technique 显示文摘 | JUNG M H PARK G H YOSHIDA T | 2013 | Proceedings of IEEE2013，101，7： | 1 |
| 16 | A study on thermal characteristic analysis and shape optimization of a ventilated disc显示文摘 | JUNG S P KIM Y G PARK T W | | 0，，01： | 1 |
| 17 | Effect of chromi- um on the corrosion behavior of low-alloy steels con- taining copper in FGD environment显示文摘 | PARK S A WOO S J JUNG G K | 2013 | Int J Electro- chem Sci2013，8，： | 1 |
| 18 | Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesis显示文摘 | Izhak L Wildbaum G Jung S | 2012 | PLo S One2012，7，28： | 1 |
| 19 | A Nonlinear Viscoelastic Constitu- tive Model of Solid Propellant 显示文摘 | Jung G D Youn S K | 1999 | International Journal of Solids and Structures1999，36，25： | 1 |
| 20 | Dry-contact and noncontact biopotential electrodes: methodological review 显示文摘 | Chi Y M Jung T P Cauwenberghs G | 2009 | IEEE Reviews in Biomedical Engineering2009，，3： | 1 |
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