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| 1 | Ig SF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95显示文摘Osteoclasts are multinucleated, giant cells derived from myeloid progenitors. While receptor activator of NF-κB ligand(RANKL)stimulation is the primary driver of osteoclast differentiation, additional signaling further contributes to osteoclast maturation.Here, we demonstrate that immunoglobulin superfamily member 11(Ig SF11), whose expression increases during osteoclast differentiation, regulates osteoclast differentiation through interaction with postsynaptic density protein 95(PSD-95), a scaffold protein with multiple protein interaction domains. Ig SF11 deficiency in vivo results in impaired osteoclast differentiation and bone resorption but no observed defect in bone formation. Consequently, Ig SF11-deficient mice exhibit increased bone mass.Using in vitro osteoclast culture systems, we show that Ig SF11 functions through homophilic interactions. Additionally, we demonstrate that impaired osteoclast differentiation in Ig SF11-deficient cells is rescued by full-length Ig SF11 and that the Ig SF11-PSD-95 interaction requires the 75 C-terminal amino acids of Ig SF11. Our findings reveal a critical role for Ig SF11 during osteoclast differentiation and suggest a role for Ig SF11 in a receptor-and signal transduction molecule-containing protein complex. | Hyunsoo Kim Noriko Takegahara Matthew CWalsh Sarah AMiddleton Jiyeon Yu Jumpei Shirakawa Jun Ueda Yoshitaka Fujihara Masahito Ikawa Masaru Ishii Junhyong Kim Yongwon Choi | 2020 | Bone Research2020，8，1： | 1 |
| 2 | Molecular Phylogeny of Coral-Reef Sea Cucumbers (Holothuriidae: Aspidochirotida) Based on 16S Mitochondrial Ribosomal DNA Sequence显示文摘 | Alexander M. Kerr Daniel A. Janies Ronald M. Clouse Yves Samyn Jeni Kuszak Junhyong Kim | 2005 | Marine Biotechnology2005，，1： | 1 |
| 3 | Whole proteome identification of plant candidate G-protein coupled receptors in Arabidopsis, rice, and poplar: computational prediction and in -vivo protein coupling 显示文摘 | Timothy E Gookin Junhyong Kim and Sarah M Assmann | 2008 | Genome Biology2008，，9： | 1 |
| 4 | Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing显示文摘Dental primary afferent(DPA)neurons and proprioceptive mesencephalic trigeminal nucleus(MTN)neurons,located in the trigeminal ganglion and the brainstem,respectively,are essential for controlling masticatory functions.Despite extensive transcriptomic studies on various somatosensory neurons,there is still a lack of knowledge about the molecular identities of these populations due to technical challenges in their circuit-validated isolation.Here,we employed high-depth single-cell RNA sequencing(scRNA-seq)in combination with retrograde tracing in mice to identify intrinsic transcriptional features of DPA and MTN neurons.Our transcriptome analysis revealed five major types of DPA neurons with cell type-specific gene enrichment,some of which exhibit unique mechano-nociceptive properties capable of transmitting nociception in response to innocuous mechanical stimuli in the teeth.Furthermore,we discovered cellular heterogeneity within MTN neurons that potentially contribute to their responsiveness to mechanical stretch in the masseter muscle spindles.Additionally,DPA and MTN neurons represented sensory compartments with distinct molecular profiles characterized by various ion channels,receptors,neuropeptides,and mechanoreceptors.Together,our study provides new biological insights regarding the highly specialized mechanosensory functions of DPA and MTN neurons in pain and proprioception. | Pa Reum Lee Jihoon Kim Heather Lynn Rossi Sena Chung Seung Yub Han Junhyong Kim Seog Bae Oh | 2023 | International Journal of Oral Science2023，15，3： | 0 |
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