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| 1 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | A method to produce evolving functional connectivity maps during the course of an FMRI experiment using wavelet-based time-varying Granger causality 显示文摘 | Sato J Junior E Takahashi D | 2006 | NeuroImage2006，31，： | 1 |
| 4 | The essential oil of Eucalyptus tereticornis and its constituents, α-and β-pinene, show accelerative properties on rat gastrointestinal transit 显示文摘 | Juca D M Da Silva M T Junior RC Jr | 2011 | Planta Med2011，77，1： | 1 |
| 5 | Late seroma after breast augmentation with silicone prostheses:a case report显示文摘 | Oliveira VM Roveda Junior D Lucas FB | 2007 | Breast J2007，13，： | 1 |
| 6 | Treatment of twin reversed arterial perfusion sequence by septostomy and amniod- rainage : a case report 显示文摘 | Guimaraes FHA Linhares D Junior EA | 2007 | Arch GynecoI Obstet2007，275，6： | 1 |
| 7 | Chsornosond characterization of the bonytongue Arapaima gigas ( Osteoglossiformes: Arapaimidae ) 显示文摘 | MARQUES D K VENERE P C JUNIOR P M G | 2006 | Neotropical Ichthyology2006，4，2： | 1 |
| 8 | QTL mapping for yield components in a tropical maize population using microsatellite markers显示文摘 | SABADIN P K JUNIOR C L D S SOUZA A P D | 2008 | Hereditas2008，145，4： | 1 |
| 9 | Surface characterization of a corroded bronze-leaded alloy in a salt spray cabinet 显示文摘 | Joao Cura D'Ars de Figueiredo Junior Vanessa de Freitas Cunha Lins Vito Modesto De Bellis | 2007 | Applied Surface Science2007，，253： | 1 |
| 10 | Stability, antimicrobial activity, and effect of nisin on the physico - chemical properties of fruit juices 显示文摘 | Junior A A D O Moura T R D Barbosa A A T | 2015 | International Journal of Food Microbiology2015，211，： | 1 |
| 11 | Physiological analysis of leaf senescence of two rice cul- tivars with different yield potential显示文摘 | Falqueto A R Cassol D Magalhes Junior A M ez at | 2009 | J Pesq Agropec Bras2009，44，7： | 1 |
| 12 | Biodegration of biodiesel/diessl blends by Candida viswanathii显示文摘 | Junior J S Mariano A P Angelis D de | | 0，，12： | 1 |
| 13 | Laparoscopic management of hepatic cysts 显示文摘 | Caetano - Junior EM Linhares MM Matos D | 2006 | Surg Lapa- rosc Endosc Percutan Tech2006，16，2： | 1 |
| 14 | SAR, QSAR and docking of anti cancer flavonoids and variants: a review 显示文摘 | Scotti L Bezerra Mendonca Junior F I Magalhaes Moreira D R | 2009 | Curr Top Med Chem2009，12，24： | 1 |
| 15 | Modelling the critical velocity for heterogeneous flow of mineral slurries 显示文摘 | Pinto T C S Junior D M Slatter P T | 2014 | In-ternational Journal of Multiphase Flow2014，65，： | 1 |
| 16 | Comparative study on sigma phase precipitation of three types of stainless steels: austenite, superferritie and duplex 显示文摘 | D M E Villanueva F C P Junior R L Plaut | 2006 | Materials Science and Technology2006，22，9： | 1 |
| 17 | Comparative modeling and QM/MM studies of cysteiue protease mutant of Theobroma cacao 显示文摘 | ANDRADE D V G G ES-NETO A JUNIOR M C | 2012 | Int J Quantum Chem2012，112，9： | 1 |
| 18 | Monoclonal antibodies against Boophilus microplus and their effects on tick reproductive efficiency 显示文摘 | Toro-Ortiz R D Vaz Junior I S Gonzales J C | 1997 | Vet Parasitol1997，69，： | 1 |
| 19 | Ability of corneal bio- mechanical metrics and gnterior segment data in the differentiation of keratoconus and healthy corneas 显示文摘 | Fontes BM Ambr6sio Junior R Jardim D | 2010 | Arq Bras Oftalmol2010，73，4： | 1 |
| 20 | Iridoid glucosides from penstemon nitidus显示文摘 | Teborg D Junior P | 1991 | Planta Med1991，57，2： | 1 |
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