|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Modification mechanism of cerium on the Al-18Si alloy显示文摘在不同扔的状态下面的高级低共熔体的 Al-Si 合金上的稀土元素铈(Ce ) 的效果被光显微镜和量的图象分析学习了。尺寸和在铸造物的主要的硅的数量随 melt 的增加的 Ce 的增加减少,这被发现。好 facetted 形状的从分叉的形状的同时主要的硅变化。尽管在铸造物的最容易溶解的硅上的修正也随 melt 的增加的 Ce 的增加改善,离开主要的硅的最容易溶解的硅上的修正的效果在到主要的硅的最容易溶解的硅结束上是比那更明显的。修正机制借助于扫描详细被分析电子显微镜与精力装备了 X 光检查和热力学分析的散分析,它在反应和反应平衡的标准吉布斯精力在变化上包括了分析。 | ZHANG Henghua DUAN Haili SHAO Guangjie XU Luoping YIN Junlin YAN Biao | 2006 | Rare Metals2006，25，1： | 23 |
| 2 | Mechanism for the formation and microphysical characteristics of submicron aerosol during heavy haze pollution episode in the Yangtze River Delta, China显示文摘 | Honglei Wang Junlin An Lijuan Shen Bin Zhu Chen Pan Zirui Liu Xiaohui Liu Qing Duan Xuan Liu Yuesi Wang | 2014 | Science of the Total Environment2014，，： | 2 |
| 3 | Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery显示文摘Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue. | Zhongyin Chen Tao Liao Lihui Wan Ying Kuang Chang Liu Junlin Duan Xiangyu Xu Ziqiang Xu Bingbing Jiang Cao Li | 2021 | Nano Research2021，14，11： | 1 |
| 4 | Investigation of the feasibility of NRAV as a biomarker for hepatocellular carcinoma显示文摘The long non-coding RNA,Negative Regulator of Antiviral Response(NRAV)has been identified as a participant in both respiratory virus replication and immune checkpoints,however,its involvement in pan-cancer immune regulation and prognosis,particularly those of hepatocellular carcinoma(HCC),remains unclear.To address this knowledge gap,we analyzed expression profiles obtained from The Cancer Genome Atlas(TCGA)database,comparing normal and malignant tumor tissues.We found that NRAV expression is significantly upregulated in tumor tissues compared to adjacent nontumor tissues.Kaplan-Meier(K-M)analysis revealed the prognostic power of NRAV,wherein overexpression was significantly linked to reduced overall survival in a diverse range of tumor patients.Furthermore,noteworthy associations were observed between NRAV,immune checkpoints,immune cell infiltration,genes related to autophagy,epithelial-mesenchymal transition(EMT),pyroptosis,tumor mutational burden(TMB),and microsatellite instability(MSI)across different cancer types,including HCC.Moreover,NRAV upregulation expression was associated with multiple pathological stages by clinical observations.Furthermore,our investigation revealed a substantial elevation in the expression of NRAV in both HCC tumor tissues and cells compared to normal tissues and cells.The inhibition of NRAV resulted in the inhibition of cell proliferation,migration,and invasion in HCC cells,while also influencing the expression of CD274(PD-L1)and CD44,along with various biomarkers associated with EMT,autophagy,and pyroptosis.The aforementioned results propose NRAV as a promising prognostic biomarker for HCC. | JUN LIU WENLI LI RUYUE LU JIAQING XU CHUNHUI JIANG JUNLIN DUAN LINGZHI ZHANG GUANFU WANG JIAXI CHEN | 2024 | Oncology Research2024，32，4： | 0 |
| 5 | Multi-omics analysis reveals the molecular regulatory network underlying the prevention of Lactiplantibacillus plantarum against LPS-induced salpingitis in laying hens显示文摘Background Salpingitis is one of the common diseases in laying hen production, which greatly decreases the economic outcome of laying hen farming. Lactiplantibacillus plantarum was effective in preventing local or systemic inflammation, however rare studies were reported on its prevention against salpingitis. This study aimed to investigate the preventive molecular regulatory network of microencapsulated Lactiplantibacillus plantarum(MLP) against salpingitis through multi-omics analysis, including microbiome, transcriptome and metabolome analyses.Results The results revealed that supplementation of MLP in diet significantly alleviated the inflammation and atrophy of uterus caused by lipopolysaccharide(LPS) in hens(P < 0.05). The concentrations of plasma IL-2 and IL-10 in hens of MLP-LPS group were higher than those in hens of LPS-stimulation group(CN-LPS group)(P < 0.05). The expression levels of TLR2, MYD88, NF-κB, COX2, and TNF-α were significantly decreased in the hens fed diet supplemented with MLP and suffered with LPS stimulation(MLP-LPS group) compared with those in the hens of CN-LPS group(P < 0.05). Differentially expressed genes(DEGs) induced by MLP were involved in inflammation, reproduction, and calcium ion transport. At the genus level, the MLP supplementation significantly increased the abundance of Phascolarctobacterium, whereas decreased the abundance of Candidatus_Saccharimonas in LPS challenged hens(P < 0.05). The metabolites altered by dietary supplementation with MLP were mainly involved in galactose, uronic acid, histidine, pyruvate and primary bile acid metabolism. Dietary supplementation with MLP inversely regulates LPSinduced differential metabolites such as Lyso PA(24:0/0:0)(P < 0.05).Conclusions In summary, dietary supplementation with microencapsulated Lactiplantibacillus plantarum prevented salpingitis by modulating the abundances of Candidatus_Saccharimonas, Phascolarctobacterium, Ruminococcus_torques_group and Eubacterium_hallii_group while downregulating the levels of plasma metabolites, p-tolyl sulfate, o-cresol and N-acetylhistamine and upregulating S-lactoylglutathione, simultaneously increasing the expressions of CPNE4, CNTN3 and ACAN genes in the uterus, and ultimately inhibiting oviducal inflammation. | Dan Song Aike Li Bingxu Chen Jia Feng Tao Duan Junlin Cheng Lixian Chen Weiwei Wang Yuna Min | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 6 | Erratum to: Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery显示文摘Erratum to Nano Research 2021,14(11):4264-4273 https://doi.org/10.1007/s12274-021-3624-4 The first two authors part of this article was unfortunately misrepresented on the first page and in the ESM. | Zhongyin Chen Tao Liao Lihui Wan Ying Kuang Chang Liu Junlin Duan Xiangyu Xu Ziqiang Xu Bingbing Jiang Cao Li | 2021 | Nano Research2021，14，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员