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| 1 | Applying a new method for direct collection, volume quantification and determination of N_2 emission from water显示文摘The emission of N2 is important to remove excess N from lakes, ponds, and wetlands. To investigate the gas emission from water, Gao et al.(2013) developed a new method using a bubble trap device to collect gas samples from waters. However, the determination accuracy of sampling volume and gas component concentration was still debatable. In this study, the method was optimized for in situ sampling, accurate volume measurement and direct injection to a gas chromatograph for the analysis of N2 and other gases. By the optimized new method, the recovery rate for N2 was 100.28% on average; the mean coefficient of determination(R2) was 0.9997; the limit of detection was 0.02%. We further assessed the effects of the new method, bottle full of water, vs. vacuum bag and vacuum vial methods, on variations of N2 concentration as influenced by sample storage times of 1,2, 3, 5, and 7 days at constant temperature of 15°C, using indices of averaged relative peak area(%) in comparison with the averaged relative peak area of each method at 0 day.The indices of the bottle full of water method were the lowest(99.5%–108.5%) compared to the indices of vacuum bag and vacuum vial methods(119%–217%). Meanwhile, the gas chromatograph determination of other gas components(O2, CH4, and N2O) was also accurate. The new method was an alternative way to investigate N2 released from various kinds of aquatic ecosystems. | Xinhong Liu Yan Gao Honglian Wang Junyao Guo Shaohua Yan | 2015 | Journal of Environmental Sciences2015，27，1： | 3 |
| 2 | Tetrahedral framework nucleic acids promote the biological functions and related mechanism of synovium-derived mesenchymal stem cells and show improved articular cartilage regeneration activity in situ显示文摘Many recent studies have shown that joint-resident mesenchymal stem cells(MSCs)play a vital role in articular cartilage(AC)in situ regeneration.Specifically,synovium-derived MSCs(SMSCs),which have strong chondrogenic differentiation potential,may be the main driver of cartilage repair.However,both the insufficient number of MSCs and the lack of an ideal regenerative microenvironment in the defect area will seriously affect the regeneration of AC.Tetrahedral framework nucleic acids(tFNAs),notable novel nanomaterials,are considered prospective biological regulators in biomedical engineering.Here,we aimed to explore whether tFNAs have positive effects on AC in situ regeneration and to investigate the related mechanism.The results of in vitro experiments showed that the proliferation and migration of SMSCs were significantly enhanced by tFNAs.In addition,tFNAs,which were added to chondrogenic induction medium,were shown to promote the chondrogenic capacity of SMSCs by increasing the phosphorylation of Smad2/3.In animal models,the injection of tFNAs improved the therapeutic outcome of cartilage defects compared with that of the control treatments without tFNAs.In conclusion,this is the first report to demonstrate that tFNAs can promote the chondrogenic differentiation of SMSCs in vitro and enhance AC regeneration in vivo,indicating that tFNAs may become a promising therapeutic for AC regeneration. | Liwei Fu Pinxue Li Junyao Zhu Zhiyao Liao Cangjian Gao Hao Li Zhen Yang Tianyuan Zhao Wei Chen Yu Peng Fuyang Cao Chao Ning Xiang Sui Quanyi Guo Yunfeng Lin Shuyun Liu | 2022 | Bioactive Materials2022，7，3： | 1 |
| 3 | Estimation of N 2 and N 2 O ebullition from eutrophic water using an improved bubble trap device显示文摘 | Yan Gao Xinhong Liu Neng Yi Yan Wang Junyao Guo Zhenhua Zhang Shaohua Yan | 2013 | Ecological Engineering2013，，： | 1 |
| 4 | Nitrogen removal from Lake Caohai, a typical ultra-eutrophic lake in China with large scale confined growth of Eichhornia crassipes显示文摘 | Zhi Wang Zhiyong Zhang Yingying Zhang Junqian Zhang Shaohua Yan Junyao Guo | 2013 | Chemosphere2013，92，2： | 1 |
| 5 | Monolayer molecular crystals for low-energy consumption optical synaptic transistors显示文摘Artificial synaptic devices hold great potential in building neuromorphic computers.Due to the unique morphological features,twodimensional organic semiconductors at the monolayer limit show interesting properties when acting as the active layers for organic field-effect transistors.Here,organic synaptic transistors are prepared with 1,4-bis((5’-hexyl-2,2’-bithiophen-5-yl)ethyl)benzene(HTEB)monolayer molecular crystals.Functions similar to biological synapses,including excitatory postsynaptic current(EPSC),pair-pulse facilitation,and short/long-term memory,have been realized.The synaptic device achieves the minimum power consumption of 4.29 fJ at low drain voltage of−0.01 V.Moreover,the HTEB synaptic device exhibits excellent long-term memory with 109 s EPSC estimated retention time.Brain-like functions such as dynamic learning-forgetting process and visual noise reduction are demonstrated by nine devices.The unique morphological features of the monolayer molecular semiconductors help to reveal the device working mechanism,and the synaptic behaviors of the devices can be attributed to oxygen induced energy level.This work shows the potential of artificial neuroelectronic devices based on organic monolayer molecular crystals. | Zhekun Hua Ben Yang Junyao Zhang Dandan Hao Pu Guo Jie Liu Lang Jiang Jia Huang | 2022 | Nano Research2022，15，8： | 0 |
| 6 | Air-stable synaptic devices based on bismuth triiodide and carbon nanotubes显示文摘Artificial synaptic devices with the functions of emulating important biological synaptic behaviors are playing an increasingly important role in the development of neuromorphic computing systems.Single-walled carbon nanotubes(SWCNTs)with excellent electrical properties and high stability have been studied as active materials for synaptic devices.However,the performance of optical synaptic devices(OSDs)based on pure SWCNTs is limited by the weak light absorption property.Herein,bismuth triiodide(BiI_(3)),an environmentally stable and friendly optoelectronic material,is firstly combined with SWCNTs to fabricate OSDs with decent properties of perceiving and memorizing optical information.The OSDs can exhibit typical synaptic behaviors including excitatory postsynaptic current,paired-pulse facilitation,and short/long-term memory.Distinctively,the photoresponse of the OSD is independent of pulse light wavelength in the range of 365 to 650 nm,different from most of the previously reported OSDs,which usually have wavelength-dependent photo-response.Temperature-dependent photo-response behaviors of the devices are investigated.Importantly,the OSD without encapsulation holds good excitatory post-synaptic current(EPSC)behavior after being stored in the ambient environment for 170 days,indicating reliable environmental stability.Furthermore,an OSD array with nine synaptic devices is employed to mimic the human visual perception and memory functions.These results suggest the feasibility of BiI3/SWCNTs-based OSDs for the simulation of human visual memory. | Dandan Hao Junyao Zhang Li Li Ben Yang Pu Guo Shiqi Zhang Jia Huang | 2022 | Nano Research2022，15，6： | 0 |
| 7 | The m^(6)A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B显示文摘Inherited retinal dystrophies (IRDs) are major causes of visual impairment and irreversible blindness worldwide, while the precise molecular and genetic mechanisms are still elusive. N6-methyladenosine (m^(6)A) modification is the most prevalent internal modification in eukaryotic mRNA. YTH domain containing 2 (YTHDC2), an m^(6)A reader protein, has recently been identified as a key player in germline development and human cancer. However, its contribution to retinal function remains unknown. Here, we explore the role of YTHDC2 in the visual function of retinal rod photoreceptors by generating rod-specific Ythdc2 knockout mice. Results show that Ythdc2 deficiency in rods causes diminished scotopic ERG responses and progressive retinal degeneration. Multi-omics analysis further identifies Ppef2 and Pde6b as the potential targets of YTHDC2 in the retina. Specifically, via its YTH domain, YTHDC2 recognizes and binds m^(6)A-modified Ppef2 mRNA at the coding sequence and Pde6b mRNA at the 5′-UTR, resulting in enhanced translation efficiency without affecting mRNA levels. Compromised translation efficiency of Ppef2 and Pde6b after YTHDC2 depletion ultimately leads to decreased protein levels in the retina, impaired retinal function, and progressive rod death. Collectively, our finding highlights the importance of YTHDC2 in visual function and photoreceptor survival, which provides an unreported elucidation of IRD pathogenesis via epitranscriptomics. | Yeming Yang Xiaoyan Jiang Junyao Chen Lu Liu Guo Liu Kuanxiang Sun Wenjing Liu Xianjun Zhu Qiuyue Guan | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 8 | Bioinspired organic optoelectronic synaptic transistors based on cellulose nanopaper and natural chlorophyll-a for neuromorphic systems显示文摘Inspired by human brains,optoelectronic synapses are expected as one of significant steps for constructing neuromorphic systems.In addition,intensive attention has been paid to biodegradable and biocompatible materials for developing green electronics.In this regard,environmentally friendly organic optoelectronic synaptic transistors based on wood-derived cellulose nanopaper(WCN)as dielectric/substrate and nature chlorophyll-a as photoactive material are demonstrated.Both WCN and chlorophyll-a are biocompatible and biodegradable materials from natural organisms.Versatile synaptic behaviors have been well mimicked by the modulation of both electrical and optical signals.More significantly,optical wireless communication is experimentally emulated and the information processing capability is also verified in pattern recognition simulation.Furthermore,the flexible synaptic transistors exhibit no apparent synaptic performance degradation even when the bending radius is reduced to 1 mm.Our work may develop a promising approach for the development of green and flexible electronics in neuromorphic visual systems. | Junyao Zhang Dapeng Liu Qianqian Shi Ben Yang Pu Guo Lu Fang Shilei Dai Lize Xiong Jia Huang | 2022 | npj Flexible Electronics2022，6，1： | 0 |
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