|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neglected tropical diseases in the People’s Republic of China: progress towards elimination显示文摘Since the founding of the People's Republic of China in 1949,considerable progress has been made in the control and elimination of the country's initial set of 11 neglected tropical diseases.Indeed,elimination as a public health problem has been declared for lymphatic filariasis in 2007 and for trachoma in 2015.The remaining numbers of people affected by soil-transmitted helminth infection,clonorchiasis,taeniasis,and echinococcosis in 2015 were 29.1 million,6.0 million,366200,and 166100,respectively.In 2017,after more than 60 years of uninterrupted,multifaceted schistosomiasis control,has seen the number of cases dwindling from more than 10 million to 37600.Meanwhile,about 6000 dengue cases are reported,while the incidence of leishmaniasis,leprosy,and rabies are down at 600 or fewer per year.Sustained social and economic development,going hand-in-hand with improvement of water,sanitation,and hygiene provide the foundation for continued progress,while rigorous surveillance and specific public health responses will consolidate achievements and shape the elimination agenda.Targets for poverty elimination and strategic plans and intervention packages post-2020 are important opportunities for further control and elimination,when remaining challenges call for sustainable efforts. | Men-Bao Qian Jin Chen Robert Bergquist Zhong-Jie Li Shi-Zhu Li Ning Xiao Jurg Utzinger Xiao-Nong Zhou | 2019 | Infectious Diseases of Poverty2019，8，5： | 23 |
| 2 | Changes in reproductive investment with altitude in an alpine plant显示文摘Aims In perennial species,the allocation of resources to reproduction results in a reduction of allocation to vegetative growth and,therefore,impacts future reproductive success.As a consequence,variation in this trade-off is among the most important driving forces in the life-history evolution of perennial plants and can lead to locally adapted genotypes.In addition to genetic variation,phenotypic plasticity might also contribute to local adaptation of plants to local conditions by mediating changes in reproductive allocation.Knowledge on the importance of genetic and environmental effects on the tradeoff between reproduction and vegetative growth is therefore essential to understand how plants may respond to environmental changes.Methods We conducted a transplant experiment along an altitudinal gradient from 425to1921 min the frontrange of the Western Alps of Switzerland to assess the influence of both altitudinal origin of populations and altitude of growing site on growth,reproductive investment and local adaptation in Poa alpina.Important findings In our study,the investment in reproduction increased with plant size.Plant growth and the relative importance of reproductive investment decreased in populations originating from higher altitudes compared to populations originating from lower altitudes.The changes in reproductive investment were mainly explained by differences in plant size.In contrast to genetic effects,phenotypic plasticity of all traits measured was low and not related to altitude.As a result,the population from the lowest altitude of origin performed best at all sites.Our results indicate that in P.alpina genetic differences in growth and reproductive investment are related to local conditions affecting growth,i.e.interspecific competition and soil moisture content. | Yann Hautier Christophe F.Randin Jurg Stocklin Antoine Guisan | 2009 | Journal of Plant Ecology2009，2，3： | 17 |
| 3 | The Inflammasomes显示文摘 | Kate Schroder Jurg Tschopp | 2010 | Cell2010，，6： | 10 |
| 4 | 中国大陆福寿螺种群遗传学研究显示文摘目的通过遗传标记分析中国大陆福寿螺种群结构特点,为研究其侵入途径和扩散模式提供基础。方法利用CO I基因扩增引物对中国大陆60个采集点的581个福寿螺标本进行遗传学分析。利用DnaSP 5.10.01进行单倍型多样性和核酸多样性分析,并通过Network 4.2.0.1进行单倍型网络分析。综合GenBank上可利用的福寿螺单倍型和本研究获得的单倍型进行进化关系分析,了解中国大陆福寿螺的进化地位。结果共获得556条有效序列,分属25个单倍型,其中6个单倍型频率较高,占整个样本的96.0%。进化分析表明我国存在Pom cea canaliculata和P.insula-rum2个种。P.insularum单倍型与国外报告类型存在较大差异。结论中国大陆福寿螺种群结构复杂,可能有多种来源和扩散模式。 | 吕山 张仪 刘和香 胡铃 柳伟 刘琴 李石柱 胡薇 Jurg Utzinger 周晓农 | 2011 | 中国血吸虫病防治杂志2011，23，2： | 10 |
| 5 | 葡萄糖-果糖比对发酵停滞的影响及其预防、重启策略显示文摘通过分析发酵停滞的葡萄酒中残糖含量发现,绝大多数情况下残糖以果糖为主,即有极低的葡萄糖-果糖比。在重启发酵停滞的葡萄酒时,最好先从中分离除去死酵母,然后重新接种活性酵母,并将温度升高至22℃以上。酵母可选择酿酒酵母(Saccharmyces cerevisiae)或贝酵母(Scaaharomyces bayanus)。 | 陈莹 屈慧鸽 JURG GAFBER | 2010 | 中外葡萄与葡萄酒2010，，3： | 5 |
| 6 | Comparison of cauliflower-insect-fungus interactions and pesticides for cabbage root fly control显示文摘 | Jaka Razinger Metka Zerjav Meta Zemljic-Urbancic Spela Modic Matthias Lutz Hans-Josef Schroers Jurg Grunder Simon Fellous Gregor Urek | 2017 | Insect Science2017，24，6： | 2 |
| 7 | 蒿甲醚对曼氏血吸虫的作用 :剂量与效应的关系和虫的形态学和组织病理学的变化(英文)显示文摘目的 应用感染曼氏血吸虫 (利比里亚株 )的小鼠观察蒿甲醚单剂量与效应的关系 ,虫体肝移及蒿甲醚所引起的虫的形态学和组织病理学变化。 方法 感染 2 1d童虫的小鼠一次口服蒿甲醚 12 .5mg/kg至 60 0mg/kg不同剂量 ,治后 2 8d剖检观察各组虫数。感染 46d或 70d成虫的小鼠一次口服蒿甲醚 40 0mg/kg后 8~ 14d ,观察虫体肝移及其形态和组织病理学变化。 结果 蒿甲醚对 2 1d童虫的最低有效剂量为 2 0 0mg/kg ,减虫率为 81%。用蒿甲醚治疗后 8h成虫开始肝移 ,3~ 7d全部肝移 ,14d有 3 1%的虫返回肠系膜静脉。成虫虫体萎缩 ,咽部扩大 ,肠管膨胀及其色素减少。雌虫局部体表受损 ,白细胞附着 ,卵巢及卵黄腺变性退化 ,以及雄虫睾丸萎缩等。在肝内的虫体被嗜酸粒细胞为主的炎细胞包围和浸润。 结论 蒿甲醚对小鼠曼氏血吸虫 2 1d童虫的最低有效剂量为 2 0 0mg/kg ,可引起曼氏血吸虫成虫萎缩、退化或死亡。在肝内受损的虫体主要是被嗜酸粒细胞包围和侵袭所致。 | 肖树华 郭俭 Jacques Chollet 吴嘉彤 Marcel Tanner Jurg Utzinger | 2004 | 中国寄生虫学与寄生虫病杂志2004，22，3： | 2 |
| 8 | 6英寸超高压直流输电用晶闸管显示文摘正如我们所看到的,随着中国社会的快速发展,大电力超远距离传输的需求迅速增长,用于高压直流输电工业的晶闸管的功率要求也越来越大。为此目的,ABB开发了一种6英寸、8.5 kV/4000A的晶闸管,该晶闸管具有良好的阻断特性、高dv/dt能力、以及所需的擎住灵敏性。可靠性研究表明,该晶闸管能够很好的经受住80℃、5000次的负载循环,并在90℃、1000小时的交流阻断中保持恒定的漏电流。 | Virgiliu Botan Jurg Waldmeyer Magnus Kunow Kranthi Akurati 张斌 | 2010 | 电力电子2010，，5： | 2 |
| 9 | The impact of pastoralist mobility on tuberculosis control in Ethiopia:a systematic review and meta-synthesis显示文摘Background:Directly observed treatment,short-course(DOTS)is the current mainstay to control tuberculosis(TB)worldwide.Context-specific adaptations of DOTS have impending implications in the fight against TB.In Ethiopia,there is a national TB control programme with the goal to eliminate TB,but uneven distribution across lifestyle gradients remains a challenge.Notably,the mobile pastoralist communities in the country are disproportionately left uncovered.The aim of this study was to summarize the evidence base from published literature to guide TB control strategy for mobile pastoralist communities in Ethiopia.Main text:We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines and systematically reviewed articles in seven electronic databases:Excerptra Medical Database,African Journal Online,PubMed,Google Scholar,Centre for Agriculture and Bioscience International Direct,Cochrane Library and Web of Science.The databases were searched from inception to December 31,2018,with no language restriction.We screened 692 items of which 19 met our inclusion criteria.Using a meta-ethnographic method,we identified six themes:(i)pastoralism in Ethiopia;(ii)pastoralists’livelihood profile;(iii)pastoralists’service utilisation;(iv)pastoralists’knowledge and awareness on TB control services;(v)challenges of TB control in pastoral settings;and(vi)equity disparities affecting pastoralists.Our interpretation triangulates the results across all included studies and shows that TB control activities observed in pastoralist regions of Ethiopia are far fewer than elsewhere in the country.Conclusions:This systematic review and meta-synthesis shows that TB control in Ethiopia does not align well with the pastoralist lifestyle.Inaccessibility and lack of acceptability of TB care are the key bottlenecks to pastoralist TB service provision.Targeting these two parameters holds promise to enhance effectiveness of an intervention. | Faisal Nooh Lisa Crump Abdiwahab Hashi Rea Tschopp Esther Schelling Klaus Reither Jan Hattendorf Seid M.Ali Brigit Obrist Jurg Utzinger Jakob Zinsstag | 2019 | Infectious Diseases of Poverty2019，8，5： | 2 |
| 10 | The genetic variation of Angiostrongylus cantonensis in the People’s Republic of China显示文摘Background:The People’s Republic of China(P.R.China)is the presumptive home range of the rat lungworm Angiostrongylus cantonensis,a major aetiological agent of human eosinophilic meningitis.We present a study of the genetic variation of A.cantonensis in P.R.China.Our aim was to deepen the current knowledge pertaining to its origin and global spread from a molecular perspective.Methods:Adult A.cantonensis were collected in the frame of a national survey and identified based on morphological criteria.Polymerase chain reaction(PCR)was employed to amplify the target DNA sequences(cytochrome c oxidase subunit I(cox1),nicotinamide adenine dinucleotide dehydrogenase subunit 1(nad1)and internal transcribed spacer(ITS)).The PCR product of cox1 was directly submitted to sequencing,while clone sequencing was used for nad1 and ITS.The identity of the samples was verified by comparing the sequences to those of accepted A.cantonensis specimens.The specific composition of substitutions in each gene was analysed,and the genotypes were compared based on the complete cox1,nad1 and ITS genes.Results:We characterised the complete mitochondrial genes cox1 and nad1 of 130 specimens and obtained 357 nuclear sequences containing two complete ITS(ITS1 and ITS2)and 5.8S rRNA of the same samples.All specimens were genetically confirmed as A.cantonensis.Two major groups(i.e.I and II)were identified according to the phylogeny of cox1 sequences.Group I could be further categorised into six distinct clades.Almost half of the specimens(47.7%)belong to the clade Ia and 22.3%to the group II.The former was widely distributed across the study region.A variable number of repeat units in three microsatellites was observed,resulting in considerable length variation in ITS.Intragenomic variation of ITS sequences was found in a large proportion of the samples.Genotyping showed a striking difference between mitochondrial DNA and ITS.Conclusions:Our results demonstrate that A.cantonensis is the only rat lungworm species in P.R.China and shows high genetic diversity.Results of diversity and genotyping of A.cantonensis can be impacted by the sequencing strategy and biomarker.Although ITS may be a valuable marker for interspecific identification,it is not suitable for studying the intraspecific variation of A.cantonensis due to its high intragenomic variation and current challenges for direct sequencing. | Shan Lv Yi Zhang Peter Steinmann Jurg Utzinger Xiao-Nong Zhou | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 11 | Combination Chemotherapy of Schistosomiasis in Laboratory Studies andClinical Trials显示文摘 | Jennifer K Xiao SH | 2003 | Antimicrob Agents Chemother2003，47，5： | 1 |
| 12 | Study of Factors Affecting Simultaneous Nitrification and Denitrification (SND)显示文摘 | Klangduen Pochana Jurg Keller | 1999 | Wat Sci Tech1999，39，6： | 1 |
| 13 | Simultaneous nitrificationand denitrification in bench scale sequencing batch reactor显示文摘 | Elisabeth V Munch Paul Lant Jurg Keller | 1996 | WaterRes1996，30，2： | 1 |
| 14 | Quantitative competitive (QC) PCR for quantication of porcine DNA显示文摘 | Christian Wolf Jurg Luthy | 2001 | Meat Science2001，57，： | 1 |
| 15 | Study of factors affecting for simuhaneous nitrification and denitrification (SND) 显示文摘 | Klangduen Pochana Jurg Keller | 1999 | Water Science and Technology1999，39，6： | 1 |
| 16 | Simultaneous nitrification and denitrification in bench-scale sequencing batch reactors 显示文摘 | Elisabeth V Munch Paul Lant Jurg Keller | 1996 | Water Res1996，30，2： | 1 |
| 17 | Class and subclass-specific pneumococcal antibody levels and response to immunization after bone marrow transplantation显示文摘 | Lortan J E Vellodi J Jurges E S | | 0，，： | 1 |
| 18 | Reptilase- The History and Mode of Action of Hemostyptic Drug from Snake显示文摘 | Jurg Meier & Kurt Stocker | 1992 | Venom Origin1992，7，5： | 1 |
| 19 | Do capital adequacy requirements reduce risks in banking? 显示文摘 | Jurg Blum | 1999 | Journal of Banking & Finance1999，，23： | 1 |
| 20 | Are different measures of self-rated health comparable? An assessment in five Europeaneountries 显示文摘 | Jurges H Avendano M Mackenbaeh JP | 2008 | Eur J Epidemiol2008，23，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员