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| 1 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 2 | Highly dispersed nanosilica-epoxy resins with enhanced mecha- nical properties显示文摘 | CHEN C G JUSTICE R S SCHAEFER D W | 2008 | Polymer2008，49，17： | 1 |
| 3 | Terrestrial remote sensing science and algorithms planned for EOS/MODIS 显示文摘 | Running S W Justice C J Sao mon son V | 1994 | Int J R S1994，15，17： | 1 |
| 4 | The MODIS fire products显示文摘 | Justice C O Giglio L Korontzi S | 2002 | Remote Sensing of Environment2002，83，： | 1 |
| 5 | The MODIS fire products显示文摘 | C.O Justice L Giglio S Korontzi J Owens J.T Morisette D Roy J Descloitres S Alleaume F Petitcolin Y Kaufman | 2002 | Remote Sensing of Environment2002，，1： | 1 |
| 6 | “全球化背景下高等教育特色发展模式论坛”综述显示文摘'全球化背景下高等教育特色发展模式论坛'围绕着高等教育的发展特色,高等教育如何与社会接轨、如何为社会服务,高等教育的培养目标、教育方法等热点问题进行了充分的交流。强调信息化时代对高等教育提出了新的挑战,教育要具有适应性和弹性;强调高等教育必须服务于社会需求;强调高等教育必须注重内涵建设;引入了公安教育的新视角——私人保安教育与培训,为我院公安教育的深入研究和发展提供了新的思路、拓展了新的领域。 | Dean’s Office of Liaoning Administrators College of Police and Justice (Liaoning Administrators College of Police and Justice,Shenyang,Liaoning 110161, China) | 2010 | 辽宁公安司法管理干部学院学报2010，，1： | 1 |
| 7 | A global by NDVI dataset for cli- mate studies derived fi'om the GIMMS continental NDVI data显示文摘 | Los S O Justice C O Tucker C J | 1994 | International Journal of Remote Sensing1994，15，17： | 1 |
| 8 | An enhanced contextual fire detection algorithm for MODIS显示文摘 | Giglio L Descloitres J S Justice C O | 2003 | Remote Sensing of Environ- ment2003，87，： | 1 |
| 9 | Synthesis, characterization, and adsorption properties of nanocrystalline ZSM-5 显示文摘 | SONG W JUSTICE R E JONES C A GRASSIAN V H LARSEN S C | 2004 | Langmuir2004，20，19： | 1 |
| 10 | The MODIS Fire Products显示文摘 | Justice C O Giglio L Korontzi S | 2002 | Remote Sensing of Environment2002，83，： | 1 |
| 11 | A glob- al 1° by 1° NDVI dataset for climate studies de- rived from the GIMMS continental NDVI data显示文摘 | Los S O JUSTICE C O TUCKER C J | 1994 | International Journal of Remote Sensing1994，15，17： | 1 |
| 12 | Monitoring the grasslands of the Sahe| 1984 - 1985 显示文摘 | Tucker C J Justice C O Prince S D | 1986 | International Journal of Remote Sens- ing1986，7，： | 1 |
| 13 | Effect of glucocorticoids and oestrogen on interleukin-6 production by human thyrocytes from patients with Graves'disease and toxic multinodular goitre and from HTori 3 cells显示文摘 | Jones T H Kennedy R L Justice S K | 1997 | Eur J Endocrinol1997，13，7： | 1 |
| 14 | Terrestrial remote sensing science and algorithms planned for EOS/MODIS显示文摘 | Running S W Justic C Salomonson V | 1994 | Remote Sens Environ1994，15，17： | 1 |
| 15 | Bacterial cell divi- sion显示文摘 | ROTHFIELD L JUSTICE S GARCIA L J | 1999 | Annu Rev Genet1999，33，： | 1 |
| 16 | How nano are nanoeomposites 显示文摘 | Schaefer D W Justice R S | 2007 | Macromolecules2007，40，24： | 1 |
| 17 | Virulent combinations of adhesion and toxin genes in natural populations of Staphylococcus aureus 显示文摘 | Peacock S J Moore CE Justice A | 2002 | Infect Immun2002，70，9： | 1 |
| 18 | A global 1 degree by 1 degree NDVI data set for climate studies derived from the GIMMS continental NDVI 显示文摘 | Los S Justice C Tucker C | 1994 | International Journal of Remote Sensing1994，15，17： | 1 |
| 19 | Synthesis, characterization, and adsorption properties of nanocrystaUine ZSM-5显示文摘 | SONG W JUSTICE R E JONES C A GRASSIAN V H LARSEN S C | 2004 | Langmuir2004，20，19： | 1 |
| 20 | How nano m'e nanocomposites 显示文摘 | Schaeffer D W Justice R S | 2007 | Macromolecules2007，40，24： | 1 |
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