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| 1 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 2 | Workflow automation : overview and research issues 显示文摘 | Stohr Edward A Zhao J L | 2001 | Information Systems Frontiers2001，3，3： | 1 |
| 3 | Insertion mutation at the Cterminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice显示文摘 | Zhao S Edwards J Carroll J | 2006 | Neuroscience2006，140，1： | 1 |
| 4 | Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice 显示文摘 | Zhao S Edwards J Carroll J | 2006 | Neurosci2006，140，1： | 1 |
| 5 | High-resolution stalagmite ~lSO records of Asian monsoon changes in central and southern China spanning the MIS 3/2 transition显示文摘 | Zhao K Wang Y J Edwards R L Cheng H Liu D B | 2010 | Earth Planet Sci Lett2010，298，1： | 1 |
| 6 | Downsizing, ideology and contracts: a Chinese perspective 显示文摘 | Zhao J Rust K G McKinley W Edwards J C | 2010 | Chinese Management Studies2010，4，2： | 1 |
| 7 | The gennme of the mesopolyploid crop species Brassica rapa 显示文摘 | Wang X Wang H Wang J Sun R Wu J Liu S Bai Y Mun JH Bancroft I Cheng F Huang S Li X Hua W Wang J Wang X Freeling M Pires JC Paterson AH Chalhoub B Wang B Hayward A Sharpe AG Park BS Weisshaar B Liu B Li B Liu B Tong C Song C Duran C Peng C Geng C Koh C Lin C Edwards D Mu D Shen D Soumpourou E Li F Fraser F Conant G Lassalle G King G J Bonnema G Tang H Wang H Belcram H Zhou H Hirakawa H Abe I-I Guo H Wang H Jin H Parkin IA Batley J Kim JS Just J l i J Xu J Deng J Kim JA Li J Yu J Meng J Wang J Min J Poulain J Wang J Hatakeyama K Wu K Wang L Fang L Trick M Links MG Zhao M Jin M Ramchiary N Drou N Berkman PJ Cai Q Huang Q Li R Tabata S Cheng S Zhang S Zhang S Huang S Sato S Sun S Kwon SJ Choi SR Lee TH Fan W Zhao X Tan X Xu X Wang Y Qiu Y Yin Y l i Y Du Y Liao Y Lira Y Narusaka Y Wang Y Wang Z Li Z Wang Z Xiong Z Zhang Z Brassica rapa Genome Sequencing Project Consortium | 2011 | Nature Genetics2011，43，10： | 1 |
| 8 | A high-resolved record of the Asian summer Monsoon from Dongge Cave, China form the past 1200 years显示文摘 | ZHAO K WANG Y J EDWARD R L CHENG H LIU D B KONG X G | 2015 | Quaternary Science Reviews2015，122，： | 1 |
| 9 | A high-resolution stalagmite record of the Holocene East Asian monsoon from Mt Shennogjia, central China显示文摘 | DONG J G WANG Y J CHENG H HARDT B EDWARDS R 1 KONG X ZHAO K | 2010 | The Holocene2010，20，2： | 1 |
| 10 | The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes 显示文摘 | Liu S Liu Y Yang X Tong C Edwards D Parkin I A P Zhao M Ma J Yu J Huang S Wang X Wang J Lu K Fang Z Bancroft I Yang T J Hu Q Wang X Yue Z Li H Yang L Wu J Zhou Q Wang W King G J Chris Pires J Lu C Wu Z Sampath P Wang Z Guo H Pan S Yang L Min J Zhang D Jin D Li W Belcram H Tu J Guan M Qi C Du D Li J Jiang L Batley J Sharpe A G Park B S Ruperao P Cheng F Espinosa Waminal N Huang Y Dong C Wang L Li J Hu Z Zhuang M Huang Y Huang J Shi J Mei D Liu J Lee T Wang J Jin H Li Z Li X Zhang J Xiao L Zhou Y Liu Z Liu X Qin R Tang X Liu W Wang Y Zhang Y Lee J Kim H H Denoeud F Xu X Liang X Hua W Wang X Wang J Chalhoub B Paterson A H | 2014 | Nature Communications2014，5，： | 1 |
| 11 | High-resolution stalagmite 880 records of Asian monsoon changes in central and southern China spanning the MIS 3/2 transition显示文摘 | Zhao K Wang Y J Edwards R L Cheng H Liu D B | 2010 | Earth Planet Sci Lett2010，298，1： | 1 |
| 12 | Insertion mutation at the C-terminus of the serotonin transporter disrupts brain sero- tonin function and emotion-related behaviors in mice显示文摘 | Zhao S Edwards J Carroll J | 2006 | Neuroscience2006，140，1： | 1 |
| 13 | Down- sizing, ideology and contracts : A Chinese perspective 显示文摘 | Zhao J Rust K G McKinley W Edwards J C | 2010 | Chinese Management Studies2010，4，2： | 1 |
| 14 | 细胞内氯化物通道4异常表达可导致肺动脉高压患者内皮功能紊乱显示文摘细胞内氯化物通道4(chloride intracellular chan-nel4,CLIC4)在肺动脉高压(pulmonaryarterialhy-pertension,PAH)患者重塑的肺血管内皮和丛状病灶中高度表达。CLIC4通过形成内皮管腔调节血管生成,其异常表达可导致PAH患者肺血管病理性改变。方法和结果:CLIC4蛋白在特发性PAH(idiopathicPAH,IPAH)患者血浆和从血液中分离的内皮细胞, | 刘莉 叶鹏 Wojciak-Stothard B AbdulSalam VB Lao KH Tsang H Irwin DC Lisk C Loomis Z Stenmark KR Edwards JC Yuspa SH Howard LS Edwards RJ Rhodes CJ Gibbs JS Wharton J Zhao L Wilkins MR | 2014 | 中华高血压杂志2014，22，5： | 0 |
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