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| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Socio-economic and Environmental Implications of the Hydroelectric Projects in Uttarakhand Himalaya, India显示文摘This paper deals with detailed analysis of the fiasco created by the Tehri High Dam in Uttarakhand, India, particularly in terms of resettlement and rehabilitation of the local inhabitants. Aspects pertaining to the environmental issues are also discussed. Currently, the river valleys in Uttarakhand state of India are the targets of increasing hydroelectric projects. Virtually all rivers are being exploited for generating environmental friendly power. Having being learned the hard lesson from Tehri Dam, it has been decided to opt for such schemes in which comparatively little submergence and tempering with the fragile eco-systems is involved.However, our observations suggest that even in such schemes if due care is not taken they may turn out to be a failure. | Naresh Rana S. P. Sati Y.P. Sundriyal Madan Mohan Doval Navin Juyal | 2007 | Journal of Mountain Science2007，4，4： | 3 |
| 3 | Elevation, Slope Aspect and Integrated Nutrient Management Effects on Crop Productivity and Soil Quality in North-west Himalayas, India显示文摘在农场简历资源上,再循环明确地与保存农业的介绍被给了更大的强调 withclimate 变化情形在西北 Himalaya 区域(NWHR ) 中间山。在这种变化情形,举起,斜坡方面和综合营养素下面,管理(INM ) 可以显著地影响土壤质量和庄稼生产率。研究处于一个 rainfed 条件在 NWHR 的 Ashti 分水岭在 20092010 ~ 20102011 期间被进行在土壤资源和庄稼生产率上检验举起,斜坡方面和综合滋养的管理(INM ) 的影响。二年农场示范试用显示庄稼生产率和土壤质量被举起,斜坡方面和 INM 显著地影响。结果证明改进技术的小麦等价物产量(WEY ) 与常规系统相比由 20%37% 增加了庄稼生产率。与豇豆和大豆玉米杂种由另一 8%17% 提高了产量。诺思方面和更高的举起与南方方面和低举起相比由 15%25% 增加了庄稼生产率(除了稻) 。与豇豆和大豆玉米杂种由另一 8%15% 提高了产量。不管斜坡,举起和收割系统, WEY 由于 INM 技术在这个区域增加了 30% 。举起,斜坡方面和 INM 的影响显著地影响了土壤资源(SQI ) 和土壤碳变化(SCC ) 。 SCC 显著地与 SQI 被相关为常规( R <啜class=“ a-plus-plus ”> 2 =0.65*), INM 技术( R <啜class=“ a-plus-plus ”> 2 =0.81*)并且为两种技术( R <啜class=“ a-plus-plus ”> 2 =0.73*)。它被推荐那在更高的举起。(除了稻土壤) 与面对斜坡的北方, INM 为更高的庄稼生产率被推荐;土壤资源的保存为 NWHR 的中间的山被推荐;并且 SCC 的单个价值作为为这个区域的 SQI 适当。 | Birendra Nath GHOSH Narinder Kumar SHARMA Nurnabi Meherul ALAM Raman Jeet SINGH Gopal Prasad JUYAL | 2014 | Journal of Mountain Science2014，11，5： | 3 |
| 4 | A LN2-based cooling system for a next-generation liquid xenon dark matter detector显示文摘In recent years, cooling technology for liquid xenon(LXe) detectors has advanced driven by the development of dark matter(DM) detectors with target mass in the 100–1000 kg range. The next generation of DM detectors based on LXe will be in the 50,000 kg(50 t)range requiring more than 1 k W of cooling power. Most of the prior cooling methods become impractical at this level.For cooling a 50 t scale LXe detector, a method is proposed in which liquid nitrogen(LN2) in a small local reservoir cools the xenon gas via a cold finger. The cold finger incorporates a heating unit to provide temperature regulation. The proposed cooling method is simple, reliable, and suitable for the required long-term operation for a rare event search. The device can be easily integrated into present cooling systems, for example the ‘‘Cooling Bus’ ’employed for the Panda X I and II experiments. It is still possible to cool indirectly with no part of the cooling or temperature control system getting in direct contact with the clean xenon in the detector. Also, the cooling device can be mounted at a large distance, i.e., the detector is cooled remotely from a distance of 5–10 m. The method was tested in a laboratory setup at Columbia University to carry out different measurements with a small LXe detector and behaved exactly as predicted. | Karl Ludwig Giboni Pratibha Juyal Elena Aprile Yun Zhang Junji Naganoma | 2020 | Nuclear Science and Techniques2020，31，8： | 2 |
| 5 | Geochemical signatures of Late Holocene paleo-hydrological changes from Phulera and Pokharan saline playas near the eastern and western margins of the Thar Desert,India显示文摘 | Roy P D Nagar Y C Juyal N | | 0，，3： | 1 |
| 6 | Plagiarism: an egregious form of misconduct 显示文摘 | Juyal D Thawani V Thaledi S | 2015 | N Am J Med Sci2015，7，2： | 1 |
| 7 | Pathology and therapy in naturally Eimeria stiedae-infected rabbits 显示文摘 | SINGLA L D JUYAL P D SANDHU B S | 2000 | J Protozool Res2000，10，4： | 1 |
| 8 | Evaluation of lateralclosed wedge high tibial osteotomy for medial compartmentosteoarthritis显示文摘 | YADAV V P JUYAL A SHARMA S | 2015 | Banglad J Med Sci2015，14，4： | 1 |
| 9 | Emergence of non-albicans Candida spe- cies in neonatal eandidemia显示文摘 | Juyal D Sharma M Pal S | 2013 | N Am J Med Sci2013，5，9： | 1 |
| 10 | Reconstruction of last gla-cial to early Holocene monsoon variability from relict lake sedimentsof the Higher Central Himalaya,Uttrakhand,India显示文摘 | Juyal N Pant R K Basavaiah N | 2009 | Journal ofAsian Earth Sciences2009，34，： | 1 |
| 11 | Pathological changes in Sarcocystis infection in domestic pigs (Sus scrofa ) 显示文摘 | AVAPAL R S SHARMA J K JUYAL P D | 2004 | Vet J2004，168，3： | 1 |
| 12 | Study of live oil wax precipitation with high-pressure micro-differential scanning calorimetry显示文摘 | Juyal P Cao T Yen A | 2011 | Energy & Fuels2011，25，2： | 1 |
| 13 | Sulfur speciation in petroleum : Atmospheric pressure photoionization or chemical derivatization and electrospray ionization fourier transform ion cyclotron resonance mass spectrometry 显示文摘 | PURCELL J M JUYAL P KIM D G | 2007 | Energy Fuels2007，21，： | 1 |
| 14 | Clinico-radiological profile of new smear positive pulmonary tuberculosis cases among young adult and elderly people in a tertiary care hospital at Deheradun (Uttarakhand)显示文摘 | Rawat J Sindhwani G Juyal R | | 0，，02： | 1 |
| 15 | A new secoiridoid gly- coside from Lonicera angustifolia 显示文摘 | Prasad D Juyal V Singh R | 2000 | Fitoterapia2000，71，4： | 1 |
| 16 | Environmental impact assessment of a few selected watersheds of the Chamoli district ( central Himalaya) usingremotely sensed data 显示文摘 | Kimothi Juyal | 1996 | International Journal of Remote Sensing1996，，： | 1 |
| 17 | On proportional scintillation in very large liquid xenon detectors显示文摘The charge readout of a liquid xenon(LXe)detector via proportional scintillation in the liquid phase was first realized by the Waseda group 40 years ago,but the technical challenges involved were overwhelming.Although the tests were successful,this method was finally discarded and eventually nearly forgotten.Currently,this approach is not considered for large LXe dark matter detectors.Instead,the dual-phase technology was selected despite many limitations and challenges.In two independent studies,two groups from Columbia University and Shanghai Jiao Tong University reevaluated proportional scintillation in the liquid phase.Both studies established the merits for very large LXe detectors,but the Columbia group also encountered apparent limitations,namely the shadowing of the light by the anode wires,and a dependence of the pulse shape on the drift path of the electrons in the anode region.The differences between the two studies,however,are not intrinsic to the technique,but a direct consequence of the chosen geometry.Taking the geometrical differences into account,the results match without ambiguity.They also agree with the original results from the Waseda group. | Pratibha Juyal Karl-Ludwig Giboni Xiang-Dong Ji Jiang-Lai Liu | 2020 | Nuclear Science and Techniques2020，31，9： | 1 |
| 18 | Population and genomic lessons from genetic analysis of two Indian populations显示文摘 | Garima Juyal Mayukh Mondal Pierre Luisi Hafid Laayouni Ajit Sood Vandana Midha Peter Heutink Jaume Bertranpetit B. K. Thelma Ferran Casals | 2014 | Human Genetics2014，，10： | 1 |
| 19 | Pathol- ogy and Therapy in Naturally Eimeria stiedae-Infec- ted Rabbits显示文摘 | SINGLA L D JUYAL P D SANDHU B S | 2000 | J Protozool Res2000，10，： | 1 |
| 20 | Hypoglycemic activity of aqueous extract of Urtica parviflora roxb in normoglycemic rats 显示文摘 | SAH SP SAH ML JUYAL V | 2010 | Int J Phytomedicine2010，2，： | 1 |
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