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| 1 | Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa显示文摘AIM: To analyze possible relationships between CA ⅠⅩ/CA Ⅻ and pVHL expression in normal and neoplastic colorectal mucosa.METHODS: Immunohistochemical staining of 42 tissue specimens obtained from 17 cancer patients was performed to evaluate the distribution and semi-quantitatively assess the levels of CA ⅠⅩ, CA Ⅻ and pVHL. VHL mRNAs from 14 fresh-frozen tumors was amplified by RT-PCR and subjected to sequencing. CA9 and CA12 mRNA levels were analyzed by semi-quantitative RT-PCR in comparison with VEGFas an indicator of hypoxia that uncouples the pVHL control.RESULTS: Tumor tissues were associated with a borderline increase of CA ⅠⅩ staining signal and slight but significant decrease of CA Ⅻ immunoreactivity, whereas no association was found for pVHL. Sequence analysis of RT-PCR-amplified VHL mRNAs revealed no deletions/mutations, suggesting that they were VHL-competent. We did not observe any correlation between pVHL and CA ⅠⅩ/CA Ⅻ proteins as well as between VEGF and CA9 mRNAs, but the tumor-associated changes in mRNA levels of VEGF and CA12 showed a significant inverse relationship.CONCLUSION: Our results indicate that CA9 and CA12 are regulated by different intratumoral factors and that lack of apparent relationship between the levels of CA ⅠⅩ/CA Ⅻ and pVHL cannot be fully assigned to uncoupling of negative regulatory function of pVHL by tumor hypoxia signified by induced VEGF transcription. The interplay between the functional pVHL and CA ⅠⅩ/CA Ⅻ in colorectal tumors seems rather complex and is not evident merely at the expression levels. | Antti J. Kivela Seppo Parkkila Juha Saarnio Tuomo J. Karttunen Jyrki Kivela Anna-Kaisa Parkkila Maria Bartosova Vojtech Mucha Michal Novak Abdul Waheed William S. Sly Hannu Rajaniemi Silvia Pastorekova Jaromir Pastorek | 2005 | World Journal of Gastroenterology2005，11，17： | 10 |
| 2 | Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer显示文摘AIM To characterize the expression of toll-like receptors(TLR) 2 and 4 in colorectal cancer(CRC) and in normal colorectal mucosa.METHODS We analysed tissue samples from a prospective series of 118 unselected surgically treated patients with CRC. Sections from formalin fixed, paraffin embedded specimens were analysed for TLR2 and TLR4 expression by immunohistochemistry. Two independent assessors evaluated separately expression at the normal mucosa, at the invasive front and the bulk of the carcinoma, and in the lymph node metastases when present. Expression levels in different locations were compared and their associations with clinicopathological features including TNM-stage and the grade of the tumour and 5-year follow-up observations were analysed.RESULTS Normal colorectal epithelium showed a gradient of expression of both TLR2 and TLR4 with low levels in the crypt bases and high levels in the surface. In CRC, expression of both TLRs was present in all cases and in the major proportion of tumour cells. Compared to normal epithelium, TLR4 expression was significantly weaker but TLR2 expression stronger in carcinoma cells. Weak TLR4 expression in the invasive front was associated with distant metastases and worse cancerspecific survival at 5 years. In tumours of the proximal colon the cancer-specific survival at 5 years was 36.9% better with strong TLR4 expression as compared with those with weak expression(P = 0.044). In contrast, TLR2 expression levels were not associated with prognosis. Tumour cells in the lymph node metastases showed higher TLR4 expression and lower TLR2 expression than cells in primary tumours.CONCLUSION Tumour cells in CRC show downregulation of TLR4 and upregulation of TLR2. Low expression of TLR4 in the invasive front predicts poor prognosis and metastatic disease. | Karoliina Paarnio Sara Vayrynen Kai Klintrup Pasi Ohtonen Markus J Makinen Jyrki Makela Tuomo J Karttunen | 2017 | World Journal of Gastroenterology2017，23，26： | 8 |
| 3 | Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours显示文摘Carbonic anhydrases (CAs) catalyse the hydration of CO2to bicarbonate at physiological pH. This chemical interconversion is crucial since HCO3- is the substrate for several biosynthetic reactions. This review is focused on the distribution and role of CA isoenzymes in both normal and pathological gastrointestinal (GI) tract tissues. It has been known for many years that CAs are widely present in the GI tract and play important roles in several physiological functions such as production of saliva, gastric acid, bile, and pancreatic juice as well as in absorption of salt and water in intestine. New information suggests that these enzymes participate in several processes that were not envisioned earlier. Especially, the recent reports on plasma membranebound isoenzymes Ⅸ and Ⅻ have raised considerable interest since they were reported to participate in cancer invasion and spread. They are induced by tumour hypoxia and may also play a role in von Hippel-Lindau (VHL)-mediated carcinogenesis. | Antti J. Kivel Jyrki Kivel Juha Saarnio Seppo Parkkila | 2005 | World Journal of Gastroenterology2005，11，2： | 4 |
| 4 | 与芬兰农业变化有关的草地中植物种类丰富度和生境连通度的降低显示文摘20世纪中,欧洲半天然草地严重减少,物种多样性降低,这与社会-经济因素密切相关。农业生产的发展驱动着土地利用的变化,从而控制着景观维持生物多样性的能力。本研究中,我们把农业生产变化和景观破碎化、物种多样性联系在一起。结果表明,半天然草地的停止放牧引起了景观结构的显著变化,并使维管束植物种的数目降低。放牧草场数量的下降主要是受与农业政策措施有关的农场水平的经济效果和收益率的影响。自1995年芬兰加入欧盟以来,由于对半天然草地经营有了扶持政策,我们研究地区中放牧斑块的面积又一次增加了。 | Miska Luoto Seppo Rikolainen Jyrki Aakkula Juha Pykl 王胜 | 2003 | AMBIO-人类环境杂志2003，32，7： | 3 |
| 5 | Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patients with new indications:A case series显示文摘Fecal microbiota transplantation(FMT) is effective in recurrent Clostridium difficile infection(r CDI). Knowledge of the safety and efficacy of FMT treatment in immune deficient patients is scarce. FMT has been suggested as a potential method for an increasing number of new indications besides r CDI. Among our FMT-treated r CDI patients, we reviewed those with major comorbidities: two human immunodeficiency virus patients, six haemodialysis patients, two kidney transplant patients, two liver transplant patients and a patient with chronic lymphatic leukaemia. We also reviewed those treated with FMT for indications other than r CDI: Salmonella carriage(two patients), trimethylaminuria(two patients), small intestinal bacterial overgrowth(SIBO;one patient), and lymphocytic colitis(one patient), as well as a common variable immunodeficiency patient with chronic norovirus infection and ESBL-producing Escherichia coli(E. coli) carriage. Of the thirteen r CDI patients treated with FMT, eleven cleared the CDI. The observed adverse events were not directly attributable to FMT. Concerning the special indications, both Salmonellas and ESBL-producing E. coli were eradicated. One trimethylaminuria patient and one SIBO-patient reported a reduction of symptoms. Three patients did not experience a benefit from FMT: chronic norovirus, lymphocytic colitis and the other fish malodour syndrome. There were no reported side effects in this group. FMT appeared to be safe and effective for immunocompromised patients with r CDI. FMT showed promise for the eradication of antibiotic-resistant bacteria, but further research is warranted. | Perttu Lahtinen Eero Mattila Veli-Jukka Anttila Jyrki Tillonen Matti Teittinen Pasi Nevalainen Seppo Salminen Reetta Satokari Perttu Arkkila | 2017 | World Journal of Gastroenterology2017，23，39： | 2 |
| 6 | A multi-attribute e-auction mechanism for procurement: Theoretical foundations显示文摘 | Jeffrey E. Teich Hannele Wallenius Jyrki Wallenius Alexander Zaitsev | 2005 | European Journal of Operational Research2005，，1： | 2 |
| 7 | 基于top-k显露模式的商品对比评论分析显示文摘随着电子商务的发展,许多购物网站都提供商品评论作为用户购物的决策参考。由于商品评论具有海量、冗余、不规范的特点,用户难以在短时间内浏览所有商品评论,更难以基于评论内容发现商品对比特征。对此,设计了top-k显露模式挖掘算法,并将此算法应用于商品评论对比分析,实现了用户购物决策支持系统——Review Scope。Review Scope能够从不同商品的评论中发现特定商品的对比评论,并以此作为购物决策可视化地提供给用户。基于京东商城真实商品评论数据的实验结果表明Review Scope具有有效、灵活、用户友好的特点。 | 刘璐 王怡宁 段磊 Jyrki Nummenmaa 晏力 唐常杰 | 2015 | 计算机应用2015，35，10： | 2 |
| 8 | Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients显示文摘AIM: To study whether the glucocorticoid receptor (GR/ NR3C1) gene haplotypes influence the steroid therapy outcome in inflammatory bowel disease (IBD). METHODS: We sequenced all coding exons and flanking intronic sequences of the NR3C1 gene in 181 IBD patients, determined the single nucleotide polymorphisms, and predicted the NR3C1 haplotypes. Furthermore, we investigated whether certain NR3C1 haplotypes are significantly associated with steroid therapy outcomes. RESULTS: We detected 13 NR3C1 variants, which led to the formation of 17 different haplotypes with a certainty of > 95% in 173 individuals. The three most commonly occurring haplotypes were included in the association analysis of the influence of haplotype on steroid therapy outcome or IBD activity. None of the NR3C1 haplotypes showed statistically signifi cant association with glucocorticoid therapy success. CONCLUSION: NR3C1 haplotypes are not related to steroid therapy outcome. | Jessica Mwinyi Christa Wenger Jyrki J Eloranta Gerd A Kullak-Ublick | 2010 | World Journal of Gastroenterology2010，16，31： | 2 |
| 9 | Extrusionspheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery 显示文摘 | Karin Krogars Jyrki Heinamaki Johanna Vesalahti | 2000 | International Journal of Pharmaceutics2000，，199： | 1 |
| 10 | Multiple Criteria Decision Making, Multiattribute Utility Theory: Recent Accomplishments and What Lies Ahead显示文摘 | Jyrki Wallenius Jmnes S Dyer Peter C Fishburn | 2008 | Management Science2008，54，7： | 1 |
| 11 | Determinants of Food Price Inflation in Finland:The Role of Energy 显示文摘 | Irz X Jyrki N Liu X | 2013 | Energy Policy2013，63，： | 1 |
| 12 | Managing Knowledge and Knowledge competences in projects and project organizations显示文摘 | Kasvi J J Jyrki Vartiainen Matti Hailikari Milla | 2003 | International Journal of Project Management2003，21，： | 1 |
| 13 | PREVENTION OF SYSTEMIC HYPERLACTATEMIA DURING SPLANCHNIC ISCHEMIA显示文摘 | Stephan M. Jakob Minna Merasto-Minkkinen Jyrki J. Tenhunen Antero Heino Esko Alhava Jukka Takala | 2000 | Shock2000，，2： | 1 |
| 14 | Gas chromatographic determination of some alkoxysilanes for use in occupational exposure assessment显示文摘 | Jukka Maittala Sirpa Pennanena Jyrki Liesivuori | 1999 | The Analyst1999，124，： | 1 |
| 15 | The use of value focused thinking and the SWOT hybrid method in tourism management显示文摘 | Miika K Jyrki K Mikko K | 2004 | Tourism Management2004，6，25： | 1 |
| 16 | Integrating spatial multi-criteria evaluation and expert knowledge for GIS-based habitat suitability modeling显示文摘 | Ron Kangas Jyrki | 2001 | Landscape and Urban Planning2001，，55： | 1 |
| 17 | Managing knowledge and knowledge competences in projects and project organizations显示文摘 | Kasvi J J Jyrki Vartiainen Matti Hailikari Milla | 2003 | International Journal of Project Management2003，21，： | 1 |
| 18 | Prediction of physicochemical properties based on neural network modeling 显示文摘 | Jyrki Taskinen Jouko Yliruusi | 2003 | Adv Drug Delivery Rev2003，55，： | 1 |
| 19 | Local and distortional buckling of thin-walled short columns显示文摘 | JYRKI KESTI J MICHAEL DAVIES | 1999 | Thin-walled Structures1999，34，： | 1 |
| 20 | Tryptophan depletion effects on EEG and MEG responses Suggest serotonergic modulation of auditory involuntary attention in humans 显示文摘 | Jyrki A Seppo K Sirpa P | 2002 | Neuroimaging2002，16，： | 1 |
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