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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Adipose tissue resistin levels in patients with anorexia nervosa 显示文摘 | Ivana D Marie K Jaroslava D | 2006 | Nutrition2006，22，10： | 1 |
| 3 | Two-dimensional Assembling of Au Nanoparticles Mediated by Tetrapyridylporphine Molecules 显示文摘 | Ivana S S Blanka V k | 2002 | Nano Lett2002，2，： | 1 |
| 4 | Influence of the emission trading scheme on generation scheduling显示文摘 | Ivana K Conejo A J James R M | 2009 | Inter- national Journal of Electrical Power and Energy Systems2009，31，9： | 1 |
| 5 | Anatomical termi- nology and nomenclature: past, present and high- lights显示文摘 | David K Vaclav B Ivana B | 2008 | Surg Radiol Anat2008，30，6： | 1 |
| 6 | Decreased numbers of regulatory t cells suggest impaired immune tolerance in children with tourette syndrome 显示文摘 | Ivana K James FL | 2007 | Biological psychiatry2007，61，： | 1 |
| 7 | 3D reinforcement of stiffener-to-skin T-joints by Z-pinning and tufting显示文摘 | Denis D R Carrie Giuseppe Dell Anno Emilie Poulin Ivana K Partridge | 2006 | Engineering Fracture Mechanics2006，73，16： | 1 |
| 8 | Scanning electron microsco- py investigation of canal cleaning after canal preparation with nickel-titanium files 显示文摘 | Brkanic T Ivana S Vukoje K | 2010 | Srp Arh Celok Lek2010，138，910： | 1 |
| 9 | Thermal development of microstructure and precipitation effects in Mg-10%wtGd alloy显示文摘 | JAKUB C IVAN P BOHUMIL A IVANA S RADOMIR K ZDENEK M J VIKTOR C | 2006 | Phys Star A2006，203，： | 1 |
| 10 | Exploring mechanical property balance in tufted carbon fabric/epoxy composites 显示文摘 | Giuseppe Dell Anno Denis D Cartie Ivana K Partridge Amir Rezai | 2007 | Composites2007，38，： | 1 |
| 11 | Chaperone activity of recombinant maize chloroplast protein synthesis elongation factor, EF-Tu Eur显示文摘 | Damodara R Ivana M Satoru K | 2004 | Biochem2004，271，： | 1 |
| 12 | Delamination resistant laminates by Z-fiber pirming: Part Ⅰ nlanufaeture and fracture performance显示文摘 | Ivana K Partridge Denis D R Cartie | 2005 | Composites: Part A2005，36，1： | 1 |
| 13 | Apical leaking of five rot canal sealers after one year of storage显示文摘 | Ivana M Sonja-Pezelj R Zoran K | 2002 | J Endo2002，28，6： | 1 |
| 14 | Imaging of moving targets with multi-static SAR using an overcomplete dictionary 显示文摘 | IVANA S WILLIAM C K | 2010 | IEEE Journal of Selected Topics in Signal Processing2010，4，1： | 1 |
| 15 | Sonochemical effectivenessfactor ( eUS ) in the reactors for wastewater treatment by sono-Fenton oxidation : novel considerations 显示文摘 | IVANA G SANJA P NATALIJIA K | 2013 | UltrasonicsSonochemistry2013，20，： | 1 |
| 16 | Purification and properties of extracellular lipase from Streptomyces rimosus, Enzyme显示文摘 | Marija A Ivana L Tamara K | 1999 | Microbiol Technol1999，25，： | 1 |
| 17 | Xanthones and C-glucosides from the aerial parts of four species of Gentianella from Serbia and Montenegro 显示文摘 | Teodora J Dijana K Ivana A | 2005 | Biochem Syst Ecol2005，33，7： | 1 |
| 18 | Scanning electron microscopy investigation of canal cleaning after canal preparationwith nickel titanium flies 显示文摘 | BrkaniBrkani6 T Ivana S Vukoje K | 2010 | Srp Arh Celok Lek2010，138，910： | 1 |
| 19 | Scanning electron microscopy investigation of canal cleaning after canal preparation with nickel titanium files 显示文摘 | Brkanic T Ivana S Vukoje K | 2010 | Srp Arh Celok Lek2010，138，910： | 1 |
| 20 | Segmentation and tracking in echocardiographic sequences:active contour guided by optical flow estimates显示文摘 | Ivana M Slawomir K James D T | 1998 | IEEE Trans on Medical Imaging1998，17，2： | 1 |
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