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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Apoptosls and expression of Bcl-2 in human endometrium in natural and artificial cycles显示文摘 | PAVEL H IVANA O JANA B | 2005 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2005，149，2： | 1 |
| 3 | Anatomical termi- nology and nomenclature: past, present and high- lights显示文摘 | David K Vaclav B Ivana B | 2008 | Surg Radiol Anat2008，30，6： | 1 |
| 4 | Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis显示文摘 | Sara A McCartney Anne B Ballinger Ivana Vojnovic Michael J.G Farthing Timothy D Warner | 2002 | Life Sciences2002，，： | 1 |
| 5 | Phase transformations due to isochronal annealing of Mg-rare earth-Sc-Mn squeeze cast alloys显示文摘 | BOHUMIL S IVANA S JITKA P FRANK V B BARRY L B | 2003 | Z Metallkd2003，94，： | 1 |
| 6 | & S显示文摘 | Dennis Davidson NF-κB activation in tumor necrosis factor-α stimulated neutrophils is mediated by protein kinase C | 2001 | J Bil Chem2001，276，19： | 1 |
| 7 | Irinotecan/5-Florouracil Combination Induces Alterations in Mitochondrial Membrane Potential and Caspases on Colon Cancer Cell Lines显示文摘 | Ivana G Andrea R Adriana B R | 2005 | Oncology Research2005，15，： | 1 |
| 8 | Fluorinated Heterocyclic Compounds:an Assay on the Photochemistry of Some Fluorinated 1-Oxa-2-azoles:An Expedient Route to Fluorinated Heteroeycles显示文摘 | SILVESTRE B ANDREA P IVANA V | 2004 | Journal of Fluorine Chemistry2004，125，2： | 1 |
| 9 | Competitive inhibitors of enzymes and their therapeutic application显示文摘 | Gordana B Ivana S Goran B | 2002 | Medicine and Biology2002，9，3： | 1 |
| 10 | The centriolar satellite protein SSX2IP promotes centrosome maturation显示文摘 | Felix B?renz Daigo Inoue Hideki Yokoyama Justus Tegha-Dunghu Stephanie Freiss Stefanie Draeger Dmytro Mayilo Ivana Cado Sabine Merker Maren Klinger Burkhard Hoeckendorf Sahra Pilz Kerstin Hupfeld Herbert Steinbeisser Holger Lorenz Thomas Ruppert Joachim W | 2013 | The Journal of Cell Biology2013，，1： | 1 |
| 11 | Phenol content, antioxidant activity and metal composition of croatian wines deriving from organically and conven- tionally grown grapes显示文摘 | IVANA V V MIRZA B IRENA Z | 2011 | Food Chemistry2011，124，： | 1 |
| 12 | Malachite green residues in fanned fish in Croatia显示文摘 | Nina B Ivana V Bozica S K | 2012 | Food Control2012，26，： | 1 |
| 13 | Current state of mineral nutrition and risk elements in a beech ecosystem situated near the aluminium smelter in Ziar nad hronom, central slovakia显示文摘 | GABRIELA J KATARiNA B IVANA H | 2007 | Forest Ecology and Management2007，248，： | 1 |
| 14 | Spontaneous tendon ruptures in patients with end-stage renal discasc显示文摘 | Nikolina B J Ivana J Sanjian R | 2009 | Kidney Blood Pressres2009，32，1： | 1 |
| 15 | Apoptosis and expression of Bel-2 in hu- man endometrium in natural and artifieial cycles 显示文摘 | Pavel H Ivana O Jana B | 2005 | Biomed Pap Med Fae Univ Palaeky Olomoue Czech Repub2005，149，2： | 1 |
| 16 | Reinitiation of cell division and polyamine and aromatic monoamine levels in alfalfa explants during the induction of somatic embryogenesis显示文摘 | MILENA C PAVLA B VERA C MILENA C PAVLA B VERA C JOSEF E IVANA C M | 1999 | Physiologia Plantarum1999，105，： | 1 |
| 17 | Addition of polyethersulphone to epoxy resins显示文摘 | Bucknall Clive B Partridge Ivana K | 1983 | British Polymer Journal1983，15，1： | 1 |
| 18 | 查看详情显示文摘 | Juliana F S D Cassia C F A Ivana G Adriana B R Mario G C | | 0，，04： | 1 |
| 19 | Supramolecular complex of fluoxetine with β-cyclodextrin: An experimental and theoretical study显示文摘 | Frederico B S Ivana S L Juliana F L | 2008 | International Journal of Pharmaceutics2008，353，： | 1 |
| 20 | Ab initio study of pristine and Si-doped capped carbon nanotubes interacting with nimesulide molecules显示文摘 | IVANA Z SOLANGE B FAGAN R | 2007 | Chem Phys Lett2007，439，46： | 1 |
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