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| 1 | 早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。 | 刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G | 2017 | 中华高血压杂志2017，25，4： | 5 |
| 2 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 3 | Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings显示文摘 | Andreas A. Schnitzbauer Sven A. Lang Holger Goessmann Silvio Nadalin Janine Baumgart Stefan A. Farkas Stefan Fichtner-Feigl Thomas Lorf Armin Goralcyk Rüdiger H?rbelt Alexander Kroemer Martin Loss Petra Rümmele Marcus N. Scherer Winfried Padberg Alfred K? | 2012 | Annals of Surgery2012，，3： | 2 |
| 4 | Best Practices in Managing Investor Relations Websites: Directions for Future Research显示文摘 | Bollen Laury H Hassink Harold F de Lange Rindert K Buijl Saskia D | 2008 | Journal of Information Systems2008，，2： | 2 |
| 5 | Mixture toxicity of nitrobenzene and trinitrobenzene using the marine bacterium Vibrio harveyl as the test organism显示文摘 | Thomulka K W Lange J H | 1997 | Ecotoxicity and Environmental Safety1997，36，2： | 2 |
| 6 | Xanthogranulomatous cholecystitis resembling carcinoma with extensive tumorous infiltration of the liver and colon显示文摘 | Jürgen Pinocy Antje Lange Claudius K?nig Edwin Kaiserling Horst D. Becker Stefan M. Kr?ber | 2003 | Langenbeck’s Archives of Surgery2003，，1： | 2 |
| 7 | Factors influencing the prognostic role of estrogen and progesterone receptor levels in breast cancer-results of the analysis of 670 patiens with 11 years of follow-up显示文摘 | Costa SD Lange S Klinga K | 2002 | Eur J Cancer2002，38，： | 1 |
| 8 | CXC chemokine receptor 5 expression defines follicular homming T cells with b cell helper function显示文摘 | Schaerli P Willimann K Lang AB | 2000 | J Exp Med2000，192，11： | 1 |
| 9 | Surface NMR within a Geophysical Study of an Aqui{er at Halden- sleben (Germany) 显示文摘 | Yaramanci U Lange G Knodel K | 1999 | Geophysical Prospecting1999，47，： | 1 |
| 10 | Translating biomolecular recognition into nanomechanics显示文摘 | Fritz J Bailer M K Lang H P | 2000 | Science2000，288，： | 1 |
| 11 | Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA:implications for post-transcriptional regulation of the CYP2A6 gene显示文摘 | Lang M Maurl P | 2004 | Mol Pharmacol2004，65，6： | 1 |
| 12 | The outcomes and costs of acute myeloid leukemia among the elderly 显示文摘 | Menzin J Lang K Earle CC | 2002 | Arch Inter Med2002，162，： | 1 |
| 13 | Colloids versus crystalloids and tissue oxygen tension in patient s undergoing major abdominal surgery显示文摘 | Lang K Boldt J Suttner S | 2001 | Anesth Analg2001，93，： | 1 |
| 14 | Continuous intra-and postoperative thoracic epidural analgesia attenuates brain natriuretic peptide release after major abdominal surgery显示文摘 | SUTTNER S LANG K PIPER S N | 2005 | Anesth Analg2005，101，3： | 1 |
| 15 | Hydrothermal epitaxy of KTaO3 thin films显示文摘 | GOH G K L LEVI C G LANGE F F | 2002 | J Mater Res2002，17，11： | 1 |
| 16 | Enterprise decision support using Intranet technology显示文摘 | S Ba K R Lang A B Whinston | 1997 | Decision Support Systems1997，，20： | 1 |
| 17 | Endotoxin impairs the human pacemaker current If显示文摘 | Zorn-Pauly K Pelzmann B Lang P | 2007 | Shock2007，28，6： | 1 |
| 18 | Probable modern analogue of Kuroko-type massive sulfide deposits in the Okinawa Through back-arc basin显示文摘 | Halbach P Nakamura K W Lange J | 1989 | Nature1989，338，： | 1 |
| 19 | Advanced oxidation processes for treating groundwater contaminated with TCE and PCE:pilot scale evaluations显示文摘 | Aieta E M Regan K M Lang J S | 1998 | AWWA1998，80，： | 1 |
| 20 | Expression of vascular endothelial growth factor and thrombospondin 1 mRNA in patients with endometriosis显示文摘 | Tan X J Lang JH Shen K | 2003 | Fertil Steril2003，78，1： | 1 |
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