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| 1 | Liver fat content determined by magnetic resonance imaging and spectroscopy显示文摘Hepatic steatosis as the most prevalent liver disorder can either be related to alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD). In both conditions, hepatocytes excessively accumulate fatcontaining vacuoles within their cytoplasm, which is the key histological feature. In contrast to ALD, NAFLD is commonly associated with metabolic syndrome, obesity and insulin resistance. To determine increased liver fat content, liver biopsy is currently considered the gold standard. Besides the invasive technique, various other non-invasive techniques have been developed, such as ultrasound, computed tomography (CT), magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) based methods. Among these techniques, ultrasound and CT provide only qualitative information about hepatic steatosis, whereas MRS-or MRI-based methods are able to determine even small amounts of fat accurately. These non-invasive magnetic resonance techniques have already proven their great potential, especially in longitudinal and cross-sectional studies regarding various metabolic conditions and medical treatment regimens. In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations. | Fabian Springer Jürgen Machann Claus D Claussen Fritz Schick Nina F Schwenzer | 2010 | World Journal of Gastroenterology2010，16，13： | 19 |
| 2 | Impact of lattice relaxations on phase transitions in a high-entropy alloy studied by machine-learning potentials显示文摘Recently,high-entropy alloys(HEAs)have attracted wide attention due to their extraordinary materials properties.A main challenge in identifying new HEAs is the lack of efficient approaches for exploring their huge compositional space.Ab initio calculations have emerged as a powerful approach that complements experiment.However,for multicomponent alloys existing approaches suffer from the chemical complexity involved.In this work we propose a method for studying HEAs computationally.Our approach is based on the application of machine-learning potentials based on ab initio data in combination with Monte Carlo simulations.The high efficiency and performance of the approach are demonstrated on the prototype bcc NbMoTaW HEA.The approach is employed to study phase stability,phase transitions,and chemical short-range order.The importance of including local relaxation effects is revealed:they significantly stabilize single-phase formation of bcc NbMoTaW down to room temperature.Finally,a so-far unknown mechanism that drives chemical order due to atomic relaxation at ambient temperatures is discovered. | Tatiana Kostiuchenko Fritz Körmann Jörg Neugebauer Alexander Shapeev | 2019 | npj Computational Materials2019，，1： | 17 |
| 3 | Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance显示文摘 | Nina F. Schwenzer Fabian Springer Christina Schraml Norbert Stefan Jürgen Machann Fritz Schick | 2009 | Journal of Hepatology2009，，3： | 4 |
| 4 | 假膜性结肠炎的CT诊断显示文摘 | Schulze M Fritz J Joanoviciu SD Horger M Tbingen 曹毅媛(译) 胡道予(校) | 2009 | 放射学实践2009，24，5： | 4 |
| 5 | High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet显示文摘 | Günther Silbernagel Marketa Kovarova Alexander Cegan Jürgen Machann Fritz Schick Rainer Lehmann Hans-Ulrich H?ring Norbert Stefan Erwin Schleicher Andreas Fritsche Andreas Peter | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 3 |
| 6 | Analysis of rapid degradation in high-power (AlGa)As laser diodes, Quantum Electronics显示文摘 | Fritz W J | 1990 | IEEE Journal1990，26，： | 2 |
| 7 | Temperature-dependent phonon spectra of magnetic random solid solutions显示文摘A first-principles-based computational tool for simulating phonons of magnetic random solid solutions including thermal magnetic fluctuations is developed.The method takes fluctuations of force constants due to magnetic excitations as well as due to chemical disorder into account.The developed approach correctly predicts the experimentally observed unusual phonon hardening of a transverse acoustic mode in Fe–Pd an Fe–Pt Invar alloys with increasing temperature.This peculiar behavior,which cannot be explained within a conventional harmonic picture,turns out to be a consequence of thermal magnetic fluctuations.The proposed methodology can be straightforwardly applied to a wide range of materials to reveal new insights into physical behaviors and to design materials through computation,which were not accessible so far. | Yuji Ikeda Fritz Körmann Biswanath Dutta Abel Carreras Atsuto Seko Jörg Neugebauer Isao Tanaka | 2018 | npj Computational Materials2018，，1： | 2 |
| 8 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 9 | Acid catalysis by dealuminated zeolite-Y I Methanol dehydration and cumene dealkylation显示文摘 | DECANIO S J SOHN J R FRITZ P O | 1986 | Journal of Catalysis1986，101，1： | 1 |
| 10 | Fractionation of sulfur and oxygen isotopes in sulfate by soil sorption 显示文摘 | van Stempvoort D R Reardon E J Fritz P | 1990 | Geochim Cosmochim Acta1990，54，10： | 1 |
| 11 | Translating biomolecular recognition into nanomechanics显示文摘 | Fritz J Bailer M K Lang H P | 2000 | Science2000，288，： | 1 |
| 12 | Conservation of Bmp2 post-transcriptional regulatory mechanisms 显示文摘 | Fritz D T Liu D Xu J | 2004 | J Biol Chem2004，279，48： | 1 |
| 13 | Genistein action in the prepubertal mammary gland in a chemoprevention model显示文摘 | COTRONEO M S WANG J FRITZ W A | 2002 | Carcinogenesis2002，23，9： | 1 |
| 14 | Cadmium in upland forests after vitality fertilization with wood ash-a summary of soil microbiological studies into the potential risk of cadmium release 显示文摘 | Perkiomtoki J Fritze H | 2005 | Biology and Fertility of Soils2005，41，： | 1 |
| 15 | Uhrastructure of Two Toxic Marine Dinoflagellates, Prorocentrum Lima and Prorocentrum Maculosum 显示文摘 | Zhou J Fritz L | 1993 | Phycologia1993，32，6： | 1 |
| 16 | 查看详情显示文摘 | Tanaka K Fritz J S | | 0，，： | 1 |
| 17 | The Sukari gold mine,eastern Desert-Egypt:structural setting,mineralogy and fluid inclusion study显示文摘 | Helmy H.M Kaindl R Fritz H Loizenbauer J | | 0，，： | 1 |
| 18 | Cell aggregation of Pseudomonas aeruginosa strain PAO1 as an energy- dependent stress response during growth with sodium dodecyl sulfate显示文摘 | Klebensberger J Rui O Fritz E | 2006 | Archives of microbiology2006，185，6： | 1 |
| 19 | The effect of sodium poisoning on dealuminated Y-type zeolites显示文摘 | FRITZ P O LUNSFORD J H | 1989 | Journal of Catalysis1989，118，1： | 1 |
| 20 | Seasonal chemical and isotopic variations of soil CO2 at Trout Creek,Outario显示文摘 | REARDON E J ALLISON G B FRITZ P | 1979 | Journal of Hydrology1979，43，1： | 1 |
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