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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 3 | Endoscopic innovations to increase the adenoma detection rate during colonoscopy显示文摘Up to a quarter of polyps and adenomas are missed during colonoscopy due to poor visualization behind folds and the inner curves of flexures,and the presence of flat lesions that are difficult to detect.These numbers may however be conservative because they mainly come from back-to-back studies performed with standard colonoscopes,which are unable to visualize the entire mucosal surface.In the past several years,new endoscopic techniques have been introduced to improve the detection of polyps and adenomas.The introduction of high definition colonoscopes and visual image enhancement technologies have been suggested to lead to better recognition of flat and small lesions,but the absolute increase in diagnostic yield seems limited.Cap assisted colonoscopy and water-exchange colonoscopy are methods to facilitate cecal intubation and increase patients comfort,but show only a marginal or no benefit on polyp and adenoma detection.Retroflexion is routinely used in the rectum for the inspection of the dentate line,but withdrawal in retroflexion in the colon is in general not recommended due to the risk of perforation.In contrast,colonoscopy with the Third-Eye Retroscope?may result in considerable lower miss rates compared to standard colonoscopy,but this technique is not practical in case of polypectomy and is more time consuming.The recently introduced Full Spectrum Endoscopy?colonoscopes maintains the technical capabilities of standard colonoscopes and provides a much wider view of 330 degrees compared to the 170 degrees with standard colonoscopes.Remarkable lower adenoma miss rates with this new technique were recently demonstrated in the first randomized study.Nonetheless,more studies are required to determine the exact additional diagnostic yield in clinical practice.Optimizing the efficacy of colorectal cancer screening and surveillance requires high definition colonoscopes with improved virtual chromoendoscopy technology that visualize the whole colon mucosa while maintaining optimal washing,suction and therapeutic capabilities,and keeping the procedural time as low and patient discomfort as optimal as possible. | Vincent K Dik Leon MG Moons Peter D Siersema | 2014 | World Journal of Gastroenterology2014，20，9： | 6 |
| 4 | Intussusception in adults: institutional review 1 1 No competing interests declared.显示文摘 | Leon K Eisen John D Cunningham Arthur H Aufses | 1999 | Journal of the American College of Surgeons1999，，4： | 3 |
| 5 | Monitoring systems for steam turbine blade faults 显示文摘 | LEON R L TRAINOR K | 1990 | Sound and vibration1990，，2： | 1 |
| 6 | Alzheiner's disease显示文摘 | BLENNOW K DE LEON MJ ZETTERBERG H | 2006 | Lancet2006，368，9533： | 1 |
| 7 | Genome-wide atlas of transcription through maize development显示文摘 | Sekhon R S Lin H Childs K L Hirsch C N Buell C R de Leon N Kaeppler S M | 2011 | The Plant Journal2011，66，4： | 1 |
| 8 | Alzheimer's disease显示文摘 | Blennow K de Leon MJ Zetterberg H | 2006 | Lancet2006，368，9533： | 1 |
| 9 | De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial 显示文摘 | Leone M Bechis C Baumstarck K | 2014 | Intensive Care Med2014，40，10： | 1 |
| 10 | Alzheimer's disease显示文摘 | Blennow K de leon MJ Zetterberg H | 2006 | Lancet2006，368，9533： | 1 |
| 11 | Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy显示文摘 | Roy K Mao H Leon S | 1999 | Nature Medicine1999，5，4： | 1 |
| 12 | Transfection of human ran23 - h1 into the human MDA - MB - 435 breast carcinoma cell line: effects on tumor metastatic potential,colonization and enzymatic activity显示文摘 | Leone A Flatow U VanHoutte K | 1993 | Oncogene1993，8，9： | 1 |
| 13 | Alzheimer's disease显示文摘 | de Leon MJ Zetterberg H | 2006 | Lancet2006，368，： | 1 |
| 14 | Temporal bone disease:a comparison between high resolution computed tomography and pluridirectional tomography显示文摘 | Chat V Mohammad S Leon K | 1983 | Radiology1983，147，： | 1 |
| 15 | Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair ceils 显示文摘 | Leon SJ Oshima K Heller S | 2007 | Mol Cell Neurosci2007，34，1： | 1 |
| 16 | Epidemiology of diabetic foot 显示文摘 | Leone S Pascale K Vitale M | 2012 | Infez Med2012，20，1： | 1 |
| 17 | Associations between ozone and daily mortality: analysis and meta-analysis显示文摘 | ho K De Leon SF Lippmann M | 2005 | Epidemiology2005，16，4： | 1 |
| 18 | Alzheimer's disease显示文摘 | Blennow K de Leon MJ Zetterberg H | 2006 | Lancet2006，368，： | 1 |
| 19 | Alzheimer' s Disease 显示文摘 | Blennow K de Leon M J Zetterberg H | 2006 | Lancet2006，368，9533： | 1 |
| 20 | Rapid communication : Localization of POUI F1 to bovine, ovine,and caprine 1@1-22 显示文摘 | WOOLLARD J TUGGLE C K PONCE DE LEON F A | 2000 | J Anim Sci2000，78，1： | 1 |
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