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| 1 | Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery显示文摘为指向的同时的肿瘤的 Subcellular 细胞器特定的 nanoparticles,成像,和药交货具有对癌症治疗的庞大的兴趣。此处,我们报导一根选择指向线粒体的探针 1,它被与 cyanostilbene 和长烷基链一半合并 triphenyl 磷化氢综合。探查 1 被发现经由导致聚集的排放(AIE ) 显示荧光。低分子重量的基于 cyanostilbene 的探查有或没有 anticancer 药, 1 与 ca 形成了狭窄的同类的 nanorod。有 ca 的长度或 nanoparticles 的 110 nm。在水的媒介的 20 nm 直径。自我装配的 cyanostilbene nanoparticles (N1 ) 有选择地在癌症房间的线粒体积累了并且射出荧光。N1 也能交付 anticancer 药, doxorubicin (纪录影片) ,到有高效率的线粒体。更重要地, N1 在正常房间上为癌症房间展出了高度选择的 cytotoxicity。到生物系统的这自我装配的 nanoparticle 的大潜在的应用程序源于它在线粒体聚集的能力。这聚集在癌症房间在 mitochondrial 膜潜力在细胞内部的反应的氧种类并且到减少的产生导致了重要增加。而且,在老鼠的肿瘤织物举起实验建议自我装配的 N1 有能力使内在化并且有效地交付 anticancer 药进肿瘤纸巾。而且, N1 和包含 N1 的 doxorubicin (N1 纪录影片) 有效地在 vivo 在一个异种皮移植模型压制了肿瘤生长。一起拿,我们的调查结果显示 N1 的应用程序为潜在的指导图象的治疗以及一个地点特定的交货系统作为指向探查,药交货平台,和化学疗法的代理人的 mitochondrial 提供唯一的策略给癌症房间。 | Ka Young Kim Hanyong Jin Jaehyeon Park Sung Ho Jung Ji Ha Lee Hyesong Park Sung Kuk Kim Jeehyeon Bae Jong Hwa Jung | 2018 | Nano Research2018，11，2： | 4 |
| 2 | Quadriceps tendon free graft augmentation for a midsubstance tear of the medial collateral ligament during total knee arthroplasty显示文摘 | Jung KA Lee SC Hwang SH | 2009 | Knee2009，16，6： | 1 |
| 3 | Upregulation of IFN-gamma receptor expression by proinflammatory cytokines influences IDO activation in epithelial cells显示文摘 | Shirey KA Jung JY Maeder GS | 2006 | J Interferon Cytokine Res2006，26，1： | 1 |
| 4 | Arthroscopic synovectomy of the knee joint in rheumatoid arthritis:surgical steps for complete synovectomy显示文摘 | Kim SJ Jung KA Kwun JD | 2006 | Arthroscopy2006，22，： | 1 |
| 5 | The short-term follow- up results of open wedge high tibial osteotomy with u- sing an aescula open wedge plate and an allogenic bone graft: the minimum 1-year follow-up results 显示文摘 | Lee SC Jung KA Nam CH | 2010 | Clin Orthop Surg2010，2，1： | 1 |
| 6 | The short-term follow-up results of open wedge high tibial osteotomy with using an Aescula open wedge plate and an allogenic bone graft:the minimum 1-year follow-up results显示文摘 | Lee SC Jung KA Nam CH | | 0，，01： | 1 |
| 7 | Drug - Induced Liver Inju- ry:TWenty Five Cases of Acute Hepatitis Following Ingest- ion of Polygonum multiflorum Thunb显示文摘 | Jung KA Min H J Yoo SS | 2011 | Gut Liver2011，5，4： | 1 |
| 8 | Genetic Diversity of Echovirus 6 strains Circulating in Korea 显示文摘 | Jung EH Park KS Back KA | 2010 | J Bacteriol Virel2010，40，4： | 1 |
| 9 | The NRF2-heme oxygenase- 1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis 显示文摘 | Shin DH Park HM Jung KA | 2010 | Free Radic Bid Meal2010，48，8： | 1 |
| 10 | Bond strength of a new universal self-adhesive resin luting cement to dentin and enamel显示文摘 | Abo-Hamar SE Hiller KA Jung H | 2005 | Clinical Oral Investigations2005，9，： | 1 |
| 11 | Is further treatment necessary for patellar crepitus after total knee arthroplasty 显示文摘 | Hwang BH Nam CH Jung KA | 2013 | Clin Orthop2013，2，： | 1 |
| 12 | The NRF2-heme oxygenase-1 A-induced epithelial-mesenchymal transition and renal fibrosis 显示文摘 | Shin DH Park HM Jung KA system modulates cyclospofin | 2010 | Free Radic Biol Med2010，48，8： | 1 |
| 13 | Arthroscopic synovectomy of the knee joint in rheumatoid arthritis:surgical steps for complete synovectomy显示文摘 | Kim SJ Jung KA Kwun JD | 2006 | Arthroscopy2006，22，4： | 1 |
| 14 | Antifatigue effect of Rubus coreanus Miquel extract in mice显示文摘 | KA Jung D Han EK Kwon | 2007 | J Med Food2007，10，4： | 1 |
| 15 | Effects of BT-11 on memory in healthy humans显示文摘 | Jun-Young Lee Ka Young Kim Ki Young Shin Beom Young Won Hee Yeon Jung Yoo-Hun Suh | 2009 | Neuroscience Letters2009，，2： | 1 |
| 16 | Antifatigue Effect of Rubus coreanus Miquel Extract in Mice显示文摘 | Jung KA Han D Kwon EK | 2007 | J Med Food2007，10，4： | 1 |
| 17 | Upregulation of IFN-γ receptor expression by proinflamroatory eytokines Influences IDO activation in epithelial cells 显示文摘 | Shirey KA Jung JY Maeder GS | 2006 | J Interferon Cytokine Res2006，26，1： | 1 |
| 18 | Di-ospyros kaki extract inhibits alkali bum-induced cornealneovascularization显示文摘 | YANG SJ JO H KIM KA AHN HR KANG SW JUNG SH | 2016 | J Med Food2016，19，1： | 1 |
| 19 | 'Fine-tuned' correction of tibial slope with a temporary external fixator in opening wedge high-tibi- al osteotomy显示文摘 | Jung KA Kim SJ Lee SC | 2008 | Knee Surg Sports Traumatol Arthrosc2008，16，3： | 1 |
| 20 | Drug-Induced Liver Injury : Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb 显示文摘 | Jung KA Min H J Yoo SS | 2011 | Gut Liver2011，5，4： | 1 |
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