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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer 显示文摘	Kafka A Sauer G Jaeger C	2003	Int J Oncol2003，22，5：	1
3	High-fidelity tissue en- gineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities显示文摘	Reiffel A J Kafka C Hernandez K A	2013	Plos One2013，8，2：	1
4	Conversion effi- cacy of intravenous ibutilide compared with intravenous amiodarone in patients with recent-onset atrial fibrillation and atrial flutter 显示文摘	Kafkas N V Patsilinakos S P Mertzanos G A	2007	Int J Cardiol2007，118，3：	1
5	Coronary bypass graft fate and patient outcome:angiographic follow -up of 5065 grafts related survival and reoperation in 1388 patients during 25 years 显示文摘	Fitzgibbon G M Kafka H P Leach A J	1996	J Am Coil Cardiol1996，28，：	1
6	Polymorphism C2435T of the MDRI gene predicts response to preoperative ehemotherapy in locally advanced breast cancer 显示文摘	Kafka A Sauer G Jaeger C	2003	Int J Oneol2003，22，5：	1
7	Coronary bypass graft fate and patient outcome:angicgraphicfollow-up of 5 065 grafts related to survival and reoperation in 1 388 patients during 25 years显示文摘	Fitzgibben GM Kafka HP Leach A J	1996	J Am Coll cardiol1996，28，3：	1
8	Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer显示文摘	KAFKA A SAUER G JEAQER C	2003	Int J Oncol2003，22，5：	1
9	Basal expression of the multidrug resistance gene 1 (MDR-1) is associated with the TT genotype at the polymorphic site C3435T in mammary and ovarian carcinoma cell lines显示文摘	Kafka A Grundmann R	2002	Cancer Lett2002，185，：	1
10	HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium 显示文摘	Nazli A Kafka J K Ferreira V H	2013	J Immnnol2013，191，8：	1
11	Coronary bypass graft fate and patient outcome:angiographic follow-up of 5065 grafts related to survival and reoperation in 1388 patients during 25 years显示文摘	Fitzgibbon G M Kafka H P Leach A J	1996	J Am Coll Cardiol1996，28，3：	1
12	HIV-1 gpl20 induces TLR2- and TLR4- mediated innate immune activation in human female genital epithelium显示文摘	Nazli A Kafka J K Ferreira V H Anipindi V Muel- ler K Osborne B J Dizzell S Chauvin S Mian M F Ouellet M Tremblay M J Mossman K L Ashkar A A Kovacs C Bowdish D M Snider D P Kaul R Kaushic C	2013	J Immunol2013，191，8：	1
13	Coronary bypass graft fate and patient outcome: angiographic follow-up of 5065 grafts related to survival and reoperation in 1388 patients during 25 years显示文摘	FITZGIBBON G M KAFKA H P LEACH A J	1996	J Am Coll Cardiol1996，28，3：	1
14	Epithelial to mesenchymal transition: possible role in meningiomas 显示文摘	Peeina-Slaus N Cicvara-Pecina T Kafka A	2012	Front Biosci (Elite Ed)2012，4，：	1
15	Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer显示文摘	Kafka A Saner G Jaeger C	2003	Int J Oncol2003，22，5：	1
16	Effect of high doses of magnesium on converting ibutilide to a safe and more effective agent显示文摘	Patsilinakos S Christou A Kafkas N		0，，05：	1
17	Conversion efficacy of intravenous ibutilide compared with intravenous amiodarone in patients with recent-onset atrial fibrillation and atrial flutter 显示文摘	Kafkas N V Patsilinakos S P Mertzanos G A	2007	Int J Cardiol2007，118，3：	1
18	Analysis of sugars, organic acids and vitamin C contents of blackberry genotypes from Turkey显示文摘	Kafka E Kosar M Turemis N et a	2013	Food Chemistry2013，97，4：	1
19	Coronary bypass graft fate and patient outcome: angiographic follow-up of 5,065 grafts related to survival and reoperation in 1,388 pa- tients during 25 years 显示文摘	FITZGIBBON GM KAFKA HP LEACH A J	1996	J Am Coil Cardiol1996，28，：	1
20	Effect of high doses of magnesium on converting ibutilide to a safe and more effective agent 显示文摘	Patsilinakos S Christou A Kafkas N	2010	Am J Cardiol2010，106，67：	1

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