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| 1 | Molecular characterization of antimicrobial multi-drug resistance in non-typhoidal Salmonellae from chicken and clam in Mangalore, India显示文摘Salmonella enterica has been documented as one of the leading causes of salmonellosis throughout the world and is most commonly associated with the consumption of contaminated food products. Thus, this research was aimed at studying the antimicrobial susceptibility pattern and detection of quinolone resistance in Salmonella spp isolated from food of animal origin. Thirty-six Salmonella isolates comprising 8 from poultry and 28 from seafood(clams) were identified, serotyped and characterized for their antimicrobial susceptibility against 10 different antibiotics. Plasmid DNA was isolated from all the isolates by alkaline lysis, quinolone resistant non-typhoidal S. Weltevreden were examined for mutation in the DNA gyrase coding gene. Among the 36 Salmonella isolates, 20 were S. weltevreden(8 from poultry and 12 from seafood) and 16 were S. Typhimurium(from seafood). All the isolates showed multiple resistance to nalidixic acid, tetracycline, co-trimoxazole and nitrofurantoin, but, interestingly, the isolates were 100% susceptible to ampicillin, chloramphenicol and gentamicin. Resistant isolates from the study carried the genes responsible for resistance to respective antibiotics. The strain S130 isolated in the study showed single point mutation,Asp87Gly, at position 87 in quinolone resistance determining region. It revealed mutation in quinolone resistance determining region as a cause for quinolone resistance in non-typhoidal Salmonellae. The occurrence of genes accountable for plasmid mediated resistance to quinolones(viz., qnrA, qnrB and qnrS) in plasmid of non-typhoidal Salmonellae isolates provides evidence for plasmid mediated quinolone resistance. | Yemisi Olukemi Adesiji Santhosh Kogaluru Shivakumaraswamy Vijaya Kumar Deekshit Girisha Shivani Kallappa Indrani Karunasagar | 2018 | The Journal of Biomedical Research2018，32，3： | 2 |
| 2 | An Efficient and Eco-Friendly Tungstate Promoted Zirconia(WOx/ZrO2) Solid Acid Catalyst for the Synthesis of 2-ArylBenzimidazoles显示文摘 | Ramya V Shinagalapur Kallappa M | 2010 | Catal Lett2010，，137： | 1 |
| 3 | Distillery wastewater treatment by the membrane - based nanofiltration and reverse osmosis processes 显示文摘 | Sanna Kotrappanavar Nataraj Kallappa M Hosamani Tejraj M Aminabhavi | 2006 | Water Research2006，40，： | 1 |
| 4 | Life extending control of fossil fuel power plants显示文摘 | P Kallappa Michael Holmes Asok Ray | 1997 | Automatics1997，33，6： | 1 |
| 5 | Fuzzy wide-range control of fossil power plants for life extending and robust performance显示文摘 | P Kallappa Asok Ray | 2000 | Automatics2000，36，1： | 1 |
| 6 | 显示文摘 | Sanna K N Kallappa M H Tejraj M A | 2006 | Water Research2006，40，： | 1 |
| 7 | Comparison of topical anti-fungal agents sertaconazole and clotrimazole in the treatment of tinea corporis-An observational study显示文摘 | Shivamurthy RP Reddy SG Kallappa R | 2014 | J Clin Diagn Res2014，8，9： | 1 |
| 8 | Micropropagation of Dendrobium nobile from shoot tip sections显示文摘 | MALABADI R B MULGUND G S KALLAPPA N | | 0，，： | 1 |
| 9 | Fuzzy wide-range control of fos- sil power plants for life extension and robust per- formance 显示文摘 | Kallappa P Ray A | 2000 | Automatica2000，36，1： | 1 |
| 10 | Distillery wastewater treatment by the membrane-based nanofiltration and reverse osmosis processes显示文摘 | Sanna K Nataraj Kallappa M Hosamani Tejraj M Aminabhavi | 2006 | Water Research2006，40，： | 1 |
| 11 | Micropropagation of Dendrobium nobile from shoot tip sections显示文摘 | MALABADI R B MULGUND G S KALLAPPA N | 2005 | J Plant Physiol2005，162，： | 1 |
| 12 | Distillery wastewater treatment by the mem- brane-based nanofiltration and reverse osmosis processes 显示文摘 | Sanna Kotrappanavar Nataraj Kallappa M Hosamani Tejraj M Aminabbavi | 2006 | Water Research2006，40，12： | 1 |
| 13 | Micmpropagation of Dendrobium nobile from shoot tip sections显示文摘 | MALABADI R B MULGUND G S KALLAPPA N | 2005 | Journal of Plant Physiology2005，162，： | 1 |
| 14 | Intact giant ab- dominal aortic aneurysm due to Takayasu arteritis显示文摘 | Kallappa PS Mandjiny N Kavumkal RB | 2013 | Ann Vasc Surg2013，27，5： | 1 |
| 15 | A fuzzy logic based approach for modeling quality and reliability related customer satisfaction in the automotive domain显示文摘 | Rahul Chougule Kallappa Pattada | 2013 | Expert Systems with Applications2013，2，： | 1 |
| 16 | Fuzzy wide-range control of fossil power plants for life extension and robust performance显示文摘 | P Kallappa Asok Ray | 2000 | Automatica2000，36，1： | 1 |
| 17 | Life-extending control of fossil fuel power plants显示文摘 | P Kallappa Michael S Holmes Asok Ray | 1997 | Automafice1997，33，6： | 1 |
| 18 | Physicochemical properties,antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids显示文摘Objective:To study physicochemical properties,antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids.Methods:The substituted 4-bromomethyl coumarins were synthesized in first step by the cyclization.Then the reaction of substituted coumarins(a-e)with potassium O-ethyl/methyl carbonodithioate(1)by using absolute ethanol as solvent,afforded coumarin-carbonodithioate(1a-1j)derivatives under microwave irradiation and the conventional method.The spectroscopic analysis was used for the characterization of coumarin derivatives.The title(1a-1j)compounds were confirmed by spectroscopic methods.Antioxidant property was evaluated by using DPPH free radical-scavenging ability assay method and anti-inflammatory activity was evaluated by protein denaturation procedure using diclofenac sodium as a standard.Drug-likeness.In-silico toxicity was predicted with LD_(50)value and bioactivity score was also calculated for all the compounds.Results:All coumarin(1a-1j)compounds exhibited promisingin-vitro antioxidant and anti-inflammatory properties in comparison to standard drugs.All tested compounds were used for evaluating their physicochemical properties as set by Lipinski rule.It was observed that the synthesized compounds followed rule of five,indicating more'drug-like'nature.Conclusions:All the screened coumarin-carbonodithioates display promising in vitro antioxidant and antiinflammatory activities.From the physicochemical properties of coumarin derivatives,it is found that none of the compounds violate the Lipinski rule and they fall well in the range of rule of five.It is concluded that the coumarin-carbonodithioate hybrids act with more'drug-like'nature. | Suresh S.Kumbar Kallappa M.Hosamani Arun K.Shettar | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，4： | 0 |
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