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| 1 | Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication显示文摘AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed eradication.METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication.RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. | Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si | 2018 | World Journal of Gastroenterology2018，24，40： | 18 |
| 2 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 3 | MUC4阴性的硬化性上皮样纤维肉瘤亚型可检出伴高频性YAP1和KMT2A基因重排显示文摘硬化性上皮样纤维肉瘤是一种侵袭性软组织肉瘤,其组织学特征为在致密硬化的胶原间质内散在上皮样细胞,免疫组化标志物MUC4常阳性,通常存在包括EWSR1在内的基因融合。由于与低度恶性纤维黏液样肉瘤在组织形态和遗传学特征方面有一些重叠,推测两者发病机制可能存在关联。实验显示有一小部分硬化性上皮样纤维肉瘤免疫组化MUC4阴性,且缺乏典型EWSR1/FUS基因重排。作者最初发现3例为MUC4阴性及EWSR1/FUS基因重排阴性的硬化性上皮样纤维肉瘤,经靶向RNA测序检测发现存在YAP1-KMT2A融合。 | Kao Y C Lee J C Zhang L 王婷(摘译) 余英豪(审校) | 2020 | 临床与实验病理学杂志2020，36，8： | 2 |
| 4 | Ca^2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements 显示文摘 | Kao J P Tsien R Y | 1988 | Biophys J1988，53，4： | 1 |
| 5 | In vitro generation of islets in long term cultures of pluripotent stem cells from adult mouse pancreas显示文摘 | Tchernev V Kao K J | 1997 | Horm Metab Res1997，29，6： | 1 |
| 6 | Lax-Friedrichs sweeping scheme for static Hamihon-Jacobi equations 显示文摘 | C Y Kao S Osher J Qian | 2004 | Journal of Computational Physics2004，196，1： | 1 |
| 7 | Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models显示文摘 | Sheu MY Fowler AJ Kao J | 2002 | J Invest Dermatol2002，118，1： | 1 |
| 8 | Asian-Pacific consensus statement on the management of chronic hepatitis B:a 2008update显示文摘 | Liaw Y F Leung N Kao J H | 2008 | Hepatol Int2008，2，3： | 1 |
| 9 | Results of intraopera- five mitomycin C application in dacryocystorhinostomy 显示文摘 | LIAO S L KAO SC TSENG J H | 2000 | Br J Ophthalmol2000，84，8： | 1 |
| 10 | Cellular eardiomyoplasty:Myocardial regeneration with satellite cell implantation显示文摘 | Chiu R C J Zibaitis A Kao R L | 1995 | Ann Thorac Surg1995，60，： | 1 |
| 11 | Phase 1 study of concurrent sunitinib and image guided radiotherapy followed by maintenance sunitinib for patients with oligometastases: acute toxicity and pre- liminary response显示文摘 | KAO J PACKER S VU H L | 2009 | Cancer2009，115，15： | 1 |
| 12 | Depression, quality oflife, andglycemic control in individuals with type 2 diabetes 显示文摘 | Lee H J Chapa D Kao CW | 2009 | J Am Acad Nurse Pratt2009，21，4： | 1 |
| 13 | Interfacial reactions and compound forma-tion of Sn-Ag-Cu Solders by mechanical alloying on electroless Ni-P/Cu under bump metallization显示文摘 | KAO S T DUH J G | 2005 | Journal of Electronic Materi-als2005，34，8： | 1 |
| 14 | Treatment of distal femoral fracture by minimally invasive percutaneous plate osteosynthesis:comparison between the dynamic condylar screw and the less invasive stabilization system显示文摘 | Kao F C Tu Y K Su J Y | | 0，，07： | 1 |
| 15 | 查看详情显示文摘 | Hsu J P Kao C Y Tseng S J Chen C J | | 0，，： | 1 |
| 16 | Moving the arms to activate the legs显示文摘 | Ferris D P Huang H J Kao P C | 2006 | Exerc Sport Sci Rev2006，34，3： | 1 |
| 17 | Mierocolonies of the bacterium asso- ciated with ratoon stunting disease found in sugarcane xylem matrix 显示文摘 | KAO J DAMANN K E J | 1978 | Phytopathology1978，68，： | 1 |
| 18 | MDA5plays a crucial role in enterovirus 71RNA-mediated IRF3 activation显示文摘 | Kuo R L Kao L T Lin S J Wang R Y Shih S R | 2013 | PLoS One2013，8，63： | 1 |
| 19 | On the estimation and inference of a panel cointegration model with cross-sectional depen dence显示文摘 | BAI J KAO C | 2006 | Contributions to Economic Analysis2006，274，： | 1 |
| 20 | NPS model parameter uncertainty analysis for an off-stream reservoir 显示文摘 | Kao J J Hong H J | 1996 | Water Resources Bulletin1996，32，5： | 1 |
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