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| 1 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 2 | 查看详情显示文摘 | Manzoni M R Zabawa T P Kasi D | | 0，，： | 1 |
| 3 | Inhibition of src family kinase by a combinatorial action of 5}-AMP and smal heat shock proteins,identified from the adult heat显示文摘 | Kasi VS Kuppuswamy D | 1999 | Mol Cel Biol1999，19，10： | 1 |
| 4 | Thermal Analysis of Mi- crowave Assisted Bonding of Poly( Methyl Methacrylate)Substrates in Microfluidic Devices显示文摘 | Kasi B M Mohammad R H Prashanta D | 2013 | International Journal of Heat and Mass Transfer2013，58，12： | 1 |
| 5 | Inhibition of src family kinase by a combinatorial action of 5′-AMP and small heat shock proteins, identified from the adult heat显示文摘 | Kasi VS Kuppuswamy D | 1999 | Mol Cell Biol1999，19，10： | 1 |
| 6 | Effect of cisplatin chemotherapy on otoacoustic emission:the development of an objective screening protocol显示文摘 | Bradford D Kasi S Thomas J | 1999 | Otolaryngol Head Neck Surg1999，121，： | 1 |
| 7 | Effect of cisplatin chemotherapy on otoacoustic emission:the development of an objective screening protocol显示文摘 | Bradford D Kasi S Thomas J | 1999 | Otolaryngol Head Neck Surg1999，121，： | 1 |
| 8 | Effect of cisplatin chemotherapy on otoacoustic emission:the development of an objective screening protocol显示文摘 | Bradford D Kasi S Thomas J | 1999 | Otolaryngol Head Neck Surg1999，121，： | 1 |
| 9 | Palladium(Ⅱ)-catalyzed intramolecularaminobromination and aminochlorination of olefins显示文摘 | MANZONI M R ZABAWAT P KASI D | 2004 | Organometallics2004，23，23： | 1 |
| 10 | Do- simetry and toxicity of samarium-153-EDTMP administered for bone pain due to skeletal metas- tases显示文摘 | Bayouth J E Maccy D J Kasi L P | 1994 | J Nucl Med1994，35，1： | 1 |
| 11 | Copper(11)acetate promoted intramolecular diamination of unactivatedolefins显示文摘 | ZABAWA T P KASI D CHEMLER S R | 2005 | J Am Chem Soc2005，127，11： | 1 |
| 12 | Determination of dissociation constant of phosphinate group in phosphinic pseudopeptides by capillary zone electrophoresis 显示文摘 | KOVAL D KASI CKA V JIRA CEK J | 2002 | J Chromatogr B2002，770，12： | 1 |
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