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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Microbial community changes in biological phosphate-removal systems on altering sludge phosphorus content显示文摘 | Katrina D L Nakamura K | 2000 | Environ Microbio2000，14，6： | 1 |
| 3 | Nucleolin is regulated both at the level of transcription and translation显示文摘 | Katrina B Gavin B Pete K | | 0，，03： | 1 |
| 4 | Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectic in human adipose tis- sue by weight change, leptin, insulin, and glucose 显示文摘 | Katrina K Steve W Bee T | 2009 | Diabetes2009，58，18： | 1 |
| 5 | In the dark: Young men' s stories of sexual initiation in the absence of relevant sexual health information 显示文摘 | Katrina K William B George W | 2010 | Health Education & Behavior2010，37，2： | 1 |
| 6 | Racial/ethnic differences in hospital use and cost among a statewide population of children with Down syndrome显示文摘 | Taletha MD Milton K Katrina P | 2013 | Res Dev Disabil2013，34，10： | 1 |
| 7 | Hypoxia-inducible factor-1-dependent regulation of the multidrug resistence(MDR1)gene显示文摘 | Katrina MC Timothy JW Jrn K | 2002 | Cancer Res2002，62，： | 1 |
| 8 | Microbial community changes in biological phosphate-removal systems on altering sludge phosphorus content显示文摘 | Liu W T Katrina D Nakamura K 2000 | 2000 | Environ Microbio2000，146，： | 1 |
| 9 | Federal competition and economic growth 显示文摘 | John W H Katrina K | 2013 | Journal of Public Economics2013，97，1： | 1 |
| 10 | Regulation of the fibrosis andangiogenesis promoter SPARC/osteonectie in human adipose tissue by weight change, leptin, insulin, and glucose 显示文摘 | Katrina K Steve W Bee T | 2009 | Diabetes2009，58，18： | 1 |
| 11 | Use and perceptions of the lnternet for sexual information and partners: A study of young men who have sex with men显示文摘 | Katrina K Julie C Bryce M | 2011 | Arch Sex Behav2011，40，4： | 1 |
| 12 | Racial/ethnic differ-ences in hospital use and cost among a statewide population ofchildren with Down syndrome显示文摘 | Taletha MD Milton K Katrina P | 2013 | Res Dev Disabil2013，34，10： | 1 |
| 13 | Regulation of the fibrosis and angoigenes is promoter SPARC/osteonectic in human adipose tissue by weight change,leptin,insulin,and glucose显示文摘 | Katrina K Steve W Bee T | 2009 | Diabetes2009，58，18： | 1 |
| 14 | Rosiglitazone treatment alleviates inflammation and imp roves liver function in overweight women with polycystic ovary syndrome:a randomized placebo-controlled study显示文摘 | Rautio K T Katrina M P Laure C T | 2007 | Fertil Steril2007，87，1： | 1 |
| 15 | Mechanisms of IL-2-dependent maintenance of functional regulatory T cells显示文摘 | LUKE B HANS D KATRINA K | 2010 | J Immunol2010，185，： | 1 |
| 16 | Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectie in human adi pose tissue by weight change, leptin, insulin, and glucose 显示文摘 | Katrina K Steve W Bee T | 2009 | Diabetes2009，58，18： | 1 |
| 17 | Evaluation of the Impact of the Natural Forest Protection Program on Rural Household Livelihoods显示文摘 | KATRINA M ANDREAS K TIMOTHY M | 2010 | Environmental Management2010，45，3： | 1 |
| 18 | Recycled Concrete Aggregates: A Review 显示文摘 | Katrina M N Thomas H K K | 2013 | International Journal of concrete structures and materials2013，，： | 1 |
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