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| 1 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Hepatic and extrahepatic malignancies in primary sclerosing cholangitis显示文摘 | Annika Bergquist Anders Ekbom Rolf Olsson Dan Kornfeldt Lars L??f ?ke Danielsson Rolf Hultcrantz Stefan Lindgren Hanne Prytz Hanna Sandberg-Gertzén Sven Almer Fredrik Granath Ulrika Broomé | 2002 | Journal of Hepatology2002，，3： | 2 |
| 4 | Preparation and photocatalytic activity of dysprosium doped tungsten trioxide nanoparticles 显示文摘 | Liu H J Peng T Y Ke D N | 2007 | Materials Chemistry and Physics2007，104，23： | 1 |
| 5 | PTEN-mediated Akt/13-cate- nin/Foxol signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury 显示文摘 | Kamo N Ke B Busuttil RW | 2013 | Hepatology2013，57，1： | 1 |
| 6 | Orally disintegrating selegiline in Parkinson patients with dopamine ago-nist-related adverse effects显示文摘 | Lyons KE Friedman JH Hermanowicz N | 2010 | Clin Neuropharmaeol2010，33，1： | 1 |
| 7 | Preparation and photocatalytic activity of WO3/TiO2 nanocomposite particles 显示文摘 | Ke D N Liu H J Peng T Y | 2008 | Materials Letters2008，62，3： | 1 |
| 8 | Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4,joint macrophages,granulocyte-macrophage colony-stimulating factor,interleukin-6,and leukemia inhibitory factor显示文摘 | Lawlor KE Wong PK Campbell IK van Rooijen N Wicks IP | 2005 | Arthritis Rheum2005，52，12： | 1 |
| 9 | Laparoscopic nissen fundoplication combined with posterior gastropexy in surgical treatment of gerd显示文摘 | Tsimogiannis KE Pappas-Gogos GK Benetatos N | 2010 | Surg Endosc2010，24，6： | 1 |
| 10 | FIEN-mediated Akt/15-Catenin/ Foxol signaling regulates innate immune responses in mouse liver is- chemia/reperfusion injury 显示文摘 | Kamo N Ke B Busuttil RW | 2013 | Hepatology2013，57，1： | 1 |
| 11 | Fully frmctional hair follicle regeneration through the rearrangement of stem cells and their niches 显示文摘 | Toyoshima KE Asakawa K Ishibashi N | 2012 | Nat Cmnmun2012，3，： | 1 |
| 12 | CdS/Regenerated Cellulose Nanocomposite Films for Highly Efficient Photocatalytic H2 Production under Visible Light Irradiation显示文摘 | Ke D N Liu S L Dai K | 2009 | J Phys Chem C2009，113，16： | 1 |
| 13 | Effect of Oxiplex films(PEO/CMC) on adhesion formation and reformation in rabbit models and on peritoneal infection in a rat model显示文摘 | Rodgcrs KE Schwartz HE Roda N | 2000 | Fertil Steril2000，73，4： | 1 |
| 14 | Cell-cycle -dependent regulation of DNA replication and its relevance to cancer pathology显示文摘 | Tachibana KE Gonzalez MA Coleman N | 2005 | J Pathol2005，205，2： | 1 |
| 15 | The economic burden of major adult visual disorders in the United States显示文摘 | Rein DB Zhang P Wirth KE Lee PP Hoerger T J McCall N | 2005 | Arch Ophthalmol2005，124，12： | 1 |
| 16 | Quantitative analysis of cerebral vasculopathy in patients with Fabry disease 显示文摘 | Crutchfield KE Patronas N J Dambrosia JM | 1998 | Neurology1998，50，6： | 1 |
| 17 | Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation[J[显示文摘 | Poole KE van Bezooijen RL Loveridge N | | 0，，13： | 1 |
| 18 | Serum levels of sex hormones and breast cancer risk in premenopausal women: a case-control study 显示文摘 | Sturgeon SR Potischman N Malone KE | 2004 | Cancer Causes Control2004，15，1： | 1 |
| 19 | Synthesis, characterization of CdS/Rectorite nanocomposites and its photoeata lytic activity显示文摘 | Xiao J R Peng T Y Ke D N | 2007 | Phys Chem Miner2007，34，4： | 1 |
| 20 | Injecting equipment shar-ing in Russian drug injecting dyads显示文摘 | Gyarmathy VA Li N Tobin KE | 2010 | AIDS Behav2010，14，1： | 1 |
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