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| 1 | 长春市儿童医院1998~2001年婴幼儿杯状病毒腹泻流行病学研究显示文摘人类杯状病毒(humancalicivirus,HuCV)是引起儿童和成人非菌性胃肠炎的主要病原之一。为了掌握HuCV在我国的流行情况,1998年7月至2001年6月,从长春市儿童医院2343例5岁以下腹泻患儿中共收集粪便标本1264份,其中1056份来自2135例住院患儿。对轮状病毒检测为阴性的588份标本,经多价酶免疫试验(EIA)和两组引物反转录-聚合酶链反应(RT-PCR)检测HuCV,202份为阳性,其中住院患儿标本178份,HuCV检出率为16 9%。HuCV腹泻以2岁以下儿童为主(占96%),流行高峰季节为11月至次年3月。选择17株HuCV进行分子鉴定,15株属GⅡ 4群,1株属GⅡ 3群,另1株属GⅠ 2群,表明GⅡ 4群HuCV是我国流行的优势株。根据HuCV住院患儿的监测资料初步估计,HuCV腹泻住院率约为0 5‰~2 4‰。讨论了长春地区HuCV的流行趋势和疾病负担。以上结果为我国HuCV腹泻的预防和控制提供了科学依据。 | 谢华萍 方肇寅 王光 孙利炜 吕红霞 Zhong WM Tai JH 林思恩 童志礼 章青 Glass RI Jiang X | 2002 | 病毒学报2002，18，4： | 75 |
| 2 | Induction of apoptosis by arsenic trioxide and hydroxycamptothecin in gastric cancer cells in vitro显示文摘AIM To study the effects of arsenic trioxide andHCPT on different degrees of differentiated gastriccancer cells(SGC-7901,MKN-45,MKN-28)withrespect to both cytotoxicity and induction ofapoptosis in vitro.METHODS The cytotoxicity of As2O3 and HCPTon gastric cancer cells was determined by MTTassay.Morphologic changes of apoptosis ofgastric cancer cells were observed by lightmicroscopy and transmission electron microscopy.Apoptosis and cell cycle changes of gastric cancercells induced by HCPT and As2O3 were investigatedby TUNEL method and flow cytometry.RESULTS As2O3 and HCPT had remarkablecytotoxic effects on different degrees ofdifferentiated gastric cancer cells.The IC50ofAs2O3 on well differentiated gastric cancer cellMKN-28,moderately differentiated gastric cancercell SGC-7901,and poorly differentiated gastriccancer cell MKN-28 were 8.91 μmol/L,10.57μmol/L,and 11.65 μmol/L,respectively.The IC50of HCPT on MKN-28,SGC-7901,and MKN-45 were9.35 mg/L,10.21 mg/L,and 12.63 mg/Lrespectively after 48 h treatment.After 12 h ofexposure to both drugs,gastric cancer cellsexhibited morphologic features of apoptosis,including cell shrinkage,nuclear condensation, and formation of apoptotic bodies.A typicalsubdiploid peak before G0/G1 phase was observedby flow cytometry.The apoptotic rates of SGC-7901,MKN-45,and MKN-28 were 13.84%,22.52%,and 9.68%,respectively after 48 hexposure to 10 μmol/L As2O3.The apoptotic ratesof SGC-7901,MKN-45,and MKN-28 were 21.88%,12.35%,and 30.26%,respectively after 48 hexposure to 10 mg/L HCPT.The apoptotic indicewere 7%-15% as assessed by TUNEL method.The effect of As2O3 on SGC-7901 showedremarkable cell cycle specificity,which inducedcell death in G1 phase,and blocked G2/M phase.HCPT also showed a remarkable cell cyclespecificity,by inducing cell death and apoptosis inG1 phase and arrest of proliferation at S phase.CONCLUSION As2O3 and HCPT exhibitsignificant cytotoxicity on gastric cancer cells byinduction of apoptosis.As2O3 and HCPT mighthave a promising prospect in the treatment ofgastric cancer,which needs to be further studied. | Tu SP Zhong J Tan JH Jiang XH Qiao MM Wu YX Jiang SH | 2000 | World Journal of Gastroenterology2000，6，4： | 43 |
| 3 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 4 | Pharmacokinetics of 9-nitro-20(S) -camptothecin in rats 显示文摘 | Zhong DF Li K Xu JH | 2003 | Acta Pharmacol Sin2003，24，3： | 2 |
| 5 | An evaluation of the therapeutic effect and the cost of the combined use of diethylstilbestrol and prazosin in treating hyperaplasia prostate显示文摘 | Zhong WD Ling JH Ruan YD Feng YB Zhou FN | 2001 | Chin J Urol (中华泌尿外科杂志)2001，22，1： | 1 |
| 6 | 显示文摘 | Song XY Zhong JH Wang X | 2004 | J Neurosci2004，24，2： | 1 |
| 7 | MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression显示文摘 | Zhong XY Yu JH Zhang WG | 2012 | Gene2012，493，1： | 1 |
| 8 | Pharmacokinetics of 9-nitro-20(S)-camptothecin in rats 显示文摘 | Zhong DF Li K Xu JH | 2003 | Acta Pharmacol Sin2003，24，3： | 1 |
| 9 | Ameliorative effect of berberine on renal damage in rats with diabetes induced by highfat diet and streptozotocin显示文摘 | Wu D Wen W Qi CL Zhao RX LüJH Zhong CY | 2012 | Phytomedicine2012，19，89： | 1 |
| 10 | Management of primary angle-closure glaucoma by phacoemul-sification with foldable posterior chamber intraocular lens implantation显示文摘 | Wu JH Liu L Zhao SH Zhong M | 2008 | Zhejiang Da xue xue Bao Yi xue Ban2008，37，4： | 1 |
| 11 | The association between non-Hodgkin lymphoma and methylation of p73显示文摘 | Pei JH Luo SQ Zhong Y | | 0，，06： | 1 |
| 12 | Impact of diabetes mellittls on the prognosis of patients with hepatocel]ular carcinoma after cur- ative hepateetomy显示文摘 | Wang YY Huang S Zhong JH | 2014 | PLoS One2014，9，13： | 1 |
| 13 | Lamivudine with or without adefovir dipivoxil for postoperative hepatocellular carcinoma显示文摘 | Zhong JH Li LQ Wu LC | 2011 | Cochrane Database Syst Rev2011，12，00： | 1 |
| 14 | MDA-9/syntenin promotes human brain glioma migration through focal adhesion kinase(FAK)-JNK and FAK-AKT signaling显示文摘 | Zhong D Ran JH Tang WY | 2012 | Asian Pac J Cancer Prev2012，13，6： | 1 |
| 15 | Clinical and hiolngical sig- nificance of CdklO in hepatoeellular carcinoma 显示文摘 | Zhong XY Xn XX Yu JH et td | 2012 | Gene2012，498，： | 1 |
| 16 | A study ofthe effect of plug-holing and boundary layer separationon natural ventilation with vertical shaft in urban roadtunnel fires 显示文摘 | Ji J Gao ZH Fan CG Zhong W Sun JH | 2012 | International Journal of Heat MassTransfer2012，21，21： | 1 |
| 17 | Clinical and prognostic significance of miR-155 and miR-146a expression levels in formalin-fixed/paraffin-embedded tissue of patients with diffuse large B-cell lymphoma显示文摘 | Zhong H Xu L Zhong JH | 2012 | Exp Ther Med2012，3，5： | 1 |
| 18 | Enhanced sensitivity to molecular diffusion with intermolecular double-quantum coherences: implications and potential applications显示文摘 | Zhong JH Chen Z Kwok E | 2001 | Magn Reson Imaging2001，19，1： | 1 |
| 19 | Suppression of p75NTR does not promote regeneration of injured spinal cord in mice显示文摘 | Song XY Zhong JH Wang X | 2004 | J Neurosci2004，24，2： | 1 |
| 20 | Optimization of blood oxygenation level-dependent sensitivity in magnetic resonance imaging using intermolecular double-quantum coherence显示文摘 | Zhong JH Chen Z Kwok WE | 2002 | J Magn Reson Imaging2002，16，6： | 1 |
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