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| 1 | Impact of a nationwide training program for neonatal resuscitation in China显示文摘 | XU Tao WANG Hui-shan YE Hong-mao YU Ren-jie HUANG Xing-hua WANG Dan-hua Wang Li-xin FENG Qi GONG Li-min MA Yi William Keenan Susan Niermeyer | 2012 | Chinese Medical Journal2012，，8： | 13 |
| 2 | 定量CT测量动物肝脏脂肪含量的实验研究显示文摘目的:以Soxhlet化学萃取法的测量结果为参考标准,探讨定量CT(QCT)对离体动物肝脏标本脂肪含量测量的准确性。方法:选取5块猪肝、5块鹅肝和10块鸭肝,分别使用QCT和Soxhlet化学萃取法测量每个样本的脂肪含量。对QCT测得的肝脏脂肪含量(Fat%Q)和Soxhlet化学萃取法测得的肝脏脂肪含量(Fat%S)进行比较,并使用线性回归分析研究Fat%Q与Fat%S之间的关系。结果:Soxhlet化学萃取法测得的猪肝、鸭肝和鹅肝的脂肪含量分别为0.5%~2.3%、7.2%~21.0%和35.0%~52.6%,QCT测得的肝脏脂肪含量低于Soxhlet化学萃取法,但两种方法的测量结果差异无统计学意义(P=0.052)。两种方法的测量结果高度相关(r=0.962,P<0.001),Fat%S可以通过线性方程Fat%S=0.74,Fat%Q+7.272(r2=0.965,P<0.001)进行预测。结论:以化学Soxhlet萃取法作为验证参考标准,使用常规CT和QCT体模能够准确测量离体动物肝脏样本的脂肪含量。 | 徐黎 端木羊羊 张勇 Keenan Brown 张曼玲 程晓光 | 2017 | 放射学实践2017，32，5： | 13 |
| 3 | POAMA海气耦合模式对2003和2004年南海夏季风预报能力的评估显示文摘运用澳大利亚大气海洋耦合预报模式(Predictive Ocean Atmosphere Model for Australia,POAMA)的输出结果,采用泰勒图与分类统计分析方法,评估了该模式对2003和2004年南海夏季风的爆发和演变进行实时预报的能力。通过对泰勒图的分析发现,随着预报初始时间越来越接近实际的季风爆发时间,模式预报南海夏季风爆发和演变的能力越来越强。当提前1—30d预报南海夏季风时,模式能够很好地预报风场、射出长波辐射OLR(Outgoing Longwave Radiation)和降水场的空间分布,其中对风场的预报最好。通过对季风爆发指数和分类统计的分析,定量分析了模式预报南海夏季风爆发的能力,结果表明该模式对南海夏季风爆发时间有一定的预报能力,其最大预报时限可以提前10—15d左右,这与目前中期预报的上限(2周)是一致的。 | 柳艳菊 丁一汇 Keenan T 孙爱东 | 2005 | 热带海洋学报2005，24，5： | 10 |
| 4 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 5 | To mask or not to mask:Modeling the potential for face mask use by the general public to curtail the COVID-19 pandemic显示文摘Face mask use by the general public for limiting the spread of the COVID-19 pandemic is controversial,though increasingly recommended,and the potential of this intervention is not well understood.We develop a compartmental model for assessing the communitywide impact of mask use by the general,asymptomatic public,a portion of which may be asymptomatically infectious.Model simulations,using data relevant to COVID-19 dynamics in the US states of New York and Washington,suggest that broad adoption of even relatively ineffective face masks may meaningfully reduce community transmission of COVID-19 and decrease peak hospitalizations and deaths.Moreover,mask use decreases the effective transmission rate in nearly linear proportion to the product of mask effectiveness(as a fraction of potentially infectious contacts blocked)and coverage rate(as a fraction of the general population),while the impact on epidemiologic outcomes(death,hospitalizations)is highly nonlinear,indicating masks could synergize with other nonpharmaceutical measures.Notably,masks are found to be useful with respect to both preventing illness in healthy persons and preventing asymptomatic transmission.Hypothetical mask adoption scenarios,for Washington and New York state,suggest that immediate near universal(80%)adoption of moderately(50%)effective masks could prevent on the order of 17e45%of projected deaths over two months in New York,while decreasing the peak daily death rate by 34e58%,absent other changes in epidemic dynamics.Even very weak masks(20%effective)can still be useful if the underlying transmission rate is relatively low or decreasing:InWashington,where baseline transmission is much less intense,80%adoption of such masks could reduce mortality by 24e65%(and peak deaths 15e69%),compared to 2e9%mortality reduction in New York(peak death reduction 9e18%).Our results suggest use of face masks by the general public is potentially of high value in curtailing community transmission and the burden of the pandemic.The community-wide benefits are likely to be greatest when face masks are used in conjunction with other non-pharmaceutical practices(such as social-distancing),and when adoption is nearly universal(nation-wide)and compliance is high. | Steffen E.Eikenberry Marina Mancuso Enahoro Iboi Tin Phan Keenan Eikenberry Yang Kuang Eric Kostelich Abba B.Gumel | 2020 | Infectious Disease Modelling2020，5，1： | 8 |
| 6 | Heart Failure-Related Hospitalization in the U.S., 1979 to 2004显示文摘 | Jing Fang George A. Mensah Janet B. Croft Nora L. Keenan | 2008 | Journal of the American College of Cardiology2008，，6： | 3 |
| 7 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 8 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 9 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 10 | Erythropoietin crosses the blood-brainbarrier to protect against experimental brain injury显示文摘 | Brines ML Ghezzi P Keenan S | 2000 | Proc Natl Acad Sei U S A2000，97，10： | 1 |
| 11 | Ventilator-associated Pneumonia,Prevention,diagnosis, and therapy 显示文摘 | Keenan SP Heyland DK Jaeka M J | 2002 | Crit Care Clin2002，18，： | 1 |
| 12 | Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia显示文摘 | Dodek P Keenan S Cook D | 2004 | Ann Intern Med2004，141，4： | 1 |
| 13 | Infertility in the 1990, s; from basic investigation to advanced treatment 显示文摘 | ToLed O AA keenan D L | 1997 | J Med Assoc Ga1997，86，3： | 1 |
| 14 | Interindividual variability of the modulatoy effects of repetitive transcranial magnetic stimulation on cortical excitability显示文摘 | Maeda F Keenan IP Tormos IM | 2000 | Exp Brain Res2000，131，： | 1 |
| 15 | Thoracoscopic pancreatic denervation for pain control in irresectable pancreatic cancer显示文摘 | Worsey J Ferson PF Keenan RJ | 1993 | Br J Surg1993，80，： | 1 |
| 16 | Noninvasive posi- tive-pressure ventilation for postextubation respiratory distress: a randomized controlled trial显示文摘 | Keenan S P Powers C McCormack D G et aI | 2002 | JAMA2002，287，24： | 1 |
| 17 | , a randomized controlled trial 显示文摘 | Keenan SP Powers CE McCormack DG Noninvasive positive- pressure ventilation in patients with milder chronic obstructive pulmonary disease exacerbations | 2005 | RespirCare2005，50，5： | 1 |
| 18 | Integrated cardiac and vascular assessment in Takayasu arteritis by cardiovascular magnetic resonance显示文摘 | Keenan NG Mason JC Maceira A | 2009 | Arthritis Rheum2009，60，11： | 1 |
| 19 | More on propranolol for hemangiomas of infancy 显示文摘 | SIEGFRIED E C KEENAN W J AL-JUREID1NI S | 2008 | N Eng J Med2008，359，26： | 1 |
| 20 | Segmentalresection spares pulmonary function in patients with stageI lung cancer 显示文摘 | Keenan RJ Landreneau RJ Maley RH Jr | 2004 | Ann Thorac Surg2004，78，1： | 1 |
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