3篇
您的检索式：作者名="Kevin Houston"
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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Advances and horizons for artificial intelligence of endoscopic screening and surveillance of gastric and esophageal disease显示文摘The development of artificial intelligence in endoscopic assessment of the gastrointestinal tract has shown progressive enhancement in diagnostic acuity.This review discusses the expanding applications for gastric and esophageal diseases.The gastric section covers the utility of AI in detecting and characterizing gastric polyps and further explores prevention,detection,and classification of gastric cancer.The esophageal discussion highlights applications for use in screening and surveillance in Barrett's esophagus and in high-risk conditions for esophageal squamous cell carcinoma.Additionally,these discussions highlight applications for use in assessing eosinophilic esophagitis and future potential in assessing esophageal microbiome changes. | Byung Soo Yoo Kevin V Houston Steve M D'Souza Alsiddig Elmahdi Isaac Davis Ana Vilela Parth J Parekh David A Johnson | 2022 | Artificial Intelligence in Medical Imaging2022，3，3： | 0 |
| 3 | Artificial intelligence and colonoscopy − enhancements and improvements显示文摘Artificial intelligence is a technology that processes and analyzes information with reproducibility and accuracy.Its application in medicine,especially in the field of gastroenterology,has great potential to facilitate in diagnosis of various disease states.Currently,the role of artificial intelligence as it pertains to colonoscopy revolves around enhanced polyp detection and characterization.The aim of this article is to review the current and potential future applications of artificial intelligence for enhanced quality of detection for colorectal neoplasia. | Byung Soo Yoo Steve M D'Souza Kevin Houston Ankit Patel James Lau Alsiddig Elmahdi Parth J Parekh David Johnson | 2021 | Artificial Intelligence in Gastrointestinal Endoscopy2021，2，4： | 0 |
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