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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 3 | Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones 显示文摘 | KEN E MURAGLIA A CORSI A | 2000 | J Bi- omed Mater Res2000，49，3： | 1 |
| 4 | Global association of air pollution and heart failure: a systematic review and meta-analysis显示文摘 | Anoop SV Shah Jeremy P Langrish Harish Nair David A McAllister Amanda L Hunter Ken Donaldson David E Newby Nicholas L Mills | 2013 | The Lancet2013，，： | 1 |
| 5 | Minimal structures: From jazz improvisation to product innovation显示文摘 | KEN Kamoche Miguel Pina E Cunha | 2001 | Organization Studies2001，22，5： | 1 |
| 6 | Geochemistry of Crude Oils from Eastern Indonesia 显示文摘 | Ken E Peters Tom H Fraser Welly Amris | 1999 | AAPG Bulletin1999，83，12： | 1 |
| 7 | Flavonoid gene expression and UV photoprotection in transgenic and mutant Petunia leaves 显示文摘 | Ken G Rayan Ewald E Swinny Kenneth R Markham | 2002 | Phytochemistry2002，59，： | 1 |
| 8 | pharmacological properties of galenicai properations(XX) :Screening of natural products in Polyg- alae Radix 显示文摘 | Wang SS Saito Ken Owada E | 1995 | J Traditional Medicines1995，12，： | 1 |
| 9 | Multivariate morphometric analysis of the Apis cerana of China 显示文摘 | TAN Ken HEPBUM H R RADLOFF S E | 2008 | Apidologie2008，39，3： | 1 |
| 10 | Entrepreneurial skills assessment: an esploratory study显示文摘 | WILLIAM L SMITH KEN SCHALLENKAMP DOUG-LAS E EICHHOLZ | 2007 | International Journal of Management and Enterprise Development2007，4，2： | 1 |
| 11 | Twin-wire GMAW : Process Characteristics and Applications 显示文摘 | KEN M STEPHEN B GUNBIYI T E B O | 1999 | Welding Journal1999，78，05： | 1 |
| 12 | Flavonoids and UV Photoprotection in Arabidopsis Mutants显示文摘 | Ken G R Ewald E S Chris W | 2015 | Zeitschrift für Naturforschung C2015，56，9： | 1 |
| 13 | Tyrosine phosphorylation of HSP2 90 during mammalian sperm capacitation 显示文摘 | Heat h E Russel C Ait ken J | 2003 | Biol Reprod2003，69，： | 1 |
| 14 | Improved utilisation of renewable resources: New important derivatives of glycerol显示文摘 | Arno B Jens E Ken I | 2008 | Green Chemistry2008，10，： | 1 |
| 15 | 25-Hydroxyvitamin D levels and juvenile idiopathic arthritis: Is there an association with disease activity?显示文摘 | Pel a jo CF Lopez-Beni t e z JM Ken t DM et a l | 2012 | Rheumatol Int2012，32，12： | 1 |
| 16 | Spray Cooling Heat Transfer: Technology Overview and Assessment of Future Challenges for Micro-Gravity Application 显示文摘 | Silk E A Jungho K Ken K | 2008 | Energy Converse Manage2008，49，3： | 1 |
| 17 | Global association of air pollution and heart failure: a systematic review and meta-analysis显示文摘 | Anoop SV Shah Jeremy P Langrish Harish Nair David A McAllister Amanda L Hunter Ken Donaldson David E Newby Nicholas L Mills | 2013 | The Lancet2013，，： | 1 |
| 18 | Complexation of flavonoids with iron: structure and optical signatures显示文摘 | KEN JUN MENG SHENG LEKKA C E | 2008 | J Phys Chem2008，112，6： | 1 |
| 19 | Kinetoplastids: related protozoan pathogens, different diseases显示文摘 | Stuart Ken Brun Reto Croft Simon Fairlamb Alan Gürtler Ricardo E McKerrow Jim Reed Steve Tarleton Rick | 2008 | Journal of Clinical Investigation2008，，： | 1 |
| 20 | Ogunbiyi Twin-wire GMAW:Process Characteristics and Applications显示文摘 | Ken Michie Stephen Blackman T E B | 1999 | Welding Journal1999，78，5： | 1 |
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